Structural connectome and connectivity lateralization of the multimodal vestibular cortical network

Indovina, Iole; Bosco, Gianfranco; Riccelli, Roberta; Maffei, Vincenzo; Lacquaniti, Francesco; Passamonti, Luca; Toschi, Nicola

doi:10.1016/j.neuroimage.2020.117247

Cited by 35 publications

(61 citation statements)

References 95 publications

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“…An MR tractography study of the connections of PIC (Wirth et al 2018) showed no connectivity with any of the established components of the human motor system. Nonetheless, PIC may be connected with SMA: this is evident in the functional connectivity data of both Serra et al (2019) and Indovina et al (2020). Connectivity between PIC and the dorsomedial region in and around the ascending cingulate sulcus (see discussion of pCi and hPEc below), has also been suggested (Indovina et al 2020).…”

Section: Function Of Csv and Mcsvmentioning

confidence: 93%

“…Nonetheless, PIC may be connected with SMA: this is evident in the functional connectivity data of both Serra et al (2019) and Indovina et al (2020). Connectivity between PIC and the dorsomedial region in and around the ascending cingulate sulcus (see discussion of pCi and hPEc below), has also been suggested (Indovina et al 2020). PIC was shown by Smith et al (2018), with both structural and functional MRI methods, to have connectivity with CSv, although this is also not evident in the MRI tractography of Wirth et al (2018), and macaque VPS appears to be connected with mCSv (De Castro et al 2021).…”

Section: Function Of Csv and Mcsvmentioning

confidence: 94%

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Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Smith

2021

Brain Struct Funct

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The response properties, connectivity and function of the cingulate sulcus visual area (CSv) are reviewed. Cortical area CSv has been identified in both human and macaque brains. It has similar response properties and connectivity in the two species. It is situated bilaterally in the cingulate sulcus close to an established group of medial motor/premotor areas. It has strong connectivity with these areas, particularly the cingulate motor areas and the supplementary motor area, suggesting that it is involved in motor control. CSv is active during visual stimulation but only if that stimulation is indicative of self-motion. It is also active during vestibular stimulation and connectivity data suggest that it receives proprioceptive input. Connectivity with topographically organized somatosensory and motor regions strongly emphasizes the legs over the arms. Together these properties suggest that CSv provides a key interface between the sensory and motor systems in the control of locomotion. It is likely that its role involves online control and adjustment of ongoing locomotory movements, including obstacle avoidance and maintaining the intended trajectory. It is proposed that CSv is best seen as part of the cingulate motor complex. In the human case, a modification of the influential scheme of Picard and Strick (Picard and Strick, Cereb Cortex 6:342–353, 1996) is proposed to reflect this.

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Section: Function Of Csv and Mcsvmentioning

confidence: 93%

Section: Function Of Csv and Mcsvmentioning

confidence: 94%

Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Smith

2021

Brain Struct Funct

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“…The cytoarchitecture of OP2 is symmetrical (Eickhoff et al, 2006b). Studies of the region's structural connectivity have shown mixed results with right (Wirth et al, 2018;Raiser et al, 2020), or left-lateralised patterns of cortico-cortical connectivity (Indovina et al, 2020). A functional connectivity study showed OP2 and neighbouring regions had both symmetric and lateralised cortico-cortical connectivity (Kirsch et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…The human cortical vestibular network is involved in higher order vestibular functions such as the perception of self-motion, judgements regarding verticality as well as balance control and spatial navigation (Lopez and Blanke, 2011). OP2 is well connected to this network (zu Eulenburg et al, 2012;Wirth et al, 2018;Indovina et al, 2020), and the area's centrality in the network predicts the existence of subregions further connected to vestibular brain areas involved in processing higherorder visuo-vestibular functions.…”

Section: Discussionmentioning

confidence: 99%

“…OP2 is a core region within the human cortical vestibular network on the basis of its location (Eickhoff et al, 2006b(Eickhoff et al, , 2006c, structural connectivity (Wirth et al, 2018;Indovina et al, 2020), and functional responses (Eickhoff et al, 2006c;zu Eulenburg et al, 2012). Here we define its functional anatomy by studying distinct patterns of connectivity measured using functional MRI.…”

Section: Discussionmentioning

confidence: 99%

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The human vestibular cortex: functional anatomy, connectivity and the effect of vestibular disease

Ibitoye

Mallas

Bourke

et al. 2021

Preprint

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Area OP2 in the posterior peri-sylvian cortex has been proposed to be the core human vestibular cortex. We defined the functional anatomy of OP2 using spatially constrained independent component analysis of functional MRI data from the Human Connectome Project. Ten distinct subregions were identified. Most subregions showed significant connectivity to other areas with vestibular function: the parietal opercula, the primary somatosensory cortex, the supracalcarine cortex, the left inferior parietal lobule and the anterior cingulate cortex. OP2 responses to vestibular and visual-motion were analysed in 17 controls and 17 right-sided unilateral vestibular lesion patients (vestibular neuritis) who had previously undergone caloric and optokinetic stimulation during functional MRI. In controls, a posterior part of right OP2 showed: (a) direction-selective responses to visual motion; and (b) activation during caloric stimulation that correlated positively with perceived self-motion, and negatively with visual dependence. Patients showed abnormal OP2 activity, with an absence of visual or caloric activation of the healthy ear and no correlations with dizziness or visual dependence despite normal brainstem responses to caloric stimulation (slow-phase nystagmus velocity). A lateral part of right OP2 showed activity that correlated with chronic dizziness (situational vertigo) in patients. Our results define the functional anatomy of OP2 in health and disease. A posterior subregion of right OP2 shows strong functional connectivity to other vestibular regions and a visuo-vestibular profile that becomes profoundly disrupted after vestibular disease. In vestibular patients, a lateral subregion of right OP2 shows responses linked to the challenging long-term symptoms which define poorer clinical outcomes.

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Left parietal involvement in motion sickness susceptibility revealed by multimodal magnetic resonance imaging

Sakai

Harada

Larroque

et al. 2021

Human Brain Mapping

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Susceptibility to motion sickness varies greatly across individuals. However, the neural mechanisms underlying this susceptibility remain largely unclear. To address this gap, the current study aimed to identify the neural correlates of motion sickness susceptibility using multimodal MRI. First, we compared resting-state functional connectivity between healthy individuals who were highly susceptible to motion sickness (N = 36) and age/sex-matched controls who showed low susceptibility (N = 36).Seed-based analysis revealed between-group differences in functional connectivity of core vestibular regions in the left posterior Sylvian fissure. A data-driven approach using intrinsic connectivity contrast found greater network centrality of the left intraparietal sulcus in high-rather than in low-susceptible individuals. Moreover, exploratory structural connectivity analysis uncovered an association between motion sickness susceptibility and white matter integrity in the left inferior frontooccipital fasciculus. Taken together, our data indicate left parietal involvement in motion sickness susceptibility.

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Structural connectome and connectivity lateralization of the multimodal vestibular cortical network

Cited by 35 publications

References 95 publications

Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

Cortical visual area CSv as a cingulate motor area: a sensorimotor interface for the control of locomotion

The human vestibular cortex: functional anatomy, connectivity and the effect of vestibular disease

Left parietal involvement in motion sickness susceptibility revealed by multimodal magnetic resonance imaging

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