Structural Differences of Fast and Slow Fibers in Human Extraocular Muscle

Brandt, David E.; Leeson, C. Roland

doi:10.1016/0002-9394(66)91327-4

Cited by 26 publications

(5 citation statements)

References 13 publications

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“…Similar attempts for human EOM have failed in part due to the limited number of previous ultrastructural studies. Based upon our matching of fibers in adjacent histochemical and thin sections, the coarse and granular fibers and the fine fibers most likely correspond to the Fibrillenstruktur and Felderstruckter fibers previously described (Brandt and Leeson, 1966;Dietert, 1965;Mukuno, 1966). Although the cryostat retrieval technique is a powerful means of correlating histochemical and fine structural characteristics for the same fiber, it is too time consuming to be of practical use in most studies of muscle.…”

Section: Global Zone Fibersmentioning

confidence: 98%

“…The fine structural characteristics of normal and diseased human limb muscle are well defined (Neville, 1979). Similar attempts to correlate the fine structural changes in diseased EOM (Berard-Badier, et al, 1978;Kuwabara and Lessell, 1976;Culebras and Merk, 1975), especially those relating to the size and distribution of mitochondria (Bastiaensen, et al, 1977;Margolio et al, 1977), to normal EOM have been hindered by the lack of adequate studies on normal fine structure (Brandt and Leeson, 1966;Dietert, 1965;Mukuno, 1966).…”

mentioning

confidence: 99%

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Mitochondrial morphometrics of histochemically identified human extraocular muscle fibers

1986

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Three fiber types--coarse, granular, and fine--were readily identified in histochemical cryostat sections of human extraocular muscle (EOM). The cryostat retrieval method was utilized to identify these three fiber types in serial electron microscopic thin sections. Using morphometric techniques, five mitochondrial variables (mitochondrial volume fraction, mitochondrial profile size, mitochondrial profile density, and clusters of two or of three or more mitochondrial profiles) were determined for a total of 162 histochemically identified fibers from two regions (orbital and global zones) from six EOMs. Coarse fibers had numerous large-sized mitochondrial profiles, often occurring in clusters. Granular fibers had fewer and smaller-sized profiles scattered across the fiber. Fine fibers had the most numerous, but smallest-sized mitochondrial profiles. Despite significant differences in group (fiber types) means for the mitochondrial variables, no single variable was sufficient for separating fiber types into distinct populations. Although a scattergram plot of two variables was sufficient to separate orbital zone fibers, a computer-generated, multivariate discriminant analysis was needed to separate the global zone fibers into distinct populations. These results will aid future studies on normal and pathological human EOM by providing a morphometric basis for identifying fiber types in the orbital and global zones.

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Section: Global Zone Fibersmentioning

confidence: 98%

mentioning

confidence: 99%

Mitochondrial morphometrics of histochemically identified human extraocular muscle fibers

1986

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“…Only four reports on the ultrastructure of ocular myopathy were found [71][72][73][74], The literature on normal ultrastructure of eye muscles is ex tensive [66][67][68][69][70], The first paper (1959) on electron microscopy of ocular myopathy [71] reports abnormal mitochondrial structure. In the I zone, the amount of endoplasmatic reticulum was decreased.…”

Section: Discussionmentioning

confidence: 99%

Ocular Myopathy

Bastiaensen¹,

Hommes²,

Stadhouders³

1974

Ophthalmologica

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“…The other, glo bal layer relies more on glycolytic metabolism and is com posed of fibres mainly involved in gaze movements [14], A similar arrangement has been found in both mam mals and man. although there is not always a general agreement concerning minor criteria on twitch fibre sub division [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…In the EOMs some fibres are characterized by a few features, both structural and innervational [14][15][16][17][18][19][20], which are not shared by other fibre types in skeletal muscles. Nevertheless, EOM function and metabolic activity do not differ very much from that of other skeletal muscles…”

Section: Introductionmentioning

confidence: 99%

Microcirculation of the Extra-Ocular Muscles of Rats

Pannarale

Onori

Gaudio

et al. 1991

Cells Tissues Organs

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Specific researches, employing corrosion casts, were performed on different skeletal muscles, but not on extra-ocular muscles (EOMs). The microvascular bed of EOMs was studied by the corrosion cast technique in the rat. Two histologically and physiologically different layers were present in the EOMs. On the whole the capillary pattern of EOMs was less dense than in the other skeletal muscles. The EOM orbital layer turned out to have a higher number of transverse anastomoses and tuning-fork divisions than the global layer had. These different microcirculatory patterns can be related with the physiological function and the anatomical situation of the EOMs.

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Structural Differences of Fast and Slow Fibers in Human Extraocular Muscle

Cited by 26 publications

References 13 publications

Mitochondrial morphometrics of histochemically identified human extraocular muscle fibers

Mitochondrial morphometrics of histochemically identified human extraocular muscle fibers

Ocular Myopathy

Microcirculation of the Extra-Ocular Muscles of Rats

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