Structural transformations of arabinogalactan from the Siberian larch during mechanochemical processing and the biological properties of the products

Медведева, Е. Н.; Neverova, N. A.; Fedorova, T. E.; Babkin, V. A.; Meteleva, Elizaveta S.; Душкин, А. В.; Толстикова, Т. Г.; Хвостов, Михаил В.; Долгих, М. П.

doi:10.1134/s1068162010070101

Cited by 4 publications

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“…[ 28 ]. The quantitative monosaccharide composition and molecular weight of arabinogalactan vary not only depending on the type of larch, but also within the same species [ 31 ]. For galactan-containing polysaccharides, the most important characteristics are the size of the galactan core, the structure of the side chains, as well as the molecular weight and the ability to form intermolecular associates [ 27 , 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Arabinogalactan exhibits a wide range of biological properties: the immunobiological, hepatoprotective, antimutagenic, mitogenic, gastroprotective, and membranotropic activity; the probiotic, mycogenic, hypolipidemic, and immunomodulatory characteristics; the dispersing effect; etc. [ 27 , 29 , 30 , 31 ]. The macromolecule of arabinogalactan isolated from Siberian larch wood has a branched structure and a molecular weight of 15–20 kDa [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

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Modification of Arabinogalactan Isolated from Larix sibirica Ledeb. into Sulfated Derivatives with the Controlled Molecular Weights

et al. 2021

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The process of sulfation of arabinogalactan—a natural polysaccharide from Larix sibirica Ledeb.—with sulfamic acid in 1,4-dioxane using different activators has been studied for the first time. The dynamics of the molecular weight of sulfated arabinogalactan upon variation in the temperature and time of sulfation of arabinogalactan with sulfamic acid in 1,4-dioxane has been investigated. It has been found that, as the sulfation time increases from 10 to 90 min, the molecular weights of the reaction products grow due to the introduction of sulfate groups without significant destruction of the initial polymer and sulfation products. Sulfation at 95 °C for 20 min yields the products with a higher molecular weight than in the case of sulfation at 85 °C, which is related to an increase in the sulfation rate; however, during the further process occurring under these conditions, sulfation is accompanied by the destruction and the molecular weight of the sulfated polymer decreases. The numerical optimization of arabinogalactan sulfation process has been performed. It has been shown that the optimal parameters for obtaining a product with a high sulfur content are a sulfamic acid amount of 20 mmol per 1 g of arabinogalactan, a process temperature of 85 °C, and a process time of 2.5 h.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modification of Arabinogalactan Isolated from Larix sibirica Ledeb. into Sulfated Derivatives with the Controlled Molecular Weights

et al. 2021

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“…The X-ray phase study and thermal analysis prove the destruction of the crystal structure of MS and its dispersion within the AG matrix. The polysaccharide macromolecules are cleaved similarly to the mechanochemical activation of AG alone [49].…”

Section: Physicochemical and Biological Properties Of Arabinogalactanmentioning

confidence: 99%

“…As a result, the polysaccharide can change its biological activity, toxicity and pharmacological properties. HPLC and quantitative 13 C NMR spectroscopy has established [49] that mechanochemical treatment of AG isolated from Siberian larch wood changes its molecular weight distribution, monosaccharide composition and degree of branching due to partial destruction of the macromolecules and subsequent recombination of their fragments. The extent of these changes depends on the activation conditions.…”

Section: Physicochemical and Biological Properties Of Arabinogalactanmentioning

confidence: 99%

“…Meanwhile, single intravenous injection of the substance, in a dose of 3.5 mg/kg, slightly but statistically significantly decreases arterial pressure (by 6%) in normotensive rats without affecting electrocardiogram parameters and heart rate. Thus, mechanochemically activated AG is a promising drug carrier [49].…”

Section: Physicochemical and Biological Properties Of Arabinogalactanmentioning

confidence: 99%

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