Pressure–Flow Experimental Performance of New Intravascular Blood Pump Designs for Fontan Patients

Abstract

An intravascular axial flow pump is being developed as a mechanical cavopulmonary assist device for adolescent and adult patients with dysfunctional Fontan physiology. Coupling computational modeling with experimental evaluation of prototypic designs, this study examined the hydraulic performance of 11 impeller prototypes with blade stagger or twist angles varying from 100 to 600 degrees. A refined range of twisted blade angles between 300 and 400 degrees with 20-degree increments was then selected, and four additional geometries were constructed and hydraulically evaluated. The prototypes met performance expectations and produced 3-31 mm Hg for flow rates of 1-5 L/min for 6000-8000 rpm. A regression analysis was completed with all characteristic coefficients contributing significantly (P< 0.0001). This analysis revealed that the impeller with 400 degrees of blade twist outperformed the other designs. The findings of the numerical model for 300-degree twisted case and the experimental results deviated within approximately 20%. In an effort to simplify the impeller geometry, this work advanced the design of this intravascular cavopulmonary assist device closer to preclinical animal testing.

An experimental performance comparison of Newtonian and non-Newtonian fluids on a centrifugal blood pump

“…In this study, a dimensionless performance analysis is performed on the pressure and flow rate data to quantitatively compare the experimental hydrodynamic performance data from the blood pump experimental setup. 26 The dimensionless head (ψ) and flow rate (Φ) curves are formed by all data sets (pressure and flow rate) for all four rotational speeds and combined in one curve. The curves of dimensionless head (ψ) and hydraulic efficiency are plotted against dimensionless flow rate (Φ) can be seen in Figure 6.…”

Computational fluid dynamic simulations of a cavopulmonary assist device for failing Fontan circulation

“…There have been several proposals for cavopulmonary assist devices, including the viscous impeller pump, 3,4 dual-membrane umbrella cannula, 5,6 and microaxial pumps. [7][8][9] These devices work in the Fontan total cavopulmonary connection (TCPC) to decrease unwanted pressure losses induced by collision and mixing of superior vena cava (SVC) and inferior vena cava (IVC) flows, in addition to offsetting effects of any elevated PVR in the pulmonary vascular bed. Data suggest that a cavopulmonary assist device would need to provide 2 to 6 mm Hg pressure gain 3,10 in the central venous part of the Fontan pathway to overcome PVR and pulmonary venous pressures through mechanical means.…”

Newton Ti̇pi̇ Olmayan Akişkan Kullanarak Kalp Destek Pompasinin Performansinin Hesaplamali Akişkanlar Mekani̇ği̇ Yöntemi̇ İle İncelenmesi̇

“…C ψ sabiti basınç faktörü ve C Ф sabiti ise debi faktörüdür. Bu faktörlerin değerleri ise sırasıyla 1,2157x10 10 ve 1,5195x10 5 'dir [15].…”