Structural nanotechnology: three-dimensional cryo-EM and its use in the development of nanoplatforms for<i>in vitro</i>catalysis

Ruiter, Mark V. de; Klem, Robin; Luque, Daniel; Cornelissen, Jeroen J. L. M.; Castón, José R.

doi:10.1039/c8nr09204d

Cited by 15 publications

(10 citation statements)

References 194 publications

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“…The infusion technique aims to disperse a load of interest onto preformed viral particles, while the method for caging triggers particulate forming from around content load. It also aims to encourage plant viral particles' packaging with external loads [ 59 , 60 ]. The genetic engineering of TMV-Lys at position 158 has been utilised as a scaffold for the bioconjugation of sulfo-Cyanine5 fluorescent tag for fluorescent imaging that laid the foundation for developing rod-shaped viruses as drug carriers scaffolds [ 61 ].…”

Section: Production Of Virions and Virus-like Particlesmentioning

confidence: 99%

The Viral Capsid As Novel Nanomaterials for Drug Delivery

Aljabali

Hassan²,

Pabari

et al. 2021

Future Sci. OA

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The purpose of this review is to highlight recent scientific developments and provide an overview of virus self-assembly and viral particle dynamics. Viruses are organized supramolecular structures with distinct yet related features and functions. Plant viruses are extensively used in biotechnology, and virus-like particulate matter is generated by genetic modification. Both provide a material-based means for selective distribution and delivery of drug molecules. Through surface engineering of their capsids, virus-derived nanomaterials facilitate various potential applications for selective drug delivery. Viruses have significant implications in chemotherapy, gene transfer, vaccine production, immunotherapy and molecular imaging.

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Section: Production Of Virions and Virus-like Particlesmentioning

confidence: 99%

The Viral Capsid As Novel Nanomaterials for Drug Delivery

Aljabali

Hassan²,

Pabari

et al. 2021

Future Sci. OA

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“…No DNA viruses have been isolated from Fusarium species. Additionally, purified virions of Fusarium mycoviruses can be obtained in large quantities and of high quality and can serve as good material for structural analysis, which will promote a better understanding of mycovirus assembly, function, evolution, and its uses in nanotechnological applications (Ghabrial et al, 2015; De Ruiter et al, 2019).…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Mycoviruses in Fusarium Species: An Update

Bhattacharjee

Wang

et al. 2019

Front. Cell. Infect. Microbiol.

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Fusarium is an important genus of plant pathogenic fungi, and is widely distributed in soil and associated with plants worldwide. The diversity of mycoviruses in Fusarium is increasing continuously due to the development and extensive use of state-of-the-art RNA deep sequencing techniques. To date, fully-sequenced mycoviruses have been reported in 13 Fusarium species: Fusarium asiaticum, F. boothii, F. circinatum, F. coeruleum, F. globosum, F. graminearum, F. incarnatum, F. langsethiae, F. oxysporum, F. poae, F. pseudograminearum, F. solani , and F. virguliforme . Most Fusarium mycoviruses establish latent infections, but some mycoviruses such as Fusarium graminearum virus 1 (FgV1), Fusarium graminearum virus-ch9 (FgV-ch9), Fusarium graminearum hypovirus 2 (FgHV2), and Fusarium oxysporum f. sp. dianthi mycovirus 1 (FodV1) cause hypovirulence. Rapid advances in various omics technologies used to elucidate genes or biological processes can facilitate an improved understanding of mycovirus-host interactions. The review aims to illuminate the recent advances in studies of mycoviruses in Fusarium , including those related to diversity, molecular mechanisms of virus-host interaction. We also discuss the induction and suppression of RNA silencing including the role of RNAi components as an antiviral defense response.

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“…Improved understanding of the molecular structures and underlying mechanisms evolved to optimize biochemical reactions has stimulated molecular engineers to modify bacterial protein compartments [5,10] and other synthetic and natural protein cages for biotechnological applications [19]; these include lumazine synthase [20], ferritins [21], viruslike particles [22], and vault ribonucleoproteins [23]. Although protein cage engineering is in its infancy, we are already witnessing the development of promising applications in fields as diverse as vaccine therapy [24], drug delivery [25], medical imaging [26], photodynamic treatments for cancer [27], and pest control [28].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnological Applications Based on Bacterial Encapsulins

et al. 2021

Self Cite

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Encapsulins are proteinaceous nanocontainers, constructed by a single species of shell protein that self-assemble into 20–40 nm icosahedral particles. Encapsulins are structurally similar to the capsids of viruses of the HK97-like lineage, to which they are evolutionarily related. Nearly all these nanocontainers encase a single oligomeric protein that defines the physiological role of the complex, although a few encapsulate several activities within a single particle. Encapsulins are abundant in bacteria and archaea, in which they participate in regulation of oxidative stress, detoxification, and homeostasis of key chemical elements. These nanocontainers are physically robust, contain numerous pores that permit metabolite flux through the shell, and are very tolerant of genetic manipulation. There are natural mechanisms for efficient functionalization of the outer and inner shell surfaces, and for the in vivo and in vitro internalization of heterologous proteins. These characteristics render encapsulin an excellent platform for the development of biotechnological applications. Here we provide an overview of current knowledge of encapsulin systems, summarize the remarkable toolbox developed by researchers in this field, and discuss recent advances in the biomedical and bioengineering applications of encapsulins.

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Structural nanotechnology: three-dimensional cryo-EM and its use in the development of nanoplatforms forin vitrocatalysis

Abstract: Three-dimensional cryo-EM analysis of protein-based nanoreactors to improvein vitrocatalysis.

Cited by 15 publications

References 194 publications

The Viral Capsid As Novel Nanomaterials for Drug Delivery

The Viral Capsid As Novel Nanomaterials for Drug Delivery

Mycoviruses in Fusarium Species: An Update

Nanotechnological Applications Based on Bacterial Encapsulins

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