Structural characterization and physicochemical properties of quercetin–Pb complex

Ravichandran, R.; Rajendran, M.; Devapiriam, D.

doi:10.1080/00958972.2014.915317

Cited by 18 publications

(13 citation statements)

References 35 publications

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“…Additional studies are required to explore the therapeutic potential and application of other quercetin complexes. However, when quercetin is combined with some metal ions, such as lead [71] and terbium [72], its free radical scavenging and total antioxidant activity are reduced.…”

Section: Chemical Studies On the Antioxidant Activity Of Quercetinmentioning

confidence: 99%

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

et al. 2019

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Quercetin is a bioactive compound that is widely used in botanical medicine and traditional Chinese medicine due to its potent antioxidant activity. In recent years, antioxidant activities of quercetin have been studied extensively, including its effects on glutathione (GSH), enzymatic activity, signal transduction pathways, and reactive oxygen species (ROS) caused by environmental and toxicological factors. Chemical studies on quercetin have mainly focused on the antioxidant activity of its metal ion complexes and complex ions. In this review, we highlight the recent advances in the antioxidant activities, chemical research, and medicinal application of quercetin.

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Section: Chemical Studies On the Antioxidant Activity Of Quercetinmentioning

confidence: 99%

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

et al. 2019

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“…One of the lesser investigated properties of these compounds is the ability to bind metals, most likely through the structural hydroxyl moieties ( Figure 1 ). Reports in the literature have shown that genistein is capable of binding copper and iron [ 12 , 13 ], quercetin can chelate copper and lead [ 14 , 15 ], curcumin can bind cadmium and lead [ 16 ], and lentinan can chelate cadmium [ 17 ]. Despite these findings, there have been no reports on the ability of these compounds to bind those metals that are of concern with respect to internal contamination, namely, cesium, strontium, uranium, and cobalt.…”

Section: Introductionmentioning

confidence: 99%

Nutraceuticals as Potential Radionuclide Decorporation Agents

Vergara

Kalinich

2021

Nutrients

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Exposure of individuals to radioactive material as a result of ingestion of contaminated food and water is an increasing public health concern. Unfortunately, there are limited treatment modalities for dealing with these types of potentially toxic exposures. Recent research suggests that many plant-based nutraceuticals may possess metal-binding properties. This preliminary study investigated the ability of genistein, curcumin, quercetin, and lentinan to bind metals considered internal contamination risks, namely cesium, uranium, cobalt, and strontium, in a variety of matrices. The efficacy of these nutraceuticals in protecting cultured cells from metal-induced toxicity was also explored. Results showed that none of the compounds bound cesium or strontium. However, genistein, curcumin, and quercetin could bind uranium. Curcumin and quercetin also bound cobalt and could also protect cultured cells from metal-induced cytotoxicity. Lentinan did not bind any of the metals tested. Metal binding was also pH dependent, with no binding observed at lower pH values. This project showed that nutraceuticals could function as chelators for metals considered internal radionuclide contamination hazards. Further investigations are required in order to determine whether these compounds will become a new nontoxic arsenal of pharmaceutical compounds with which to treat radionuclide contamination.

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“…Aktivitas antiradikal pada kuersetin dipengaruhi juga oleh adanya gugus hidroksil yang terikat pada C4'. Efektivitas kuersetin dalam menangkap radikal bebas meningkat dengan adanya gugus orto-hidroksi pada cincin B [15]. Struktur kimia kuersetin dapat dilihat pada Gambar 1.…”

Section: Pendahuluanunclassified

Karakteristik Fisikokimia Senyawa Kuersetin Bertanda Radioaktif Iodium-131

Sriyani

Widyasari

Febriyanti

et al. 2020

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KARAKTERISTIK FISIKOKIMIA SENYAWA KUERSETIN BERTANDA RADIOAKTIF IODIUM-131. Penggunaan bahan-bahan herbal (obat tradisional) untuk pengobatan penyakit-penyakit kronis semakin banyak dikonsumsi. Fenomena ini mendorong perkembangan penelitian dan penemuan obat baru berbasis bahan alam melalui proses isolasi maupun sintesis. Salah satu tahapan pengembangan obat dalam penentuan efikasi adalah pemanfaatan teknologi nuklir pada tahap uji preklinis baik secara in-vitro maupun in-vivo. Pada tahap awal penelitian, telah dilakukan pemilihan bahan aktif berkhasiat antikanker dan penelaahan kemungkinan senyawa tersebut untuk ditandai menggunakan radioisotop pemancar beta (β-). Penelaahan meliputi struktur kimia bahan aktif tersebut (kemungkinan ikatan yang mungkin terjadi antara senyawa aktif dengan radioisotop pemancar beta), serta teknik penandaan yang akan dilakukan. Metode penandaan Kuersetin dengan radioisotop iodium-131 menggunakan oksidator Kloramin-T mengacu pada penelitian yang telah dilakukan oleh Barolli, dkk dengan sedikit modifikasi. Tujuan penelitian ini adalah untuk menentukan sifat fisikokimia senyawa bertanda 131I-kuersetin meliputi kemurnian radiokimia, muatan listrik senyawa 131I-Kuersetin, lipofilisitas (log P), ikatan dengan protein plasma dan stabilitas sediaan. Hasil yang didapat adalah senyawa 131I-Kuersetin dengan kemurnian radiokimia sebesar 98,41 ± 1,05 %, memiliki muatan listrik negatif dan nilai koefisien partisi (log P) sebesar -2,22 di dalam Larutan NaCl dan -2,71 di dalam larutan dapar fosfat. Persentase ikatan dengan protein plasma sebesar 34,64±4,37 % pada larutan NaCl dan 32,94±1,46 % pada larutan dapar fosfat. Hasil pengujian variasi volume sediaan 131I-kuersetin, volume diatas 1 mL akan menurunkan kemurnian radiokimianya menjadi < 90 %. Sedangkan dari pengujian stabilitas sediaan 131I-kuersetin tetap stabil hingga jam ke-72, pada suhu kamar dengan hasil kemurnian radiokimia yang tinggi ≥ 95%.

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Structural characterization and physicochemical properties of quercetin–Pb complex

Cited by 18 publications

References 35 publications

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

Nutraceuticals as Potential Radionuclide Decorporation Agents

Karakteristik Fisikokimia Senyawa Kuersetin Bertanda Radioaktif Iodium-131

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