Structurally Colored Thiol Chitosan Thin Films as a Platform for Aqueous Heavy Metal Ion Detection

Cathell, Matthew; Szewczyk, Janah C.; Bui, Frances A.; Weber, Carrie A.; Wolever, Jessica D.; J, Kang; Schauer, Caroline L.

doi:10.1021/bm700845z

Cited by 52 publications

(36 citation statements)

References 28 publications

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“…Other very recent approach involves the production and use of thiolated chitosan films for aqueous heavy metal ions detection, in particular for mercury [160]. The use of dendrimers combined with chitosan is currently under study for this kind of applications [161].…”

Section: Adsorption Of Metal Ionsmentioning

confidence: 99%

Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications

Alves

Mano

2008

International Journal of Biological Macromolecules

707

335

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Chitosan is a natural based polymer, obtained by alkaline deacetylation of chitin, which presents excellent biological properties such as biodegradability and immunological, antibacterial and wound-healing activity. Recently, there has been a growing interest in the chemical modification of chitosan in order to improve its solubility and widen its applications. The main chemical modifications of chitosan that have been proposed in the literature are reviewed in this paper. Moreover, these chemical modifications lead to a wide range of derivatives with a broad range of applications. Recent and relevant examples of the distinct applications, with particular emphasis on tissue engineering, drug delivery and environmental applications, are presented.

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Section: Adsorption Of Metal Ionsmentioning

confidence: 99%

Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications

Alves

Mano

2008

International Journal of Biological Macromolecules

707

335

View full text Add to dashboard Cite

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“…Coupled with the loss of amine signal indicates the formation of amide in SH-CHIT, with the appearance of amide I and amide II band signals at 1,657 and 1,562 cm −1 , respectively. It can be seen that the C-O-C stretch near 1,100 cm −1 remains essentially unchanged in SH-CHIT/ Au and CHIT/Au electrodes [18].…”

Section: Fourier Transformed Infrared Studiesmentioning

confidence: 94%

Thiol Modified Chitosan Self-Assembled Monolayer Platform for Nucleic Acid Biosensor

Mukherjee

Solanki

Sumana

et al. 2014

Appl Biochem Biotechnol

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A self-assembled monolayer (SAM) of thiol modified chitosan (SH-CHIT), with thioglycolic acid (TGA) as a modifier to bestow thiol groups, has been prepared onto gold (Au)-coated glass plates for fabrication of the nucleic acid biosensor. The chemical modification of CHIT via TGA has been evidenced by Fourier transform infrared spectroscopy (FT-IR) studies, and the biocompatibility studies reveal that CHIT retains its biocompatible nature after chemical modification. The electrochemical studies conducted onto SH-CHIT/Au electrode reveal that thiol modification in CHIT amino end enhances the electrochemical behavior indicating that it may be attributed to delocalization of electrons in CHIT skeleton that participates in the resonance process. The carboxyl group modified end of DNA probe has been immobilized onto SH-CHIT/Au electrode using N-ethyl-N'-(3-dimethylaminopropyl)carbodimide (EDC) and N-hydroxysuccinimide (NHS) chemistry for detection of complementary, one-base mismatch and non-complementary sequence using electrochemical and optical studies for Mycobacterium tuberculosis detection. It has been found that DNA-SH-CHIT/Au bioelectrode can specifically detect 0.01 μM of target DNA concentration with sensitivity of 1.69 × 10(-6) A μM(-1).

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“…Thin-film chitosan composites have been modified with polyallylamine, increasing the -NH 2 group content in thin film for qualitative detection of metal ions in wastewater (Schauer et al 2004). Cathell et al (2008) produced a colorimetric sensor containing thiol groups to chitosan film to enhance the selectivity for Hg(II) ions. Complexation of Hg(II) ions by thiolated groups changes the thickness, refractive index and color of the chitosan film.…”

Section: Chitosan-based Sensorsmentioning

confidence: 99%

Environmental Applications of Chitosan and Its Derivatives

Yong

Shrivastava

Srivastava

et al. 2014

Reviews of Environmental Contamination and Toxicology Volume 233

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Chitosan originates from the seafood processing industry and is one of the most abundant of bio-waste materials. Chitosan is a by-product of the alkaline deacetylation process of chitin. Chemically, chitosan is a polysaccharide that is soluble in acidic solution and precipitates at higher pHs. It has great potential for certain environmental applications, such as remediation of organic and inorganic contaminants, including toxic metals and dyes in soil, sediment and water, and development of contaminant sensors. Traditionally, seafood waste has been the primary source of chitin. More recently, alternative sources have emerged such as fungal mycelium, mushroom and krill wastes, and these new sources of chitin and chitosan may overcome seasonal supply limitations that have existed. The production of chitosan from the above-mentioned waste streams not only reduces waste volume, but alleviates pressure on landfills to which the waste would otherwise go. Chitosan production involves four major steps, viz., deproteination, demineralization, bleaching and deacetylation. These four processes require excessive usage of strong alkali at different stages, and drives chitosan's production cost up, potentially making the application of high-grade chitosan for commercial remediation untenable. Alternate chitosan processing techniques, such as microbial or enzymatic processes, may become more cost-effective due to lower energy consumption and waste generation. Chitosan has proved to be versatile for so many environmental applications, because it possesses certain key functional groups, including - OH and -NH2 . However, the efficacy of chitosan is diminished at low pH because of its increased solubility and instability. These deficiencies can be overcome by modifying chitosan's structure via crosslinking. Such modification not only enhances the structural stability of chitosan under low pH conditions, but also improves its physicochemical characteristics, such as porosity, hydraulic conductivity, permeability, surface area and sorption capacity. Crosslinked chitosan is an excellent sorbent for trace metals especially because of the high flexibility of its structural stability. Sorption of trace metals by chitosan is selective and independent of the size and hardness of metal ions, or the physical form of chitosan (e.g., film, powder and solution). Both -OH and -NH2 groups in chitosan provide vital binding sites for complexing metal cations. At low pH, -NH3 + groups attract and coagulate negatively charged contaminants such as metal oxyanions, humic acids and dye molecules. Grafting certain functional molecules into the chitin structure improves sorption capacity and selectivity for remediating specific metal ions. For example, introducing sulfur and nitrogen donor ligands to chitosan alters the sorption preference for metals. Low molecular weight chitosan derivatives have been used to remediate metal contaminated soil and sediments. They have also been applied in permeable reactive barriers to remediate metals in soil and groun...

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Structurally Colored Thiol Chitosan Thin Films as a Platform for Aqueous Heavy Metal Ion Detection

Cited by 52 publications

References 28 publications

Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications

Chitosan derivatives obtained by chemical modifications for biomedical and environmental applications

Thiol Modified Chitosan Self-Assembled Monolayer Platform for Nucleic Acid Biosensor

Environmental Applications of Chitosan and Its Derivatives

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