Structural Re-arrangement and Peroxidase Activation of Cytochrome c by Anionic Analogues of Vitamin E, Tocopherol Succinate and Tocopherol Phosphate

Yanamala, Naveena; Kapralov, Alexandr A.; Djukić, Mirjana; Peterson, Jim; Mao, Gaowei; Klein‐Seetharaman, Judith; Stoyanovsky, Detcho A.; Štursa, Jan; Neužil, Jiřı́; Kagan, Valerian E.

doi:10.1074/jbc.m114.601377

Cited by 17 publications

(13 citation statements)

References 65 publications

(92 reference statements)

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“…33,34 In addition, a-TP and a-T influence cell proliferation, ROS production, and Akt phosphorylation in an antagonistic manner. 30,32,35 However, in this study, a-T and especially a-TP showed their effects and in turn inhibited apoptosis in the EPCs and influenced the migration of EPCs, capillary tube formation, and Akt phosphorylation. Besides, the two drugs seem not to work in an antagonistic manner as mentioned in the literature.…”

Section: Journal Of Vascular Surgerycontrasting

confidence: 48%

α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions

Zheng

Meng

et al. 2018

Journal of Vascular Surgery

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Section: Journal Of Vascular Surgerycontrasting

confidence: 48%

α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions

Zheng

Meng

et al. 2018

Journal of Vascular Surgery

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“…En concordancia con esta investigación, existe un estudio desarrollado por Al Deeb et al, donde se demostró que la vitamina E disminuye los defectos en el tubo neural en ratones que se les administró VPA. Esto se ex-plica ya que la vitamina E en el tubo neural actúa como potente antioxidante, disminuyendo el estrés oxidativo suprimiendo la vía ROS, de esta forma regula la liberación de Citocromo C en el citosol, actuando como factor protector para el desarrollo del sistema nervioso (Yanamala et al, 2014).…”

Section: Discussionunclassified

Efectos del Tratamiento con Vitamina E en el Tubo Neural y Médula Espinal en Embriones y Fetos de Ratones Mus musculus Expuestos al uso de Ácido Valproico

et al. 2016

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RESUMEN: El ácido valproico (VPA) es el principal anticonvulsivante utilizado contra la epilepsia durante la gestación. Sin embargo, en etapas iniciales del embarazo actúa como teratógeno y ocasiona malformaciones como fisura labio-palatina, alteraciones en el desarrollo genital y espina bífida, siendo esta última la más frecuente. Esto se produce debido al aumento de especies reactivas de oxígeno, pudiendo contrarrestarse administrando vitamina E. El objetivo fue determinar si la vitamina E disminuye el daño en tubo neural y médula espinal de embriones y fetos de ratonas expuestas a VPA. Se conformaron 8 grupos de animales. A los 8 días postfecundación se les administró a los grupos 1 y 5 suero fisiológico 0,3 mL; grupos 2 y 6 VPA 600 mg/Kg; grupos 3 y 7 VPA 600 mg/Kg y vitamina E 200 UI/Kg; grupos 4 y 8 vitamina E 200 UI/kg. A los 12 días post-fecundación, se sacrificaron los grupos 1, 2, 3 y 4, y a los 17 días los restantes grupos. Los embriones fueron procesados y teñidos con cresil violeta, observándose cortes histológicos a nivel cervical, torácico y lumbar. Los grupos tratados con vitamina E presentaron menor cantidad de neuroblastos y motoneuronas, pero de tamaño mayor en comparación al grupo tratado con VPA (p<0,05), siendo similares a los grupos controles. Al comparar el tubo neural y médula espinal en los distintos niveles (cervical, torácico y lumbar), no hubo diferencias estadísticamente significativas. La administración prenatal de vitamina E disminuye los defectos en tubo neural y médula espinal de embriones de 12 y 17 días de gestación sometidos a VPA.

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“…Apoptosis by αTS is also induced by targeting the ubiquinone-binding site of mitochondrial complex II (53). αTS and αTP recently were shown to bind to cytochrome c and activate its peroxidase activity by causing structural rearrangements (261). In NIH3T3 cells, αTS inhibits proliferation and induces apoptosis by decreasing oncogenic Ras protein levels and suppressing the levels of prosurvival protein kinase B (pPKB) and pErk1/2 as well as the expression of the transcriptional targets of oncogenic Ras such as c-Myc, cyclin D1, and E2F1 (52).…”

Section: Synthetic Vitamin E Analogues and Signal Transductionmentioning

confidence: 99%

Vitamin E: A Role in Signal Transduction

Zingg

2015

Annu. Rev. Nutr.

109

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Vitamin E modulates the activity of several signal transduction enzymes with consequent alterations of gene expression. At the molecular level, vitamin E may directly bind to these enzymes and compete with their substrates, or it may change their activity by redox regulation. The translocation of several of these enzymes to the plasma membrane is regulated by vitamin E, suggesting the modulation of protein-membrane interactions as a common mechanism for vitamin E action. Enzyme-membrane interactions can be affected by vitamin E by interference with binding to specific membrane lipids or by altering cellular structures such as membrane microdomains (lipid rafts). Moreover, competition by vitamin E for common binding sites within lipid transport proteins may alter the traffic of lipid mediators and thus affect their signaling and enzymatic conversion. In this review, the main effects of vitamin E on enzymes involved in signal transduction are summarized and possible molecular mechanisms leading to enzyme modulation are evaluated.

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Structural Re-arrangement and Peroxidase Activation of Cytochrome c by Anionic Analogues of Vitamin E, Tocopherol Succinate and Tocopherol Phosphate

Cited by 17 publications

References 65 publications

α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions

α-Tocopherol, especially α-tocopherol phosphate, exerts antiapoptotic and angiogenic effects on rat bone marrow-derived endothelial progenitor cells under high-glucose and hypoxia conditions

Efectos del Tratamiento con Vitamina E en el Tubo Neural y Médula Espinal en Embriones y Fetos de Ratones Mus musculus Expuestos al uso de Ácido Valproico

Vitamin E: A Role in Signal Transduction

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