Structural design of a newly developed pediatric circulatory assist device for fontan circulation by using shape memory alloy fiber

Shiraishi, Yasuyuki; Sugai, Takashi; Yoshizawa, Makoto; Yambe, Tomoyuki; Yamada, Akihiro; Omran, M. H.; Shiga, Takuya; Kitano, Tomoya; Kamiya, K.; Mochizuki, Shuichi; Miura, Hidekazu; Homma, Dai; Yamagishi, Masaaki

doi:10.1109/iembs.2011.6092060

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…Yamada et al. are developing an implantable pulsatile device using peristaltic motion to move blood through the ECC using computer‐synchronized contraction of shape memory alloy fibers. Rodefeld et al.…”

Section: Discussionmentioning

confidence: 99%

Pressure–Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients

et al. 2015

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An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional Fontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, this study examined the hydraulic performance of 11 impeller prototypes with blade stagger or twist angles varying from 100 to 600 degrees. A refined range of twisted blade angles between 300 and 400 degrees with 20-degree increments was then selected, and four additional geometries were constructed and hydraulically evaluated. The prototypes met performance expectations and produced 3-31 mm Hg for flow rates of 1-5 L/min for 6000-8000 rpm. A regression analysis was completed with all characteristic coefficients contributing significantly (P< 0.0001). This analysis revealed that the impeller with 400 degrees of blade twist outperformed the other designs. The findings of the numerical model for 300-degree twisted case and the experimental results deviated within approximately 20%. In an effort to simplify the impeller geometry, this work advanced the design of this intravascular cavopulmonary assist device closer to preclinical animal testing.

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Section: Discussionmentioning

confidence: 99%

Pressure–Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients

et al. 2015

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“…We used a shape memory alloy fiber for the actuator of the pulmonary circulation assist device (BMF100, Toki Corporation, Japan) [11]- [14]. The diameter of fiber was 100μm.…”

Section: A Development Of the Circulatory Assist Devicementioning

confidence: 99%

“…The system can promote pulmonary flow pulsatility in the pediatric patients after Fontan procedure as shown in Fig. 2 [11]. We used the shape memory alloy fibers as the actuator of this device, the diameter of which was 100 μm (BMF100, Toki Corporation).…”

Section: Introductionmentioning

confidence: 99%

Peristaltic hemodynamics of a new pediatric circulatory assist system for Fontan circulation using shape memory alloy fibers

Yamada

Shiraishi

Miura³

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Fontan procedure is one of the common surgical treatments of congenital heart diseases. Patients with Fontan circulation have single ventricle in the systemic circulation with the total cavopulmonary connection. We have been developing a pulmonary circulatory assist device using shape memory alloy fibers for Fontan circulation with total cavopulmonary connection. It consisted of the shape memory alloy fibers, the diameter of which are 100 µm. The fibers could wrap the ePTFE conduit for Fontan TCPC connection from the outside. We designed the sequential motion control system for sophisticated pulmonary hemodynamics by the pulsatile flow generation. In order to achieve pulsatile flow assistance in pulmonary arterial system, we fabricated a mechanical structure by sequential contraction of shape memory alloy fibers. Then, we developed a sequential contraction controller for the assist system, which could reproduce the wall contractile velocity at 6.0 to 20.0 cm/sec. We examined hemodynamic characteristic of its function using a mock circulatory system, which consisted of two overflow tanks representing venous and pulmonary arterial pressures in Fontan circulation. As a result, the pulmonary circulation assist device with sequential contraction could achieve effective promotion of the pulsatility in pulmonary arterial flow.

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“…These fibers encircle the extra‐cardiac conduit and induce pulsatile flow into the TCPC. The shape memory alloy fibers are controlled using a special control system . Despite its novel approach using mechanical contraction, peristaltic motion may not adequately produce evenly divided pulsatile flow into the pulmonary arteries.…”

Section: New Mcs Devices Under Developmentmentioning

confidence: 99%

Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease

et al. 2016

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The use of mechanical circulatory support (MCS) devices is a viable therapeutic treatment option for patients with congestive heart failure. Ventricular assist devices, cavopulmonary assist devices, and total artificial heart pumps continue to gain acceptance as viable treatment strategies for both adults and pediatric patients as bridge-to-transplant, bridge-to-recovery, and longer-term circulatory support alternatives. We present a review of the current and future MCS devices for patients having congenital heart disease (CHD) with biventricular or univentricular circulations. Several devices that are specifically designed for patients with complex CHD are in the development pipeline undergoing rigorous animal testing as readiness experiments in preparation for future clinical trials. These advances in the development of new blood pumps for patients with CHD will address a significant unmet clinical need, as well as generally improve innovation of the current state of the art in MCS technology.

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Structural design of a newly developed pediatric circulatory assist device for fontan circulation by using shape memory alloy fiber

Cited by 5 publications

References 10 publications

Pressure–Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients

Pressure–Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients

Peristaltic hemodynamics of a new pediatric circulatory assist system for Fontan circulation using shape memory alloy fibers

Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease

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