Structural chromosomal abnormalities in couples with recurrent abortion in Egypt

Gaboon, Nagwa E. A.; Mohamed, Ahmed Ramy; Elsayed, Solaf M.; Zaki, Osama K.; Elsayed, Mohamed A.

doi:10.3906/sag-1310-5

Cited by 17 publications

(10 citation statements)

References 30 publications

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“…An increased tendency to early miscarriages in familial pericentric inversions has been well documented [26]. Table 2 shows that the distribution of structural chromosomal rearrangements in our study is similar to that reported worldwide Table 4 [27].…”

Section: Discussionsupporting

confidence: 87%

Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco

Houmaid¹,

Bekkay²,

Nassereddine³

et al. 2018

OJGen

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Purpose: A proportion of cases with repeated abortion are caused by chromosomal abnormality in one of the parents. The purpose of this study was to assess the frequency and nature of chromosomal aberrations that contribute to the occurrence of recurrent miscarriages. Several studies have been done to determine the role of chromosomal abnormalities in couples with recurrent spontaneous abortion in various countries. None of these studies was done in Morocco. Material and Methods: Cytogenetic study was done for 238 Moroccan couples who presented with repeated abortion at the Institut Pasteur, Casablanca, Morocco. Results: We found that the frequency of chromosomal abnormalities was not significantly different from that reported worldwide. Chromosomal abnormalities were detected in 13 (6.1%) of 238 couples. twelve of chromosomal abnormalities were structural and one of them were numerical. Conclusion: This study highlights the importance of constitutional cytogenetic exploration of couples with a history of repeated spontaneous abortion. Cytogenetic findings could provide valuable information for genetic counseling and allow monitoring of future pregnancies by prenatal diagnosis in couples with a history of recurrent miscarriage.

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Section: Discussionsupporting

confidence: 87%

Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco

Houmaid¹,

Bekkay²,

Nassereddine³

et al. 2018

OJGen

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“…Therefore, we identified that 69 couples (11.00%) had chromosomal abnormalities. This frequency is comparable to that reported in Iran (11.68%) [15], Italy (9.66%) [16], the Netherlands (9.46%) [16], Sultanate of Oman (8.68%) [17], Switzerland (7.29%) [16], Saudi Arabia (7.10%) [18,19], Egypt (6.40%) [20], Mexico (5.83%) [16,21], Belgium (5.34%) [22], Pakistan (5.33%) [23], Argentina (5.28%) [24], Brazil (5.09%) [25], the Philippines (5.06%) [26], India (4.90%) [27][28][29], Japan (4.54%) [30], Turkey (4.21%) [16,31], France (4.14%) [16], Tunisia (4.07%) [32], and the UK (3.52%) [33]. But it is significantly higher than that identified in China (2.98%, P = 0.048) [34] and in the USA (2.96%; P = 0.048) [35].…”

Section: Discussionsupporting

confidence: 85%

Chromosomal abnormalities in couples with recurrent spontaneous miscarriage: a 21-year retrospective study, a report of a novel insertion, and a literature review

Elkarhat

Kindil

Zarouf

et al. 2018

J Assist Reprod Genet

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The aim of this study is to evaluate the frequency and nature of chromosomal abnormalities in Moroccan couples with recurrent spontaneous miscarriage (RSM). In addition, the data were compared with those reported elsewhere in order to give a global estimation of chromosomal abnormalities frequencies. Methods The study was performed for all couples with RSM who were referred to the cytogenetic department, Pasteur Institute of Morocco, from different hospitals in Morocco between 1996 and 2016. Cytogenetic analysis was performed according to the standard method. Results Among 627 couples with RSM, the chromosomal abnormalities were identified in 11.00% of couples, with chromosomal inversions in 4.30%, reciprocal translocations in 2.71%, Robertsonian translocations in 1.43%, and deletion, isochromosome, and insertion in 0.15% each. The insertion identified [46,XX,ins(6)(p24q21q27)] is new, and is the fourth reported in association with RSM. The mosaic karyotypes were observed in 0.64%, polymorphic variants were identified in 1.27%, and numerical aneuploidy was observed in 0.15%. In regrouping our results with those in 27 other studies already published in 21 different countries, we obtained the frequency of chromosomal abnormalities in couple with RSM to be 5.16% (991/19197 couples). The reciprocal translocation was the most frequent with 2.50%, followed by Robertsonian translocation 0.83% and inversions 0.77%. The other types of chromosomal abnormalities were present with 0.98% in the world. Conclusion This data showed that the frequency of chromosomal abnormalities in Moroccan couples with RSM is 11.00%, and in regrouping our results with other studies, the frequency changes to 5.16%.

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“…However, samples with the aforementioned disorders that may injure the fetal brain structures had been excluded (Waldorf and McAdams, 2013). Fetal chromosomal abnormality, on the other hand, may cause significant congenital anomalies and mental retardation in infant, if the pregnancy continues to term (Gaboon et al, 2015). However, 3.0 T MR pre-scanning had been conducted by pediatric neuro-radiologist to ensure that the developmental status of the brain structures, such as the size of the cerebrum, developmental status of cerebral cortex, lateral ventricle, and corpus callosum, was anatomically normal.…”

Section: Discussionmentioning

confidence: 99%

Development of the human fetal hippocampal formation during early second trimester

Shi

et al. 2015

NeuroImage

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Development of the fetal hippocampal formation has been difficult to fully describe because of rapid changes in its shape during the fetal period. The aims of this study were to: (1) segment the fetal hippocampal formation using 7.0 T MR images from 41 specimens with gestational ages ranging from 14 to 22 weeks and (2) reveal the developmental course of the fetal hippocampal formation using volume and shape analyses. Differences in hemispheric volume were observed, with the right hippocampi being larger than the left. Absolute volume changes showed a linear increase, while relative volume changes demonstrated an inverted-U shape trend during this period. Together these exhibited a variable developmental rate among different regions of the fetal brain. Different sub-regional growth of the fetal hippocampal formation was specifically observed using shape analysis. The fetal hippocampal formation possessed a prominent medial–lateral bidirectional shape growth pattern during its rotation process. Our results provide additional insight into 3D hippocampal morphology in the assessment of fetal brain development and can be used as a reference for future hippocampal studies.

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Structural chromosomal abnormalities in couples with recurrent abortion in Egypt

Cited by 17 publications

References 30 publications

Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco

Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco

Chromosomal abnormalities in couples with recurrent spontaneous miscarriage: a 21-year retrospective study, a report of a novel insertion, and a literature review

Development of the human fetal hippocampal formation during early second trimester

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