Structural, optical, and magnetic properties of nanostructured Ag-substituted Co-Zn ferrites: insights on anticancer and antiproliferative activities

Abstract

Magnetic spinel ferrite nanoparticles possess high scientific attention for the researchers attributed to its broad area for biomedicine purposes, comprising cancer magnetic hyperthermia and targeted drug delivery. Herein, we report the ultrasound irritation assisted the sol-gel method for the spinel Zn 0.5 Co 0.5x Ag 2x Fe 2 O 4 (x = 0.00, 0.10, 0.20, and 0.30) nanoparticles (NPs) synthesis. The Rietveld refinement patterns revealed the successful synthesis of the cubic structure Zn 0.5 Co 0.5-x Ag 2x Fe 2 O 4 and the crystallite size ranged from 14.1 nm to 18.4 nm. Also, the optical band gap decreased from 2.39 eV for Co-Zn ferrite to 2.20 eV for Zn 0.5 Co 0.2 Ag 0.6 Fe 2 O 4 sample. Electron paramagnetic resonance spectroscopy was used to study ferromagnetic resonance characteristics of the Zn 0.5 Co 0.5-x Ag 2x Fe 2 O 4 samples. The resonance field was increased from 2512.2 Gauss for Co-Zn ferrite sample to 2834.8 Gauss for Zn 0.5 Co 0.2 Ag 0.6 Fe 2 O 4 sample, while the line width decreased from 2401.3 to 1990.1 Gauss. Also, the saturation was reduced from 45.68 emu.g -1 for the pristine Zn 0.5 Co 0.5 Fe 2 O 4 sample to 22.20 emu.g -1 for Zn 0.5 Co 0.2 Ag 0.6 Fe 2 O 4 sample. Furthermore, cytotoxicity of Zn 0.5-Co 0.2 Ag 0.6 Fe 2 O 4 NPs against human breast cancer MCF-7, HepG2 liver cancer, and LoVo colorectal cancer cells was examined. The cytotoxicity of Zn 0.5 Co 0.2-Ag 0.6 Fe 2 O 4 on the previous cancer cell lines resulted in inhibition of cell growth estimated by MTT assay.

Engineered Polyethylene Glycol-Coated Zinc Ferrite Nanoparticles as a Novel Magnetic Resonance Imaging Contrast Agent

“…Raised ROS levels can induce mitochondrial malfunction, DNA damage, and protein damage in the cells, leading to the suppression of cell growth and eventually cell death . All these data clearly revealed that the cytotoxicity of Zn ferrite NPs was dependent on concentration and exposure period, as has been reported in earlier investigations. − The Zn ferrite NPs were established to be expressively more cytotoxic to HSF-1184 cells as compared to PEG@Zn ferrite NPs, which might be linked with the inherent anticancer characteristic of Zn ferrite NPs . In addition, cells treated with PEG@Zn ferrite NPs acquired a considerable viability of approximately 100% at 600 μg/mL concentration and 80% at 900 μg/mL concentration.…”

“…80−82 The Zn ferrite NPs were established to be expressively more cytotoxic to HSF-1184 cells as compared to PEG@ Zn ferrite NPs, which might be linked with the inherent anticancer characteristic of Zn ferrite NPs. 83 In addition, cells treated with PEG@Zn ferrite NPs acquired a considerable viability of approximately 100% at 600 μg/mL concentration and 80% at 900 μg/mL concentration. These results suggest that the biocompatibility of Zn ferrite NPs was significantly enhanced when coated with PEG, as reported elsewhere.…”

Gamma radiation assisted green synthesis of hesperidin-reduced graphene oxide nanocomposite targeted JNK/SMAD4/MMP2 signaling pathway

“…Each sample and control were analyzed in triplicate in three separate tests. The percentage growth (%) of viable cells that were subjected to various treatments was determined using the following calculation method [33][34][35][36][37] :…”