Structural Organization of Dynamic Chromatin

Hizume, Kohji; Yoshimura, Shige H.; Kumeta, Masahiro

doi:10.1007/1-4020-5466-1_1

Cited by 3 publications

(2 citation statements)

References 147 publications

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“…There is also emerging evidence that other cytoplasmic IF proteins, such as keratins, localize to the nucleus [ 90 ]. Considering their conserved molecular structure and polymerization mechanisms, it is conceivable that not only vimentin but also various IF components and their accessory proteins can pass through the NPC.…”

Section: The Role Of Cytoskeletal Proteins In the Nucleusmentioning

confidence: 99%

Nucleocytoplasmic Shuttling of Cytoskeletal Proteins: Molecular Mechanism and Biological Significance

Kumeta

Yoshimura

Hejna

2012

International Journal of Cell Biology

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Various nuclear functional complexes contain cytoskeletal proteins as regulatory subunits; for example, nuclear actin participates in transcriptional complexes, and actin-related proteins are integral to chromatin remodeling complexes. Nuclear complexes such as these are involved in both basal and adaptive nuclear functions. In addition to nuclear import via classical nuclear transport pathways or passive diffusion, some large cytoskeletal proteins spontaneously migrate into the nucleus in a karyopherin-independent manner. The balance of nucleocytoplasmic distribution of such proteins can be altered by several factors, such as import versus export, or capture and release by complexes. The resulting accumulation or depletion of the nuclear populations thereby enhances or attenuates their nuclear functions. We propose that such molecular dynamics constitute a form of cytoskeleton-modulated regulation of nuclear functions which is mediated by the translocation of cytoskeletal components in and out of the nucleus.

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Section: The Role Of Cytoskeletal Proteins In the Nucleusmentioning

confidence: 99%

Nucleocytoplasmic Shuttling of Cytoskeletal Proteins: Molecular Mechanism and Biological Significance

Kumeta

Yoshimura

Hejna

2012

International Journal of Cell Biology

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“…Deformation is a fundamental cellular function, particularly when cells confront a mechanical ecto-stimulus. The actin cytoskeleton, composed of double chain F-actin and existing in the cytoplasm as a kind of complicated net structure (Li et al, 2003;Hizume et al, 2007), plays a significant role in these processes because it is a major determinant of cell shape. Under mechanical strain conditions, the cytoskeleton displays a dynamic state.…”

Section: Introductionmentioning

confidence: 99%

The mechanism of myoblast deformation in response to cyclic strain—A cytomechanical study

Zheng

Song

et al. 2008

Cell Biology International

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Mechanical strain is one of the important epigenetic factors that cause deformation and differentiation of skeletal muscles. This research was designed to investigate how myoblast deformation occurs after cyclic strain loading. Myoblasts were passaged three times and harvested; various cyclic strains (2.5kPa, 5kPa and 10kPa) were then loaded using a pulsatile mechanical system. The adaptive response of the myoblasts was observed at different time points (0.5h, 1h, 6h and 12h) post-loading. At the early stage of cyclic strain loading (<1h), almost no visible morphological changes were observed in the myoblasts. The actin cytoskeleton showed a disordered arrangement and a weak fluorescence expression; there was little expression of talin. At 6h and 12h post-loading, the myoblasts changed their orientation to parallel (in the 2.5kPa and 5kPa groups) or perpendicular (in the 10kPa group) to the direction of strain. Fluorescence expression of both the actin cytoskeleton and talin was significantly increased. The results suggest that cyclic strain has at least two ways to regulate adaptation of myoblasts: (1) by directly affecting actin cytoskeleton at an early stage post-loading to cause depolymerization; and (2) by later chemical signals transmitted from the extracellular side to intracellular side to initiate repolymerization.

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Chromosomal Distribution and Functional Interpretation of Epigenetic Histone Marks in Plants

Fuchs

Schubert

2011

Plant Cytogenetics

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Structural Organization of Dynamic Chromatin

Cited by 3 publications

References 147 publications

Nucleocytoplasmic Shuttling of Cytoskeletal Proteins: Molecular Mechanism and Biological Significance

Nucleocytoplasmic Shuttling of Cytoskeletal Proteins: Molecular Mechanism and Biological Significance

The mechanism of myoblast deformation in response to cyclic strain—A cytomechanical study

Chromosomal Distribution and Functional Interpretation of Epigenetic Histone Marks in Plants

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