Structural-Functional Peculiarities of the Urinary Bladder in Postnatal Ontogenesis

Abstract

It is known about the high incidence of the urinary bladder lesions in the structure of urological pathology regardless of age; however, according to the analysis of world literature sources, data on postnatal ontogenetic transformations of its wall constituents are poorly studied. Therefore, the purpose of our work was to study the morphofunctional peculiarities of the urinary bladder during sexual formation and puberty in parallel with research of pro-and antioxidant systems, as these processes are interrelated and interdependent. In compliance with bioethical principles, in the experiment on 20 immature and 20 mature white outbred male rats using a complex research methods (injection, histological, immune-histochemical, electronic-microscopic and biochemical) the structural changes in the wall of the urinary bladder and pro-and antioxidant systems in stages of postnatal ontogenesis were studied. Vascular transformations in investigated age periods occur in parallel with the transformations of cellular and non-cellular elements of the urinary bladder wall, ensuring adequacy of tissue homeostasis in ontogenesis. All this is associated with the processes of peroxidation and antioxidant systems operation, indicating their interrelationship and interdependence and strict control of the whole hierarchical system of regulation. Taking into account the peculiarities of the structural elements of the urinary bladder wall at these stages of postnatal ontogenesis, clarification of the dynamics in other age groups and under the influence of various factors is promising.