Structural Interpretation of the In Vitro Reactivity of SiO&lt;sub&gt;2&lt;/sub&gt;-MgO-Na&lt;sub&gt;2&lt;/sub&gt;O Glasses

Agathopoulos, Simeon; Ferro, Marta C.; Xu, Jia; Oliveira, José M.; Marques, Paula A.A.P.; Correia, Raquel; Fernandes, Maria Helena

doi:10.4028/www.scientific.net/kem.240-242.217

Cited by 10 publications

(4 citation statements)

References 11 publications

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“…), Q 0 ‐rich glasses show accelerated early stages of mineralization. Further investigations have demonstrated that in a SiO 2 –MgO–Na 2 O system in the presence of 55 mol% SiO 2 , with increasing MgO/Na 2 O molar ratios from 1/8 to 8/1, the Q 2 /Q 3 ratio decreases and the glass surface changes from highly bioactive to an inert surface in SBF. Comparing these results with the SiO 2 –P 2 O 5 –CaO–MgO system, the composition dependence of the role of MgO in the glass structure can be assessed, revealing that in the SiO 2 –P 2 O 5 –CaO–MgO system MgO acts as network modifier, disturbs the glass structure, and increases in vitro bioactivity whereas in the SiO 2 –MgO–Na 2 O system this role is played by Na 2 O.…”

Section: Mg‐containing Bioactive Glassesmentioning

confidence: 98%

Magnesium‐Containing Bioactive Glasses for Biomedical Applications

Diba

Tapia

Boccaccını

et al. 2012

Int J of Appl Glass Sci

182

105

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The importance of Mg in the human body, its key role in bone tissue development, in addition to its application to improve and modify physical, thermal, and mechanical properties of bioactive silicate glasses, make Mg a very interesting element as a component of bioactive glasses for medical applications. Although Mg is a typical element in the composition of numerous developed bioactive glasses, the analysis of the literature reveals that further research is required to gain comprehensive understanding about the effects of MgO on bioactive glass structure and properties. This article presents a comprehensive overview of the field of Mg‐containing bioactive glasses discussing available compositions and summarizing existing knowledge on effects of MgO on glass properties. The biomedical applications of several developed glasses are discussed highlighting the distinct effects of Mg in relevant areas, such as bioactivity and cell response, and focusing on the most common applications for these glasses, such as bone cements, bioactive coatings, and scaffolds for bone tissue engineering. The effect of Mg on bone development is discussed and avenues for future research in the field are proposed, emphasizing the need to investigate unstudied properties of (already developed) Mg‐containing glass compositions, such as angiogenesis‐stimulating action and the effect on osteoclast functions, to develop new Mg‐containing bioactive glasses as well as to make products of different shape designs such as nanoparticles, fibers, and complex porous structures.

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Section: Mg‐containing Bioactive Glassesmentioning

confidence: 98%

Magnesium‐Containing Bioactive Glasses for Biomedical Applications

Diba

Tapia

Boccaccını

et al. 2012

Int J of Appl Glass Sci

182

105

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“…To assess the structural composition of silicate‐chlorinated BG, Raman spectroscopy was employed (Figure 1A). It is noteworthy that the glass structure was constituted by Q 2 silica structural units, 28 as evidenced by the prominent band positioned at 960 cm −1 29 . Additionally, a minor peak is discernible around 1050 cm −1 , which can be related to the PO stretching modes 30 .…”

Section: Resultsmentioning

confidence: 91%

“…It is noteworthy that the glass structure was constituted by Q 2 silica structural units, 28 as evidenced by the prominent band positioned at 960 cm À1 . 29 Additionally, a minor peak is discernible around 1050 cm À1 , which can be related to the P O stretching modes. 30 For assessment of the functional groups, FTIR spectroscopy was employed (Figure 1B).…”

Section: Chemical Physical and Morphological Characterization Of Bg P...mentioning

confidence: 97%

Biodegradable electrospun poly(L‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering

de Souza,

Cardoso,

de Toledo

et al. 2024

J Biomed Mater Res

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The field of tissue engineering has witnessed significant advancements in recent years, driven by the pursuit of innovative solutions to address the challenges of bone regeneration. In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L‐lactide‐co‐ε‐caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate‐chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone‐derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently enhancing hydrophilicity. Thermal gravimetric analysis confirmed the efficient incorporation of BG, with the scaffolds demonstrating thermal stability up to 250°C. Mechanical testing revealed enhanced tensile strength and Young's modulus in the presence of BG; however, the elongation at break decreased. Cell viability assays demonstrated improved cytocompatibility, especially in the PLCL/PEG+BG group. Alizarin red staining indicated enhanced osteoinductive potential, and fluorescence analysis confirmed increased cell adhesion in the PLCL/PEG+BG group. Our findings suggest that the PLCL/PEG/BG composite scaffold holds promise as an advanced biomaterial for bone tissue engineering.

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“…Furthermore, the use of appropriate characterization techniques is another important step in this process. Thus, information provided by conventional techniques based on photon–matter interaction, such as Fourier transform infrared (FTIR) and Raman spectroscopies and X‐ray diffraction 25–55 can be complemented by techniques based on magnetic field–matter interaction (nuclear magnetic resonance [NMR]) to examine the glass structure at the microscale level 56–69 . In this work, the silicate network is described by the nomenclature, where denotes the tetrahedral structural unit and n the number of bridging oxygen per tetrahedron.…”

Section: Introductionmentioning

confidence: 99%

Nanostructural Transitions in Bioactive Sol-Gel Silicate Glasses

Aguiar

Serra

González

2011

International Journal of Applied Ceramic Technology

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A study of the short‐range organization of bioactive SiO2–P2O5–CaO sol–gel glasses using high‐resolution transmission electron microscopy, Fourier transform infrared and magic angle spinning—nuclear magnetic resonance spectroscopies are reported. These combined techniques were used to investigate the rearrangement of the glass matrix and to clarify the role of phosphorus and calcium during the heat‐treatment stage of the sol–gel process. The study shows how the incorporation of calcium into the glass structure promotes the appearence of P–O–NBO groups and that the glass nanostructure is induced to form Ca‐rich orthophosphate units.

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Structural Interpretation of the In Vitro Reactivity of SiO<sub>2</sub>-MgO-Na<sub>2</sub>O Glasses

Cited by 10 publications

References 11 publications

Magnesium‐Containing Bioactive Glasses for Biomedical Applications

Magnesium‐Containing Bioactive Glasses for Biomedical Applications

Biodegradable electrospun poly(L‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/bioactive glass composite scaffold for bone tissue engineering

Nanostructural Transitions in Bioactive Sol-Gel Silicate Glasses

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