Structural characterization and thermal behavior of a gum extracted from Ferula assa foetida L.

Saeidy, Sima; Nasirpour, Ali; Keramat, Javad; Desbrières, Jacques; Cerf, Didier Le; Pierre, Guillaume; Delattre, Cédric; Laroche, Céline; Baynast, Hélène de; Ursu, Alina-Violeta; Marcati, Alain; Djelveh, Gholamreza; Michaud, Philippe

doi:10.1016/j.carbpol.2017.10.096

Cited by 33 publications

(14 citation statements)

References 37 publications

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“…Asafoetida is an oleo-gum-resin isolated from Ferula assa-foetida root [ 20 ]. Raw medicinal materials were purchased from Beijing Dongzhou Traditional Chinese Medicine Clinic Co., Ltd. (Batch No.…”

Section: Methodsmentioning

confidence: 99%

“…Ferula assa-foetida belongs to Umbelliferae (Apiaceae) family, an ancient traditional phytomedicine, mainly distributed in the Xinjiang Uygur Autonomous Region of China, India, and Iran [ 18 – 20 ]. Its oleo gum resin, commonly known as Asafoetida (ASF) (named “AWEI” in Chinese Pharmacopoeia) [ 21 , 22 ], has been report to possess high medicinal value.…”

Section: Introductionmentioning

confidence: 99%

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Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway

et al. 2022

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Background Alzheimer's Disease (AD) is a serious neurodegenerative disease and there is currently no effective treatment for AD progression. The use of TCM as a potential treatment strategy for AD is an evolving field of investigation. Asafoetida (ASF), an oleo-gum-resin isolated from Ferula assa-foetida root, has been proven to possess antioxidative potential and neuroprotective effects, which is closely associated with the neurological disorders. However, the efficacy and further mechanisms of ASF in AD experimental models are still unclear. Methods A cognitive impairment of mouse model induced by scopolamine was established to determine the neuroprotective effects of ASF in vivo, as shown by behavioral tests, biochemical assays, Nissl staining, TUNEL staining, Immunohistochemistry, western blot and qPCR. Furthermore, the PC12 cells stimulated by H2O2 were applied to explore the underlying mechanisms of ASF-mediated efficacy. Then, the UPLCM analysis and integrated network pharmacology approach was utilized to identified the main constitutes of ASF and the potential target of ASF against AD, respectively. And the main identified targets were validated in vitro by western blot, qPCR and immunofluorescence staining. Results In vivo, ASF treatment significantly ameliorated cognitive impairment induced by scopolamine, as evidenced by improving learning and memory abilities, and reducing neuronal injury, cholinergic system impairment, oxidative stress and apoptosis in the hippocampus of mice. In vitro, our results validated that ASF can dose-dependently attenuated H2O2-induced pathological oxidative stress in PC12 cells by inhibiting ROS and MDA production, as well as promoting the activities of SOD, CAT, GSH. We also found that ASF can significantly suppressed the apoptosis rate of PC12 cells increased by H2O2 exposure, which was confirmed by flow cytometry analysis. Moreover, treatment with ASF obviously attenuated H2O2-induced increase in caspase-3 and Bax expression levels, as well as decrease in Bcl-2 protein expression. KEGG enrichment analysis indicated that the PI3K/Akt/GSK3β/Nrf2 /HO-1pathway may be involved in the regulation of cognitive impairment by ASF. The results of western blot, qPCR and immunofluorescence staining of vitro assay proved it. Conclusions Collectively, our work first uncovered the significant neuroprotective effect of ASF in treating AD in vivo. Then, we processed a series of vitro experiments to clarify the biological mechanism action. These data demonstrate that ASF can inhibit oxidative stress induced neuronal apoptosis to foster the prevention of AD both in vivo and in vitro, and it may exert the function of inhibiting AD through PI3K/Akt/GSK3β/Nrf2/HO-1pathway.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway

et al. 2022

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“…Also, the prominent bands at 2913-2970 cm -1 (O-H stretch (indicating Hydroxyl or carboxyl groups) or C-H tensile vibrations), 1617.7 cm -1 (C=C stretch), 1461-1209 cm -1 (S=O stretch), 1128.9-1069.4 cm -1 (C-O stretch), 682.8-990.2 cm -1 (C=C bending), and 471.4-583.9 cm -1 were observed in the gum extract. Saeidy et al [26] The FTIR spectra of the leaf extract showed a broad and strong spectrum at 3394.9 cm -1 which indicated the O-H stretch and the presence of large amounts of hydroxyl group compounds in the extract. Also, prominent peaks at 2926.4 cm -1 (C-H tensile vibrations), 1622.9 cm -1 (C=C stretch), 1412.8-1262.2 cm -1 (S=O stretch), 1068.5-1049.7 cm -1 (C-O stretch), 665.6-555.3 cm -1 (C=C bending), and 471.4-583.9 cm -1 were observed in the leaf extract.…”

Section: Ftir As Shown In Figurementioning

confidence: 99%

“…Thermal Properties. To evaluate the thermal degradation and the mass reduction of the films and extracts as a function of temperature, thermogravimetric analysis (TGA) was performed according to ASTM E1131-14 and Saeidy et al [26] method with a slight modification using TGA apparatus (Mettler Toledo, Model TGA, Swiss). The samples heated in the range of 5-600°C with a rate of 10°C/min under nitrogen atmosphere.…”

Section: Water Vapor Transmission Rate (Wvtr)mentioning

confidence: 99%

Low-Density Polyethylene Films Carrying ferula asafoetida Extract for Active Food Packaging: Thermal, Mechanical, Optical, Barrier, and Antifungal Properties

Niazmand¹,

Razavizadeh²,

Sabbagh

2020

Advances in Polymer Technology

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The physical, thermal, mechanical, optical, microstructural, and barrier properties of low-density polyethylene films (LDPE) containing ferula asafoetida leaf and gum extracts were investigated. Results showed a reduction in elasticity and tensile strength with increasing extract concentration in the polymer matrix. The melting temperature and enthalpy increased with increasing concentration of extracts. The films containing extracts had lower L∗ and a∗ and higher b∗ indices. The films containing leaf extract had more barrier potential to UV than the gum extracts. The oxygen permeability in films containing 5% of leaf and gum extracts increased by 2.3 and 2.1 times, respectively. The morphology of the active films was similar to bubble swollen islands, which was more pronounced at higher concentrations of gum and leaf extracts. FTIR results confirmed some chemical interactions of ferula extracts with the polymer matrix. At the end of day 14th, the growth rate of Aspergillus niger and Saccharomyces cerevisea in the presence of the PE-Gum-5 reduced more than PE-Leaf-5 (3.7 and 2.4 logarithmic cycles, respectively) compared to the first day. Our findings showed that active LDPE films have desire thermo-mechanical and barrier properties for food packaging.

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“…Nowadays, scientists prefer herbal remedies in many cases. Ferula assa-foetida is one of the plants belonging to the Apiaceae family [16,17]. This plant is under cultivation in different parts of the world, including the central and southern regions of Iran, and has been used in different countries [18].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of the Essential Oil Obtained from the Seed and Oleo-Gum-Resin of Ferula assa-foetida Against Oral Pathogens

Daneshkazemi

Zandi

Davari

et al. 2019

fid

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Objectives: The objective of this study was to evaluate the antimicrobial activity of the essential oil obtained from oleo-gum-resin and seeds of Ferula assa-foetida. Materials and Methods: Ferula assa-foetida plants were collected from Tabas, Yazd Province, Iran, during summer 2017. Then, essential oils were obtained from its seeds and oleo-gum-resin using hydrodistillation. Gas chromatography-mass spectrometry (GC-MS) test was performed to determine the contents of the essential oils. Four different concentrations of each oil were prepared (2.5, 5, 10, and 20 μg/ml), and the antimicrobial activity of each dose against four oral bacteria (Streptococcus mutans, Streptococcus sobrinus, Streptococcus sanguis, Streptococcus salivarius, and Lactobacillus rhamnosus) was evaluated using the disk diffusion method. The data were analyzed using analysis of variance (ANOVA) and Kruskal-Wallis test in SPSS 17 software. Results: The GC-MS findings exhibited that the main compounds found in essential oils yielded from the seeds and oleo gum resin were (Z) -1-propenyl sec-butyl disulfide and (E) -1-propenyl sec-butyl disulfide. Ferula assa-foetida plant showed a significant antimicrobial effect (P<0.05). The essential oil from Ferula assa-foetida oleo-gum-resin had significantly stronger antibacterial properties compared to the essential oil from Ferula assa-foetida seeds (P<0.001). Both essential oils showed antibacterial properties similar to that of Chlorhexidine. The growth inhibition zone was significantly dependent on the essential oil concentration for all bacteria (P<0.05). Conclusion: Our study revealed that essential oils from seeds and oleo-gum-resin of Ferula assa-foetida have antimicrobial properties. More laboratory studies are required to reach a definitive conclusion.

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Structural characterization and thermal behavior of a gum extracted from Ferula assa foetida L.

Cited by 33 publications

References 37 publications

Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway

Asafoetida exerts neuroprotective effect on oxidative stress induced apoptosis through PI3K/Akt/GSK3β/Nrf2/HO-1 pathway

Low-Density Polyethylene Films Carrying ferula asafoetida Extract for Active Food Packaging: Thermal, Mechanical, Optical, Barrier, and Antifungal Properties

Antimicrobial Activity of the Essential Oil Obtained from the Seed and Oleo-Gum-Resin of Ferula assa-foetida Against Oral Pathogens

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