Cellular structures consist of foams, honeycombs, and lattices. Lattices have many outstanding properties over foams and honeycombs, such as lightweight, high strength, absorbing energy, and reducing vibration, which has been extensively studied and concerned. Because of excellent properties, lattice structures have been widely used in aviation, bio-engineering, automation, and other industrial fields. In particular, the application of additive manufacturing (AM) technology used for fabricating lattice structures has pushed the development of designing lattice structures to a new stage and made a breakthrough progress. By searching a large number of research literature, the primary work of this paper reviews the lattice structures. First, based on the introductions about lattices of literature, the definition and classification of lattice structures are concluded. Lattice structures are divided into two general categories in this paper: uniform and non-uniform. Second, the performance and application of lattice structures are introduced in detail. In addition, the fabricating methods of lattice structures, i.e., traditional processing and additive manufacturing, are evaluated. Third, for uniform lattice structures, the main concern during design is to develop highly functional unit cells, which in this paper is summarized as three different methods, i.e., geometric unit cell based, mathematical algorithm generated, and topology optimization. Forth, non-uniform lattice structures are reviewed from two aspects of gradient and topology optimization. These methods include Voronoi-tessellation, size gradient method (SGM), size matching and scaling (SMS), and homogenization, optimization, and construction (HOC). Finally, the future development of lattice structures is prospected from different aspects.

Percutaneous Coronary Intervention (PCI) is currently the most conventional and effective method for clinically treating cardiovascular diseases such as atherosclerosis. Stent implantation, as one of the ways of PCI in the treatment of coronary artery diseases, has become a hot spot in scientific research with more and more patients suffering from cardiovascular diseases. However, vascular stent implanted into vessels of patients often causes complications such as In-Stent Restenosis (ISR). The vascular stent is one of the sophisticated medical devices, a reasonable structure of stent can effectively reduce the complications. In this paper, we introduce the evolution, performance evaluation standards, delivery and deployment, and manufacturing methods of vascular stents. Based on a large number of literature pieces, this paper focuses on designing structures of vascular stents in terms of “bridge (or link)” type, representative volume unit (RVE)/representative unit cell (RUC), and patient-specific stent. Finally, this paper gives an outlook on the future development of designing vascular stents.

As the leading causes of global death, cardiovascular diseases are generally initiated by artery-related disorders such as atherosclerosis, thrombosis, and aneurysm. Although clinical treatments have been developed to rescue patients suffering from artery-related disorders, the underlying pathologies of these arterial abnormalities are not fully understood. Biofabrication techniques pave the way to constructing diseased artery in vitro models using human vascular cells, biomaterials, and biomolecules, which are capable of recapitulating arterial pathophysiology with superior performance compared with conventional planar cell culture and experimental animal models. This review discusses the critical elements in the arterial microenvironment which are important considerations for recreating biomimetic human arteries with the desired disorders in vitro. Afterward, conventionally biofabricated platforms for the investigation of arterial diseases are summarized, along with their merits and shortcomings, followed by a comprehensive review of advanced biofabrication techniques and the progress of their applications in establishing diseased artery models.

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In order to obtain scaffold that can meet the therapeutic effect, researchers have carried out research on irregular porous structures. However, there are deficiencies in the design method of accurately controlling the apparent elastic modulus of the structure at present. Natural bone has a gradient porous structure. However, there are few studies on the mechanical property advantages of gradient bionic bone scaffold. In this paper, an improved method based on Voronoi-tessellation is proposed. The method can get controllable gradient scaffolds to fit the modulus of natural bone, and accurately control the apparent elastic modulus of porous structure, which is conducive to improving the stress shielding. To verify the designed structure can be fabricated by additive manufacturing, several designed models are obtained by SLM and EBM. Through finite element analysis (FEA), it is verified that the irregular porous structure based on Voronoi-tessellation is more stable than the traditional regular porous structure of the same structure volume, the same pore number and the same material. Furthermore, it is verified that the gradient irregular structure has a better stability than the non-gradient structure. An experiment is conducted successfully to verify the stability performance got by FEA. In addition, a dynamic impact FEA is also performed to simulate impact resistance. The result shows that the impact resistance of the regular porous structure, the irregular porous structure and the gradient irregular porous structure becomes better in turn. The mechanical property verification provides a theoretical basis for the structural design of gradient irregular porous bone tissue engineering scaffolds.