Aldolases A and C Are Ribonucleolytic Components of a Neuronal Complex That Regulates the Stability of the Light-Neurofilament mRNA

Induction of Neuronal and Tumor-Related Genes by Adenovirus Type 12 E1A

“…12-1 cells also had greater expression levels of genes involved in neuronal development: C1-13 (10.6-fold), rS-Rex-b (9.2-fold), and neuronatin alpha (4.0-fold) (3,33,38,42,71). Other genes elevated in expression in 12-1 cells include those for the transmembrane receptor Robo1 (roundabout homolog 1, 4.9-fold) and the homeodomain transcription factor Nkx6.1 (3.5-fold), which play important roles in axon guidance and pathfinding (8, 10, 35, 50, 74); the type 1 cannabinoid receptor SKR6 (3.2-fold), which is involved in neuronal signal transmission (45); and the neuronal aldolase C (24.3-and 3.2-fold for two separate sequences), which is involved in glycolysis (20) and in the regulation of neurofilament light subunit (NF-L) expression (9). In contrast, only a single neuronal-like gene, that for sortilin, which functions as a neurotensin receptor in neuronal cells (46) or as a sorting protein in the glucose transporter Glut4 vesicles in fat and muscle cells (41), was identified with 3.2-fold greater expression in 12-1sm cells.…”

Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant

“…Aldolase is involved in binding interactions with several other proteins, but the functional role of aldolase in these interactions has not been fully characterized. Aldolases A and C have been found to bind to the neurofilament light-chain mRNA in neurons (Cañ ete-Soler et al, 2005). Aldolase A associates with the vacuolar H + -ATPase (Lu et al, 2001) and is thought to mediate its assembly, expression, and activity as a proton pump (Lu et al, 2004).…”

Purification, identification and characterization of mammalian endoribonucleases that degrade c-myc mRNA in vitro.

“…These studies suggest that a neuronal-specific mechanism, in response to an extracellular stimulus, functions to activate the endoribonucleolytic activity of aldolases A and C thus promoting cleavage of the NF-L mRNA transcript (Canete-Soler et al 2005). This model of mRNA regulation is similar to the Given the wide-ranging implications of c-myc overexpression in carcinogenesis (Ioannidis et al 2004), the link between signal transduction pathways/ endoribonuclease activation, and the numerous mammalian proteins that exhibit multiple functions including endoribonucleolytic activity, elucidating the identity of the native mammalian endoribonuclease(s) is of prime importance.…”

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