Structural characterization and in vitro antitumor activity of a novel polysaccharide isolated from the fruiting bodies of Pleurotus ostreatus

Antibacterial and cytotoxic activity from basidiocarp extracts of the edible mushroom Lactarius indigo (Schw.) Fr. (Russulaceae)

“…One possibility is that the aqueous extract of L. indigo contains active polysaccharides that are specific against cancer cell lines. One polysaccharide has been isolated from the aqueous extract of Pleuotus ostreatus that has an antiproliferative effect against HeLa cells at concentrations of 100, 200 and 400 µM, but that has no significant inhibitory effect on normal human embryonic kidney cells 293T (Tong et al, 2009). Recently, a polysaccharide enriched with selenium was obtained from an aqueous extract of vegetative mycelium of Ganoderma lucidum that displays a high antiproliferative activity in vitro against HeLa and MCF7 cells with IC 50 values of 0.17 and 0.14 µM, respectively (Shang et al, 2009).…”

Effect of Seed Disinfection on Bakanae disease in Ginkgo biloba Outer Seed Coat Extract

“…This type of polysaccharide has glucose, rhamnose and mannose; or mannose, glucose and galactose linkages. It is known that the polysaccharide extracted from mushrooms has anti-cancer activity for various cancer cells (Tong et al, 2009;Yang et al, 2005). Zhu et al (2012) reported that polysaccharide separated from mushrooms has antibacterial activity against certain types of bacteria.…”

Untitled

“…In a dose dependent in vitro study on HeLa tumor cell , POP-1showed significant higher anti-tumor activity against HeLa tumor cell and lower cytotoxicity to human embryo kidney 293T cells than anticancer drug 5-fluorouracil. The results suggest POPS-1 may be taken into account as a potential remedy for developing a novel low-toxicity anti-tumor agent 18 . Lectin a homodimeric 32.4 kDa extracted from fresh fruiting bodies of the mushroom Pleurotus citrinopileatus showed potent anti-tumor activity in mice bearing sarcoma 180.When extract administered intraperitoneally at 5 mg/kg daily for 20 days,and inhibited tumor enlargement to agreat extent (approximately 80%) 19 .…”