Structural diversity of organochlorine compounds in groundwater affected by an industrial point source

Toxicity, dioxin-like activities, and endocrine effects of DDT metabolites—DDA, DDMU, DDMS, and DDCN

“…Moreover, our data clearly indicate that both cytotoxicity and estrogenicity of the DDT metabolites decline along the DDT catabolism pathway. This coincides with an increasing level of polarity of the DDT metabolites and therefore, to an increase in their water solubility (DDT 0.003-0.04 mg/l; DDA 11-390 mg/l; Frische et al 2010). On the one hand, the more polar the DDT metabolites are the higher are their water solubility (higher doses), bioaccessibility, and the metabolism and excretion rates in inner organisms.…”

“…Although the polar DDT metabolites showed a relatively lower ecotoxicological potencies when compared to DDT, we still suggest to include them in the risk assessment if the concentrations have reached levels beyond 100 times greater than those of DDT (as shown, e.g., for the Teltow Canal). Regarding the water phase, the more polar metabolites, in particular DDA, represents the dominant DDX species in pore water, riverine water, and groundwater (Heberer and Dünnbier 1999;Heim et al 2005;Frische et al 2010). Hence, an urgent need for a comprehensive ecotoxicological characterisation of all DDT metabolites in the aquatic environment becomes more obvious.…”

Organic Pollution of Water and Human Health

“…Persistent organic pollution is a threat to human life to different degrees which have not been yet fully examined [26][27][28][29][30]. Therefore in order to protect human health it is necessary to develop chemical trace analysis -eco analysis in complex monitoring and protection of environment we live in.…”

“…It was produced industrially until the late 1980s when it was banned because of the high toxicity. However, it can still be detected in the environment, which poses a threat to human health because of its suspected carcinogenicity [17,26].…”

“…Persistent organic pollutants (POPs) poses a threat to human health and environment. They cause especially neurotoxicity and endocrine disrupting, which are not fully examined [26][27][28][29].…”