Structural dynamism of chiral sodium peraza-macrocycle complexes derived from cyclic peptoids

Abstract

A variety of cyclen and hexacyclen derivatives decorated with (S)-1-phenylethy side chains or (S)-pyrrolidine units have been prepared via reductive approach from the corresponding cyclic peptoids containing N-(S)-(1-phenylethyl)glycine and L-proline...

1,2,3‐Triazole‐Containing Azamacrocycles from Chiral Triazolopeptoids: Synthesis and Solid‐State Studies

“…[5] Recently we reported an efficient reductive route from cyclic peptoids, a valuable class of peptidomimetics, [6][7][8][9] to differently decorated peraza-macrocycles. [10] This synthetic strategy yields an ample variety of homo-and hetero-substituted azacoronands [10,11] and does not require low-yield regioselective post synthetic modifications or intricate protecting group manipulations, as in the classic synthetic approaches. [10] In our ongoing research on macrocyclic peptoids we recently reported a new class of "extended" peptoids (1-3).…”

“…11 B-NMR (192.5 MHz, CDCl 3 ) δ: À 20.1 (bs) 13. C NMR (150 MHz, CDCl 3 ) δ: 145.1 (x 2), 137.8 (x 2), 129.3 (x 4), 128.9 (x 4), 128.0 (x 2), 124.1 (x2), 59.2 (x2), 53.5 (x2), 50.1 (x2), 45.8 (x2).…”