Structural Design with Biological Methods: Optimality, Multi-functionality and Robustness

Paul, Debdas; Dehkordi, Layla Koohi Fayegh; Scheven, Malte von; Bischoff, Manfred; Radde, Nicole

doi:10.1007/978-3-319-46374-2_17

Cited by 3 publications

(3 citation statements)

References 35 publications

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“…Theoretical considerations show that such arrangements are not robust with respect to slight changes in parameter values. However, in real biological systems, we find that network-like arrangements of chemical reactions filter out noise without the need for fine-tuned parameters in order to perform well (Paul et al 2016). The possibility for a certain degree of "sloppiness" in the parameter values without negative consequences for the overall performance seems to be an important feature in real biochemical systems and their models (Gutenkunst et al 2007).…”

Section: Robustnessmentioning

confidence: 91%

“…Alon 2007). For example, particular arrangements of signal transduction pathways on the molecular level can contribute to robustness against noise (Paul et al 2016). Biochemical reactions arranged in a sequence need especially finetuned values of parameters (reaction rate constants) to work well in transmitting a signal, for example, from the outside of a cell to its nucleus.…”

Section: Robustnessmentioning

confidence: 99%

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A technomorphic conceptualisation of biological ‘constructions’ and their evolution

Drack¹,

Betz²

2022

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Here, we build on earlier work concerning notions of engineering design and investigate their conceptual connection to evolutionary biology. The basis for this work is an engineering design schema covering the central concepts of function, working principle and construction. Its relevance for evolutionary biology is explored by connecting these concepts to the so-called design space that is used in engineering optimisation. This tool makes it possible to distinguish various optima of performance and to visualise their robustness with respect to disturbances or changes in parameters. The robustness of morphological ‘constructions’ with regard to changes of shape is shown by means of examples from engineering and biology. The characteristics of various ‘landscapes’ in the design space is then related to the concept of evolvability, whereby we explore analogies between systems biology and morphology. A general property of phenotypes from the molecular to the organismal level seems to be that their ‘construction’ facilitates both their robustness and their exploration of the design space while maintaining the performance of the relevant functions at a high level.

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Section: Robustnessmentioning

confidence: 91%

Section: Robustnessmentioning

confidence: 99%

A technomorphic conceptualisation of biological ‘constructions’ and their evolution

Drack¹,

Betz²

2022

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“…The sum of all element contributions is equal to the degree of static indeterminacy. Details of the algorithm, further description and an example are given in [16], [18] and [19]. With this knowledge, it is possible to transfer the above considerations on adaptability of displacements and forces from system level to element level.…”

Section: Construction Details Of the Finite Element Modell; Source:mentioning

confidence: 99%

The implementation of adaptive elements into an experimental high‐rise building

et al. 2018

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The goal of this research project is to find an answer to today's most urgent social and ecological questions as the global population continuously increases and the available resources remain limited. As the central approach to the solution of this problem, adaptive elements will be included in the structure, the interior and the façade of an experimental 37 m tall building. This paper introduces the topic of adaptivity in building structures and provides an overview of the research topics applied in this globally unique adaptive high-rise building. Due to the complexity of research topics of this Collaborative Research Centre, this paper only covers the research concerning the experimental high-rise building.

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Robustness and filtering properties of ubiquitous signaling network motifs * *This work has been funded by the German Research Foundation (DFG) as part of the Transregional Collaborative Research Centre (SFB/Transregio) 141 Biological Design and Integrative Structures/project B05.

Paul

Radde

2016

IFAC-PapersOnLine

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Structural Design with Biological Methods: Optimality, Multi-functionality and Robustness

Cited by 3 publications

References 35 publications

A technomorphic conceptualisation of biological ‘constructions’ and their evolution

A technomorphic conceptualisation of biological ‘constructions’ and their evolution

The implementation of adaptive elements into an experimental high‐rise building

Robustness and filtering properties of ubiquitous signaling network motifs * *This work has been funded by the German Research Foundation (DFG) as part of the Transregional Collaborative Research Centre (SFB/Transregio) 141 Biological Design and Integrative Structures/project B05.

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