Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis

Park, Hae Chul; Hong, Sung Kook; Kim, Hyung Seok; Kim, Seok Hyung; Yoon, Eun Ja; Kim, Cheol-Hee; Miki, Naomasa; Huh, Tae Lin

doi:10.1016/s0304-3940(99)00940-4

Cited by 83 publications

(51 citation statements)

References 16 publications

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“…Why the mammalian brain needs two very similar glycolytic enzymes is not understood (Rottmann et al, 1987). The differential pattern of expression of aldolases A and C in brain is reminiscent of the shifting pattern of Hu expression during neuronal differentiation in mouse (Okano and Darnell, 1997), chicken (Wakamatsu and Weston, 1997), Xenopus (Perron et al, 1999), and zebrafish (Park et al, 2000). It suggests that sets of RNA-binding proteins in varying composition in ribonucleoprotein complexes (Keene and Tenembaum, 2002) may have differing effects on differentiation in subsets of neurons.…”

Section: Discussionmentioning

confidence: 99%

Aldolases A and C Are Ribonucleolytic Components of a Neuronal Complex That Regulates the Stability of the Light-Neurofilament mRNA

Cañete‐Soler¹,

Reddy²,

Tolan³

et al. 2005

J. Neurosci.

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Section: Discussionmentioning

confidence: 99%

Aldolases A and C Are Ribonucleolytic Components of a Neuronal Complex That Regulates the Stability of the Light-Neurofilament mRNA

Cañete‐Soler¹,

Reddy²,

Tolan³

et al. 2005

J. Neurosci.

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“…Since beta III tubulin is expressed only in mature post-mitotic neurons, we have used markers like Hu and NeuroD to understand neuronal differentiation during regeneration. Both Hu protein, which is known to be expressed very early during neuronal differentiation in zebrafish (Kim et al, 1996;Park et al, 2000), and NeuroD, a marker for neuronally determined cells (Korzh et al, 1998), were used to show the nature and time of appearance of newly formed neurons in regenerating cord. Both uninjured and injured cords do express Hu protein (Fig.…”

Section: Neurogenesis: Expression Of Neuronal Markersmentioning

confidence: 99%

Cellular response after crush injury in adult zebrafish spinal cord

Hui

Dutta

Ghosh

2010

Developmental Dynamics

111

169

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*Zebrafish proves to be an excellent model system to study spinal cord regeneration because it can repair its disengaged axons and replace lost cells after injury, allowing the animal to make functional recovery. We have characterized injury response following crush injury, which is comparable to the mammalian mode of injury. Infiltrations of blood cells during early phases involve macrophages that are important in debris clearance and probably in suppression of inflammatory response. Unlike mammals where secondary injury mechanisms lead to apoptotic death of both neurons and glia, here we observe a beneficial role of apoptotic cell death. Injury-induced proliferation, presence of radial glia cells, and their role as progenitor all contribute to cellular replacement and successful neurogenesis after injury in adult zebrafish. Together with cell replacement phenomenon, there is creation of a permissive environment that includes the absence or clearance of myelin debris, presence of Schwann cells, and absence of inflammatory response. Developmental Dynamics 239:2962-2979,

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“…Because atp6v0c2 showed neuronspecific expression in the zebrafish CNS, we next compared the temporal and spatial expression patterns of atp6v0c2 with those of HuC, which is a post-mitotic pan-neuronal marker in zebrafish (Kim et al, 1997;Park et al, 2000a). By the 3-somite stage (11 hpf), expression of HuC was detected in the primary neurons, including RohonBeard cells (Fig.…”

Section: Atp6v0c2 Is Specifically Expressed In the Zebrafish Cnsmentioning

confidence: 99%

Neuron‐specific expression of atp6v0c2 in zebrafish CNS

Chung

Kim

et al. 2010

Developmental Dynamics

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*Vacuolar ATPase (V-ATPase) is a multi-subunit enzyme that plays an important role in the acidification of a variety of intracellular compartments. ATP6V0C is subunit c of the V 0 domain that forms the proteolipid pore of the enzyme. In the present study, we investigated the neuron-specific expression of atp6v0c2, a novel isoform of the V-ATPase c-subunit, during the development of the zebrafish CNS. Zebrafish atp6v0c2 was isolated from a genome-wide analysis of the zebrafish mib ta52b mutant designed to identify genes differentially regulated by Notch signaling. Whole-mount in situ hybridization revealed that atp6v0c2 is expressed in a subset of CNS neurons beginning several hours after the emergence of post-mitotic neurons. The ATP6V0C2 protein is co-localized with the presynaptic vesicle marker, SV2, suggesting that it is involved in neurotransmitter storage and/or secretion in neurons. In addition, the loss-of-function experiment suggests that ATP6V0C2 is involved in the control of neuronal excitability. Developmental Dynamics 239:2501-2508,

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Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis

Cited by 83 publications

References 16 publications

Aldolases A and C Are Ribonucleolytic Components of a Neuronal Complex That Regulates the Stability of the Light-Neurofilament mRNA

Aldolases A and C Are Ribonucleolytic Components of a Neuronal Complex That Regulates the Stability of the Light-Neurofilament mRNA

Cellular response after crush injury in adult zebrafish spinal cord

Neuron‐specific expression of atp6v0c2 in zebrafish CNS

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