Structural elucidation of silica present in kidney stones coming from Burkina Faso

Dessombz, Arnaud; Coulibaly, G.; Kirakoya, Brahima; Ouedraogo, Richard; Lengani, A.; Rouzière, Stéphan; Weil, Raphaël; Picaut, Lise; Bonhomme, Christian; Babonneau, Florence; Bazin, Dominique; Daudon, Michel

doi:10.1016/j.crci.2016.06.012

Cited by 15 publications

(16 citation statements)

References 56 publications

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“…In hospitals, optical microscopy, FTIR, FTIR microscopy, SEM (Scanning Electron Microscopy) and X-ray diffraction are used in routine mode. Curiously, solid state NMR has been used very rarely in the context of KS (and other pathological calcifications) apart from sparse 13 C and 31 P studies (Bak et al, 2000;Jayalakshmi et al, 2009;Reid et al, 2011;Reid et al, 2013;Li et al, 2016;Dessombz et al, 2016), unlike other human hard tissues such as bones and teeth. This is probably due to the fact that solid state NMR instruments are not widely available in hospital settings.…”

Section: Introductionmentioning

confidence: 99%

A novel multinuclear solid state NMR approach for the characterization of kidney stones

Leroy¹,

Bonhomme-Coury²,

Gervais³

et al. 2021

Preprint

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Abstract. The spectroscopic study of pathological calcifications (including kidney stones) is extremely rich and helps to improve the understanding of the physical and chemical processes associated with their formation. While FTIR imaging and optical/electron microscopies are routine techniques in hospitals, there has been a dearth of solid state NMR studies introduced into this area of medical research, probably due to the scarcity of this analytical technique in hospital facilities. This work introduces effective multinuclear and multi-dimensional solid state NMR methodologies to study the complex chemical and structural properties characterising kidney stone composition. As a basis for comparison three hydrates (n = 1, 2 and 3) of calcium oxalate are examined along with nine representative kidney stones. The multinuclear MAS NMR approach adopted investigates the 1H, 13C, 31P and 43Ca nuclei, with the 1H and 13C MAS NMR data able to be readily deconvoluted into the constituent elements associated with the different oxalates and organics present. For the first time, the full interpretation of highly resolved 1H NMR spectra is presented for the three hydrates, based on structure and local dynamics. The corresponding 31P MAS NMR data indicates the presence of low-level inorganic phosphate species, however the complexity of these data make the precise identification of the phases difficult to assign. This work provides physicians, urologists and nephrologists with additional avenues of spectroscopic investigation to interrogate this complex medical dilemma that requires real multi technique approaches to generate effective outcomes.

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Section: Introductionmentioning

confidence: 99%

A novel multinuclear solid state NMR approach for the characterization of kidney stones

Leroy¹,

Bonhomme-Coury²,

Gervais³

et al. 2021

Preprint

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“…Very few results are available in literature which reports the analysis of urinary stones particularly using XRF techniques . Sometimes, the literature often refers to an entire group of urinary stones without any classification or simply divides them into a few groups.…”

Section: Resultsmentioning

confidence: 99%

“…Morzon et al have applied XRF analysis using synchrotron radiation (SRXRF) for the determination of micro elemental and mineral composition of some kidney stones. Dessombz et al used XRF to show the presence of Al (55 ppm) and Si to indicate the presence of aluminosilicate phases in kidney stones. In our study, we have detected Al with low concentration up to 36 ppm which is supported by the results by Dessombz et al …”

Section: Resultsmentioning

confidence: 99%

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Spectroscopic investigations on kidney stones using Fourier transform infrared and X-ray fluorescence spectrometry

et al. 2017

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Kidney stone is the most painful and prevalent urological disorder of the urinary system throughout the world. Thus, analysis of kidney stones is an integral part in the evaluation of patents having stone disease. Spectroscopic investigations of stones provide an idea about the pathogenesis of stones for its better cure and treatment. Hence, the present work targets multispectroscopic investigations on kidney stones using Fourier transform infrared (FTIR) and wave dispersive X-ray fluorescence (WD-XRF) spectroscopy which are the most useful analytical methods for the purpose of bio-medical diagnostics. In the present study, FTIR spectral method is used to investigate the chemical composition and classification of kidney stones. The multicomponents of kidney stones such as calcium oxalate, hydroxyl apatite, phosphates, carbonates, and struvite were investigated and studied. Qualitative and quantitative determination of major and trace elements present in the kidney stones was performed employing WD-XRF spectroscopy. The wide range of elements determined in the kidney stones were calcium (Ca), magnesium (Mg), phosphorous (P), sodium (Na), potassium (K), chlorine (Cl), sulfur (S), silicon (Si), iodine (I), titanium (Ti), iron (Fe), ruthenium (Ru), zinc (Zn), aluminum (Al), strontium (Sr), nickel (Ni), copper (Cu), and bromine (Br). For the first time, ruthenium was detected in kidney stone samples employing WD-XRF in very low concentration. Our results revealed that the presence and relative concentrations of trace elements in different kinds of stones are different and depend on the stone types. From the experiments carried out on kidney stones for trace elemental detection, it was found that WD-XRF is a robust analytical tool that can be useful for the diagnosis of urological disorders. We have also compared our findings with the results reported using XRF technique. The results obtained in the present paper show interesting prospects for FTIR and WD-XRF spectrometry in nephrolithiasis. Copyright

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“…87 Finally, some silica objects have been identified in the centre of granuloma present in skin and also in kidney stones. [88][89][90][91] In a recent publication, following a demand from a dermatologist, we analysed abnormal deposits present on the surface of hairs. We pointed out the presence of titanium dioxide.…”

Section: A Huge Chemical Diversitymentioning

confidence: 99%

Physicochemistry in medicine: some selected examples

Bazin

Daudon

2019

J. Spectral Imaging

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Research on pathological calcifications constitutes an exciting topic at the interface between physics, chemistry and medicine. The relationship between their physicochemical characteristics and the pathology responsible for their formation offers a unique opportunity to perform a significant medical diagnosis, to assess the interaction between drugs and these biological entities as well as to develop new drugs. Regarding synchrotron radiation, the emergence of microbeam allows the clinician to perform an early diagnosis. Indeed, we will start this review with a clinical case where Fourier transform infrared spectroscopy using synchrotron radiation as a probe allowed the clinician to save the kidney function of a patient. Following this example, we will see that investigations on pathological calcifications constitute an elegant way to gather major information on different public health problems such type 2 diabetes as well as on rare diseases. To attain this goal, this mini-review dedicated to structural and chemical investigations and based on selected and recent data collected through techniques using third generation synchrotron radiation as a probe is proposed to the reader.

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Structural elucidation of silica present in kidney stones coming from Burkina Faso

Cited by 15 publications

References 56 publications

A novel multinuclear solid state NMR approach for the characterization of kidney stones

A novel multinuclear solid state NMR approach for the characterization of kidney stones

Spectroscopic investigations on kidney stones using Fourier transform infrared and X-ray fluorescence spectrometry

Physicochemistry in medicine: some selected examples

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