Structural commonality of C1q TNF‐related proteins and their potential to activate relaxin/insulin‐like family peptide receptor 1 signalling pathways in cancer cells

Klonisch, Thomas; Głogowska, Aleksandra; Thanasupawat, Thatchawan; Burg, Maxwell; Krcek, Jerry; Pitz, Marshall; Jaggupilli, Appalaraju; Chelikani, Prashen; Wong, G. William; Hombach‐Klonisch, Sabine

doi:10.1111/bph.13559

Cited by 30 publications

(32 citation statements)

References 63 publications

(115 reference statements)

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“…CTRP8 in addition to forming homotrimers, forms heteromeric complexes with CTRP1, CTRP9 and CTRP10. It effectively activates GPCR relaxin/insulin like family peptide receptor (RXFP1 receptor) to enhance the motility of the glioblastoma through regulating the activity of cathepsin B [15] . CTRPs, as secreted hormones are subjected to multiple functionally relevant post-translational modifications at their highly conserved residues.…”

Section: Characteristic Descriptionmentioning

confidence: 99%

Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system

Wang¹,

Zhao²,

Liu³

et al. 2017

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How to cite this article: Wang YJ, Zhao JL, Lau WB, Liu J, Guo R, Ma XL. Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system. Vessel Plus 2017;1:202-12.Increasing evidence indicates that adipose tissue-originated cytokines mediate communication between obesity-related exogenous molecules and the molecular events that initiate the metabolic syndrome and the inflammatory responses in the cardiovascular system (CVS). Adipose tissue-derived cytokines including the C1q/tumor necrosis factor-related proteins (CTRPs), a 15-member family of novel adipokines, has attracted much interest due to its metabolic regulatory and anti-inflammatory effect and appear to play a pathophysiological role in metabolism and immunity. To date, 15 members of CTRP family have been identified and they also play a role in the CVS, especially as potent biomarkers or therapeutic targets for modulating metabolic or inflammatory functions. Therefore, this review will focus on the characteristics of CTRPs that influence cardiovascular function and on the potential of CTRPs as biomarkers and therapeutic targets. Key words:Adipose tissue-derived cytokines, adipokines, C1q/tumor necrosis factor-related proteins, metabolism, cardiovascular system, biomarker, therapeutic target ABSTRACTArticle history:

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Section: Characteristic Descriptionmentioning

confidence: 99%

Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system

Wang¹,

Zhao²,

Liu³

et al. 2017

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“…cTRP8 was reported to be involved in brain cancer (9). It was also demonstrated to enhance motility and matrix invasion by human glioblastoma cells (10). cTRP8-induced migration of human glioma cells was revealed to be inhibited by a small competitor peptide derived from c1QTNF6 (11).…”

Section: Introductionmentioning

confidence: 99%

C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells

Chen

Wang

et al. 2018

Int J Mol Med

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In the present study, proteins differentially expressed between gastric cancer tissue and para-tumoral normal gastric tissues were screened, and the function of the highly expressed protein c1QTNF6 in gastric carcinoma was investigated. The differential expression of mRNAs extracted from the tumor and adjacent tissues was analyzed using Genechip assay. An AGS si-c1QTNF6 cell line was constructed using shRNA-c1QTNF6 lentivirus. The cell invasion and migration ability of c1QTNF6-knockdown cells were determined by Transwell chamber migration and wound healing assays, respectively. The effects of c1QTNF6 on AGS cell cycle distribution and apoptosis were detected using a FACScan flow cytometer. The results demonstrated that the expression of 109 genes was increased and the expression of 129 was decreased in tumor tissues. Among these genes, the c1QTNF6 gene was highly expressed in tumor tissues and the AGS7901 cell line. c1QTNF6-knockdown decreased the cell growth, and the proliferative and migration ability, as well as increasing the apoptosis of gastric carcinoma cells. In addition, the number of AGS cells in the G2/M phase was significantly increased after 5 days of c1QTNF6-shRNA lentivirus infection. The results of the present study indicated that c1QTNF6 serves an important role in the development of gastric carcinoma. c1QTNF6 is involved in promoting the proliferation and migration, and in reducing the apoptosis of gastric carcinoma cells. These results provided a potential therapeutic target for the treatment of gastric carcinoma.

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“…In 2004, Wong et al characterized a novel family of adipose tissue-derived cytokines, collectively called adipokines, referred to as Complement C 1q T umor necrosis factor- R elated P roteins (CTRPs) (76), like adiponectin and tumor necrosis factor (TNF) these CTRPs all contain a C1q globular domain and are characterized together as the C1q/TNF superfamily (62). To date, this superfamily has been documented to have a wide range and opposing effects on metabolism, food intake, inflammation, tumor metastasis, apoptosis, vascular disorders, ischemic injury, and even sexual reproduction (7, 8, 25, 29, 30, 49, 51, 57, 62, 64, 68, 69, 74-76, 81, 84, 89). The purpose of this review is to carefully summarize the research that has been accomplished on one of these proteins, CTRP3.…”

Section: Introductionmentioning

confidence: 99%

C1q/TNF‐Related Protein 3 (CTRP3) Function and Regulation

Liu

Wright

Peterson

2017

Comprehensive Physiology

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As the largest endocrine organ, adipose tissue secretes many bioactive molecules that circulate in blood, collectively termed adipokines. Efforts to identify such metabolic regulators have led to the discovery of a family of secreted proteins, designated as C1q tumor necrosis factor (TNF)-related proteins (CTRPs). The CTRP proteins, adiponectin, TNF-alpha, as well as other proteins with the distinct C1q domain are collectively grouped together as the C1q/TNF superfamily. Reflecting profound biological potency, the initial characterization of these adipose tissue-derived CTRP factors finds wide-ranging effects upon metabolism, inflammation, and survival-signaling in multiple tissue types. CTRP3 (also known as CORS26, cartducin, or cartonectin) is a unique member of this adipokine family. In this review we provide a comprehensive overview of the research concerning the expression, regulation, and physiological function of CTRP3.

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Structural commonality of C1q TNF‐related proteins and their potential to activate relaxin/insulin‐like family peptide receptor 1 signalling pathways in cancer cells

Abstract: This article is part of a themed section on Recent Progress in the Understanding of Relaxin Family Peptides and their Receptors. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.10/issuetoc.

Cited by 30 publications

References 63 publications

Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system

Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system

C1QTNF6 is overexpressed in gastric carcinoma and contributes to the proliferation and migration of gastric carcinoma cells

C1q/TNF‐Related Protein 3 (CTRP3) Function and Regulation

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