Structural Design and Numerical Analysis of a Novel Biodegradable Zinc Alloy Stent

Background Biodegradable stents display insufficient scaffold performance due to their poor Young’s Modulus. In addition, the corresponding biodegradable materials harbor weakened structures during degradation processes. Consequently, such stents have not been extensively applied in clinical therapy. In this study, the scaffold performance of a patented stent and its ability to reshape damaged vessels during degradation process were evaluated. Methods A common stent was chosen as a control to assess the mechanical behavior of the patented stent. Finite element analysis was used to simulate stent deployment into a 40% stenotic vessel. A material corrosion model involving uniform and stress corrosion was implemented within the finite element framework to update the stress state following degradation. Results The results showed that radial recoiling ratio and mass loss ratio of the patented stent is 7.19% and 3.1%, respectively, which are definitely lower than those of the common stent with the corresponding values of 22.6% and 14.1%, respectively. Moreover, the patented stent displayed stronger scaffold performance in a corrosive environment and the plaque treated with patented stents had a larger and flatter lumen. Conclusion Owing to its improved mechanical performance, the novel biodegradable zinc alloy stent reported here has high potential as an alternative choice in surgery.

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“…3. The cooperation between the strutting ring and the link was described in a previous work [15] (Fig. 4).…”

Section: Methodsmentioning

confidence: 99%

Mechanical analysis of a novel biodegradable zinc alloy stent based on a degradation model

et al. 2019

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“…The cavitation gas volume fraction will increase during the gear meshing process, and the probability of cavitation will increase. CFD (Computational Fluid Dynamics) is a valuable tool for researchers to gain a better understanding of fluid systems and optimize their performance [59][60][61]. In this particular study, cavitation is observed primarily in the meshing area and the meshing gap area of the external meshing herringbone gear pump, as depicted in Fig.…”

Section: Influence Of Helix Angle On Cavitationmentioning

confidence: 98%

Research on Cavitation Characteristics and Influencing Factors of Herringbone Gear Pump

Yang,

Lee,

Lee

2024

CMES

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Cavitation is a common issue in pumps, causing a decrease in pump head, a fall in volumetric efficiency, and an intensification of outlet flow pulsation. It is one of the main hazards that affect the regular operation of the pump. Research on pump cavitation mainly focuses on mixed flow pumps, jet pumps, external spur gear pumps, etc. However, there are few cavitation studies on external herringbone gear pumps. In addition, pumps with different working principles significantly differ in the flow and complexity of the internal flow field. Therefore, it is urgent to study the cavitation characteristics of external herringbone gear pumps. Compared with experimental methods, visual research and cavitation area identification are achieved through computation fluid dynamic (CFD), and changing the boundary conditions and shape of the gear rotor is easier. The simulation yields a head error of only 0.003% under different grid numbers, and the deviation between experimental and simulation results is less than 5%. The study revealed that cavitation causes flow pulsation at the outlet, and the cavitation serious area is mainly distributed in the meshing gap and meshing area. Cavitation can be inhibited by reducing the speed, increasing the inlet pressure, and changing the helix angle can be achieved. For example, when the inlet pressure is 5 bar, the maximum gas volume fraction in the meshing area is less than 50%. These results provide a reference for optimizing the design and finding the optimal design parameters to reduce or eliminate cavitation.

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“…Zinc alloy stent is still in the preliminary stage of research, and there are defects of uneven degradation and many problems that have not been discovered yet [ 51 ]. The current methods to solve the mechanical properties and degradation problems of BDSs, in addition to develop new materials, designing structures of stents can also be considered [ 61 , 62 ] to improve radial stiffness, axial flexibility, and reduce foreshortening, etc. [ 63 , 64 , 65 ].…”

Section: Introduction To the Vascular Stentsmentioning

confidence: 99%

Structural Design of Vascular Stents: A Review

Pan

Han

2021

Micromachines

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Percutaneous Coronary Intervention (PCI) is currently the most conventional and effective method for clinically treating cardiovascular diseases such as atherosclerosis. Stent implantation, as one of the ways of PCI in the treatment of coronary artery diseases, has become a hot spot in scientific research with more and more patients suffering from cardiovascular diseases. However, vascular stent implanted into vessels of patients often causes complications such as In-Stent Restenosis (ISR). The vascular stent is one of the sophisticated medical devices, a reasonable structure of stent can effectively reduce the complications. In this paper, we introduce the evolution, performance evaluation standards, delivery and deployment, and manufacturing methods of vascular stents. Based on a large number of literature pieces, this paper focuses on designing structures of vascular stents in terms of “bridge (or link)” type, representative volume unit (RVE)/representative unit cell (RUC), and patient-specific stent. Finally, this paper gives an outlook on the future development of designing vascular stents.

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Structural Design and Numerical Analysis of a Novel Biodegradable Zinc Alloy Stent

Cited by 5 publications

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Mechanical analysis of a novel biodegradable zinc alloy stent based on a degradation model

Mechanical analysis of a novel biodegradable zinc alloy stent based on a degradation model

Research on Cavitation Characteristics and Influencing Factors of Herringbone Gear Pump

Structural Design of Vascular Stents: A Review

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