Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco

Abstract

Purpose: A proportion of cases with repeated abortion are caused by chromosomal abnormality in one of the parents. The purpose of this study was to assess the frequency and nature of chromosomal aberrations that contribute to the occurrence of recurrent miscarriages. Several studies have been done to determine the role of chromosomal abnormalities in couples with recurrent spontaneous abortion in various countries. None of these studies was done in Morocco. Material and Methods: Cytogenetic study was done for 238 Moroccan couples who presented with repeated abortion at the Institut Pasteur, Casablanca, Morocco. Results: We found that the frequency of chromosomal abnormalities was not significantly different from that reported worldwide. Chromosomal abnormalities were detected in 13 (6.1%) of 238 couples. twelve of chromosomal abnormalities were structural and one of them were numerical. Conclusion: This study highlights the importance of constitutional cytogenetic exploration of couples with a history of repeated spontaneous abortion. Cytogenetic findings could provide valuable information for genetic counseling and allow monitoring of future pregnancies by prenatal diagnosis in couples with a history of recurrent miscarriage.

Chromosomal Aberrations in 224 Couples with Recurrent Pregnancy Loss

“…The incidence of chromosomal abnormalities was higher among females (7.14%) compared to males (5.35%); some studies reported such difference to be statistically significant[ 25 29 ] whereas others, including the current study, did not find the difference to be of statistical significance ( P = 0.435). [ 30 31 ] This higher female frequency may be explained by the fact that chromosomal anomalies compatible with fertility in females may be combined with sterility in males.…”

“…[ 28 34 ] Reciprocal translocations were the most commonly identified balanced chromosomal aberrations in couples with RPL, in accord with previous studies. [ 20 23 25 29 ] If one partner of a couple carries a balanced chromosomal translocation, the probability of miscarriage is nearly doubled. [ 38 ]…”

“…Robertsonian translocations were less frequently encountered than reciprocal translocations, which agrees with published reports. [ 20 23 25 29 ] Robertsonian translocations carry reproductive risks that are dependent on the chromosomes involved and the sex of the carrier. For carriers of the most common Robertsonian translocation der(13;14), the risk for miscarriage is approximately 15%.…”

Epidemiological and diagnostic aspects of spontaneous miscarriage in the department of gynecology-obstetric of the university hospital of Treichville in Abidjan

“…In all cases, this cytogenetic study of the abortion product and the karyotype of the parents is necessary if we want to prevent the CHF repeatedly by proposing genetic counseling to infertile couples. 2,9 The absence of histological abnormality in our study accounts for nearly 40% of the cases. Infectious causes such as malaria must be mentioned in the context of fever in the first trimester of pregnancy in tropical environments.…”

“…The first-quarter miscarriage is one of the main reasons for consultation with gynecological emergencies, since it complicates 10 to 25% of pregnancies and will affect about 25% of women during their genital life. 1,2 In spite of this frequency, doctors as well as patients often do not attach great importance to it, which is why there is little study devoted to it. 3 The question that any doctor should ask when faced with a first miscarriage is this an ordinary accident in the woman's obstetric life or the beginning of a series of spontaneous abortions to come?…”