Structural characterization of an acetylated glucomannan with antiinflammatory activity and gastroprotective property from Cyrtopodium andersonii

Parente, José Paz; Adão, Camila Rodrigues; Silva, Bernadete P. da; Tinoco, Luzineide W.

doi:10.1016/j.carres.2014.03.021

Cited by 25 publications

(12 citation statements)

References 26 publications

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“…A polysaccharide with similar structure was found in the dried stem of Dendrobium officinale , which had a backbone of 1,4-linked β- d -Man and β- d -Glc, with branches at O-6 consisting of terminal and 1,3-linked Man, 1,3-linked Glc, and a small proportion of arabinofuranosyl residues at the terminal position [17]. An acetylated glucomannan was also obtained from Cyrtopodium andersonii , which had a backbone of 1,4-linked β- d -Man and β- d -Glc and substituted by acetyl groups at C-2 of the 1,4-linked β- d -Man units [18].…”

Section: Resultsmentioning

confidence: 99%

Cholesteryl-Modification of a Glucomannan from Bletilla striata and Its Hydrogel Properties

et al. 2014

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A glucomannan-type polysaccharide, named BSP, was obtained from the tubers of Bletilla striata by ultrasonic-assisted extraction, ethanol precipitation, deproteination and gel-permeation chromatography. HPLC analysis revealed that BSP contained mannose and glucose in the molar ratio of 3.5:1. Its molecular weight (Mw) was estimated to be 20 kDa. Methylation analysis, FT-IR and NMR analyses indicated that BSP consisted of (1→4)-linked β-D-glucopyranosyl residues and (1→4)-linked β-D-mannopyranosyl residues. Cholesteryl succinate was linked to BSP to make it more amphiphilic and the degree of substitution of cholesteryl succinate-BSP was 3.2%. The critical micelle concentration of modified BSP was 0.001 mg/mL, suggesting it could self-assemble into nanoparticles in aqueous solution.

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Section: Resultsmentioning

confidence: 99%

Cholesteryl-Modification of a Glucomannan from Bletilla striata and Its Hydrogel Properties

et al. 2014

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“…In pectic polysaccharides, acetyl groups were generally substituted at HO-2 or HO-3 with GalpA units (Correa-Ferreira et al, 2018;de Oliveira et al, 2018;Nascimento et al, 2013). Regarding neutral polysaccharides, acetyl groups had substitution sites at C-2 of (1→4)-linked β-D-Manp units (Parente et al, 2014;L. C. Wang, Wu, et al, 2018).…”

Section: Influence Of Functional Groupmentioning

confidence: 99%

“…Moreover, polysaccharides with low degree of acetylation (DA) were supposed to behave more effectively in alleviating ethanol or HCl-/ethanol-induced GL in vivo. Parente et al (2014) stated that an acetylated glucomannan (DA of 14.6%) could decline HCl-/ethanol-induced GL in mice by 66.7% at the dose of 100 mg/kg. In contrast, 30 mg/kg of a pectic polysaccharide (DA of 5.5%) reflected an inhibition rate of 65.0% to ethanol-induced GL in rats (Correa-Ferreira et al, 2018).…”

Section: Influence Of Functional Groupmentioning

confidence: 99%

Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship

Wang

Yin

et al. 2022

Food Frontiers

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Polysaccharides from natural sources have the potentials in being used as substitutes of chemosynthetic drugs for gastroprotection because of its safety and efficacy.For giving a better understanding of gastroprotective polysaccharides, the research progress on preparation, structure, bioactivity, and their action mechanism is comprehensively summarized in this review. Moreover, the structure-activity relationship of gastroprotective polysaccharides is discussed. Accumulating evidence has indicated that natural polysaccharides, which were widely prepared by water extraction and column chromatography purifications, exhibited gastroprotective effects in vitro and in vivo. The action mechanism might be related to gastric secretions, promotion of gastric defensive factor releases, antioxidation, anti-inflammatory, antiapoptosis, and facilitation of proliferation. Phenolic compounds, molecular weight and conformation, monosaccharide composition, backbone structure and side chain, and functional group have great influences on the gastroprotective activities of polysaccharides. This review gives comprehensive guidance to the exploitation and application of natural polysaccharides in food and other industries for gastroprotection.

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“…The phytochemical and biological investigations of this family has been mainly conducted in relation with their traditional uses and focused on a large number of Asian orchids from the genus Arundina, Bletilla, Dendrobium, Gastrodia and Pleione at the expense of the New World orchids In fact, the first report on a phytochemical study of South American orchids was in the late 1990s and was mainly focused on species in the genus Scaphyglottis [1-3], Maxillaria [4][5][6][7] and Cyrtopodium [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…and C. andersonnii R.Br. for their polysaccharidic content, which displays anti-inflammatory and gastroprotective activities [8,10], and C. macrobulbon (La Llave & Lex.) G.A.…”

Section: Introductionmentioning

confidence: 99%

Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum

Auberon¹,

Olatunji²,

Herbette

et al. 2016

Molecules

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Abstract:We report the first phytochemical study of the neotropical orchid Cyrtopodium paniculatum. Eight new compounds, including one phenanthrene 1, one 9,10-dihydro-phenanthrene 2, one hydroxybenzylphenanthrene 3, two biphenanthrenes 4-5, and three 9,10 dihydrophenanthrofurans 6-8, together with 28 known phenolic compounds, mostly stilbenoids, were isolated from the CH 2 Cl 2 extract of its leaves and pseudobulbs. The structures of the new compounds were established on the basis of extensive spectroscopic methods.

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Structural characterization of an acetylated glucomannan with antiinflammatory activity and gastroprotective property from Cyrtopodium andersonii

Cited by 25 publications

References 26 publications

Cholesteryl-Modification of a Glucomannan from Bletilla striata and Its Hydrogel Properties

Cholesteryl-Modification of a Glucomannan from Bletilla striata and Its Hydrogel Properties

Gastroprotective polysaccharide from natural sources: Review on structure, mechanism, and structure–activity relationship

Chemical Constituents from the Aerial Parts of Cyrtopodium paniculatum

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