Structural impact of graft and block copolymers based on poly(N-vinylpyrrolidone) and poly(2-dimethylaminoethyl methacrylate) in gene delivery

Xiang, Zheng; Zhang, Tingbin; Song, Xiaoyan; Zhang, Ling; Zhang, Chunqiu; Jin, Shubin; Xing, Jinfeng; Liang, Xing‐Jie

doi:10.1039/c4tb01956c

Cited by 22 publications

(15 citation statements)

References 53 publications

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“…However, in this study, the REDV-PPP2/pZNF580 complex group showed lower transfection than the REDV-PPP1/pZNF580 complex group. 53 Although the zeta potential of complexes usually facilitates cellular uptake, our results have demonstrated that the REDV amount in NP/pZNF580 complexes also benefits to cellular uptake.…”

Section: Discussionmentioning

confidence: 56%

REDV–polyethyleneimine complexes for selectively enhancing gene delivery in endothelial cells

Yang

et al. 2016

J. Mater. Chem. B

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Section: Discussionmentioning

confidence: 56%

REDV–polyethyleneimine complexes for selectively enhancing gene delivery in endothelial cells

Yang

et al. 2016

J. Mater. Chem. B

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“…Up to now, PVP has been used in the pharmaceutical and biomedical fields to develop different drug delivery systems, such as oral, topical, transdermal, and ocular administration. Besides, PVP is also useful in the delivery of genes [8][9][10][11][12] or can be coupled with metal particles for regenerative medicine [13][14][15] and targeted-delivery [16,17]. Therefore, PVP results to also be a very versatile polymer.…”

Section: Introductionmentioning

confidence: 99%

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

2020

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Polyvinylpyrrolidone (PVP) is a hydrophilic polymer widely employed as a carrier in the pharmaceutical, biomedical, and nutraceutical fields. Up to now, several PVP-based systems have been developed to deliver different active principles, of both natural and synthetic origin. Various formulations and morphologies have been proposed using PVP, including microparticles and nanoparticles, fibers, hydrogels, tablets, and films. Its versatility and peculiar properties make PVP one of the most suitable and promising polymers for the development of new pharmaceutical forms. This review highlights the role of PVP in drug delivery, focusing on the different morphologies proposed for different polymer/active compound formulations. It also provides detailed information on active principles and used technologies, optimized process parameters, advantages, disadvantages, and final applications.

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“…As cationic components for polyplex formation, poly(ethylene imine), poly( N , N ‐dimethylaminoethyl) structures, poly( l ‐lysine) and several other structures that bear primary, secondary, tertiary or quarternized amines have been used frequently. [ 21–30 ] Incorporation of poly(ethylene glycol), poly(2‐oxazoline), or polysarcosine increases the solubility of the polyplex and further decreases interaction with blood components. [ 12,31–39 ]…”

Section: Introductionmentioning

confidence: 99%

RAFT Synthesis of Reactive Multifunctional Triblock‐Copolymers for Polyplex Formation

Ritt

Ayaou

Zentel

2021

Macro Chemistry & Physics

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Reversible addition–fragmentation chain transfer polymerization with a low‐temperature initiator can be used to synthesize multifunctional block copolymers for polyplex formation. Utilizing three methacrylate monomers (triethylene glycol methyl ether methacrylate (MEO3MA), pyridyldisulfideethyl methacrylate (PDSM), N,N‐dimethylethylenediamine methacrylate (DMAEMA)) and an azide bearing chain transfer agent for polymerization, the resulting triblock‐copolymers possess two orthogonally reactive functionalities (a block with reactive disulfide side chains and an azide end‐group) and two additional functional blocks for i) solubilization and ii) polyplex formation. Thereby, the MEO3MA block provides solubility in aqueous media and the DMAEMA block, having a tertiary amine in the side chain, allows polyplex formation with polyanionic biomacromolecules like DNA or RNA. Due to the reactive disulfide block the polyplexes can be (reversibly) crosslinked with dithiols. Because of the manifold of possibilities to modify the pDNApolyplexes, this polymers system is an interesting candidate for active‐targeting and codelivery approaches.

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Structural impact of graft and block copolymers based on poly(N-vinylpyrrolidone) and poly(2-dimethylaminoethyl methacrylate) in gene delivery

Abstract: The characteristics of graft and block copolymers based on PVP and PDMAEMA in pDNA compaction, cytotoxicity, transfection efficiency, internalization and intracellular distribution were systematically investigated.

Cited by 22 publications

References 53 publications

REDV–polyethyleneimine complexes for selectively enhancing gene delivery in endothelial cells

REDV–polyethyleneimine complexes for selectively enhancing gene delivery in endothelial cells

The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

RAFT Synthesis of Reactive Multifunctional Triblock‐Copolymers for Polyplex Formation

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