Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system

Wang, Yajing; Zhao, Jianli; Liu, Jing; Guo, Rui; Ma, Xin‐Liang

doi:10.20517/2574-1209.2017.29

Cited by 13 publications

(15 citation statements)

References 68 publications

(104 reference statements)

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“…CTRP3 belongs to the family of the C1q/TNF protein, the common feature of which is a deep structural homology to adiponectin (ADPN). The latter is the best-known member of the CTRP family linked to the regulation of insulin sensitivity in tissues and an important and recognized biomarker of the evaluation of treatment effectiveness in obese patients with metabolic disorders [8,11]. The decrease of plasma concentration of this adipocytokine is strictly related to insulin resistance and type 2 DM development [8].…”

Section: Introductionmentioning

confidence: 99%

Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

Komosińska-Vassev

Olczyk

Kuźnik-Trocha

et al. 2019

JCM

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The aim of the study was to quantify the plasma concentration of omentin-1, neutrophil gelatinase-associated lipocalin (NGAL), and complement C1q tumor necrosis factor-related protein-3 (CTRP3) in obese patients with type 2 diabetes, before introducing insulin therapy, in relation to the plasma expression profiles of these regulatory molecules in the same patients after a 6-month insulin mixture therapy and in obese controls. Elevated plasma NGAL concentrations were found in type 2 diabetic patients as compared with subjects with metabolically healthy obesity. In turn, a 6-month insulin mixture therapy has shown a marked increase in the plasma concentration of omentine-1 and a significant decrease in plasma CTRP3 concentration in obese patients with type 2 diabetes, in relation to the values found in these patients before the implementation of insulin therapy. Insulin mixture therapy has also proved to be an important factor modifying the plasma profile of NGAL, increasing the concentration of this bioactive molecule in the plasma of patients with type 2 diabetes, after 6 months of its use, in relation to the concentration before treatment. The significant changes in the plasma profile of omentin-1, NGAL and CTRP3 during insulin therapy suggest their potential diagnostic utility in monitoring metabolic changes associated with the introduction of insulin treatment in type 2 diabetic patients.

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Section: Introductionmentioning

confidence: 99%

Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

Komosińska-Vassev

Olczyk

Kuźnik-Trocha

et al. 2019

JCM

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“…(20) Studies have shown increased levels of CTRP1 in T2D, prediabetes, coronary artery disease, congestive heart failure and atherosclerosis. (21,22) Although there is evidence on the protective role of CTRP1 in murine heart injuries, the exact role of CTRP1 in these conditions is still not fully understood and requires further studies. (23) CTRP5, another member of CTRPs family also expressed in a wide range of tissues including adipose tissue, eye, testis, skeletal muscle, brain, spleen, uterus, and ciliary epithelium but like CTRP1, adipose tissue is considered as the main secretor.…”

Section: Discussionmentioning

confidence: 99%

The circulating levels of CTRP5 and the ratio of CTRP1 to CTRP5 plasma levels are significant predictors for cIMT value in patients with type 2 diabetes

Majidi¹,

Omidifar²,

Emamgholipour³

et al. 2020

Preprint

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“…Muscles are primary targets for CTRP1 as it activates 5' AMP-activated protein kinase (AMPK) and the mitogen-activated protein kinase (MAPK) signaling pathways, promotes glucose uptake, ameliorates insulin resistance, and increases fat oxidation (20). The increased level of CTRP1 in T2D, prediabetes, coronary artery disease, congestive heart failure, and atherosclerosis is also reported in several studies (21,22). Although there is evidence on the protective role of CTRP1 in murine heart injuries, the exact role of CTRP1 in these conditions is still not fully understood and requires further studies (23).…”

Section: Introductionmentioning

confidence: 92%

“…CTRP5, another member of the CTRPs family is also expressed in a wide range of tissues including adipose tissue, eye, testis, skeletal muscle, brain, spleen, uterus, and ciliary epithelium. However, adipose tissue is considered as the main secretor (21). CTRP5 increases glucose uptake via stimulating incorporation of the glucose transporter 4 (GLUT4) into the plasma membrane by a mechanism dependent on AMPK phosphorylation.…”

Section: Introductionmentioning

confidence: 99%

The CTRP5 Circulating Levels and the Ratio of CTRP1 to CTRP5 in Plasma are Significant Predictors for Carotid Intima-Media Thickness(cIMT) value in Patients with type 2 diabetes: A Preliminary Study

Majidi

Emamgholipour

Omidifar

et al. 2020

Preprint

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Background: There is growing evidence that the C1qTNF-related protein (CTRP) family has a crucial role in the physiology and pathophysiology of metabolic disorders such as Type 2 Diabetes (T2D) and obesity. We sought to identify the association of CTRP1 and CTRP5 circulating levels with various obesity parameters such as visceral adipose tissue (VAT) thickness, visceral adiposity index (VAI), and with carotid intima-media thickness (cIMT) in patients with T2D and healthy subjects.Methods: This preliminary study consisted of men with T2D (n=42) and men without T2D (n=42) . cIMT and VAT thickness measurement was performed using an Accuvix XQ ultrasound. Circulating levels of CTRP1, CTRP5, and adiponectin were measured by enzyme-linked immunosorbent assay (ELISA).Results: CTRP-1 and CTRP1/CTRP5 ratio were markedly higher in patients with T2D compared to controls (p < 0001 and p = 0004 respectively). Interestingly, binominal logistic regression revealed that a higher circulating level of CTRP1 was associated with the presence of T2D (odds ratio [OR]: 1.009 [95% CI: 1.004-1.015]; P=.001). CTRP1 circulating levels were correlated with WHR, VAT, and HOMA-IR in the whole population study. Also, we observed that the ratio of CTRP1 to CTRP5 in plasma (β = 0.648, P=0.005) and CTRP5 circulating levels (β = 0.444, P=0.049) are significant predictors for cIMT value.Conclusions: Our results indicated that CTRP1 and CTRP5 concentrations were correlated with atherosclerosis in men with T2D and these adipokines might have a causal role for cardiometabolic risk in T2D.However, more studies in large sample sizes are required to clarify the role of CTRPs in T2D pathogenesis.

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Adipose tissue-derived cytokines, CTRPs as biomarkers and therapeutic targets in metabolism and the cardiovascular system

Cited by 13 publications

References 68 publications

Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in Obese Patients with Type 2 Diabetes During Insulin Therapy

The circulating levels of CTRP5 and the ratio of CTRP1 to CTRP5 plasma levels are significant predictors for cIMT value in patients with type 2 diabetes

The CTRP5 Circulating Levels and the Ratio of CTRP1 to CTRP5 in Plasma are Significant Predictors for Carotid Intima-Media Thickness(cIMT) value in Patients with type 2 diabetes: A Preliminary Study

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