1,2,3‐Triazole‐Containing Azamacrocycles from Chiral Triazolopeptoids: Synthesis and Solid‐State Studies
Alicja M. Araszczuk,
Giovanni Pierri,
Rosaria Schettini
et al.
Abstract:Two new chiral 1,2,3‐triazole‐containing macrocyclic oligoamides (i.e.: triazolopeptoid 4 and 5) were obtained through solid‐phase synthesis of linear precursors followed by high dilution macrocyclization reaction. Theoretical (DFT) and spectroscopic (NMR) studies revealed the intricate interplay between the Na‐chiral side chains and their conformational attitudes. BH3‐mediated reduction of the tertiary amide groups of known 1‐3 and newly synthesized 4 gave novel azamacrocycles 6‐9. Detection of borane complex… Show more
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