Structural characterization and DFT study of bis{(S)-2-[(2-hydroxybenzyl)amino]-3-(4-hydroxyphenyl)propanoato-κ2
 N,O}(1,10-phenanthroline-κ2
 N,N′)cadmium(II) tetrahydrate

Faizi, Md. Serajul Haque; Dege, Necmi; Pogrebetsky, James; Iskenderov, Turganbay S.

doi:10.1107/s205698901801157x

Cited by 3 publications

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References 17 publications

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“…[CoLH] + demonstrated a lower related stability constant value than the completely deprotonated [CoL], indicating the formation of one five-membered chelate ring as a result of bidentate {N,O − carboxyl } coordination ( Table 1 ). Moreover, this type of coordination is supported by X-ray data for the crystal forms of hydroxybenzyl derivative complexes in which the phenolic −OH group participates in an intramolecular NH … O hydrogen bond [ 44 , 45 ]. In addition, the same {N amine ,O − carboxyl } chelation mode is suggested for protonated histidine complex, showing a value of related stability constant (2.32) of the same order as [CoLH] + [ 38 , 46 ].…”

Section: Resultsmentioning

confidence: 96%

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

et al. 2020

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The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)alanine, towards cobalt(II) using potentiometric as well as spectroscopic (UV-Vis and ESI-MS) methods. The results indicate the formation of six mononuclear complexes showing high stability in aqueous solution. Coordination occurs in the {O−phenolic,N,O−carboxyl} and {N,O−carboxyl} chelation modes, depending on the degree of ligand deprotonation. Examination of the complexation equilibria at pH ca 7, which is important from a biological point of view, allowed to identify two species: [CoL] and [CoL2H]−. The kinetic analysis showed a structural change of those cobalt(II) complexes from octahedral to tetrahedral in accordance with a first-order time relationship. The antimicrobial properties of N-(2-hydroxybenzyl)alanine, cobalt(II) nitrate and of the Co(II) – ligand complexes were determined against Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis), Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Helicobacter pylori) and a fungal strain (Candida). The results indicate that the complexes are more active for more strains than the ligand alone. Nevertheless, the complexes induce a higher decrease in the metabolic activity of cells but without damage to nuclei. Tetrahedral structures show stronger anti-cellular toxicity than octahedral complexes, which is most likely due to the higher accessibility of the cobalt(II) center.

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Section: Resultsmentioning

confidence: 96%

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

et al. 2020

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Equilibria of complexes in the aqueous cobalt(II)–N-(2-hydroxybenzyl)phenylalanine system and their biological activity compared to analogous Schiff base structures

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Świątek

Sutradhar

et al. 2023

Computational and Structural Biotechnology Journal

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Synthesis, physicochemical properties, and antitumor cytotoxic activity of the Mg(II) coordination complex containing 1,10-phenanthroline and sulfate ligands

Neto

Viana

Butarelli

et al. 2023

Inorganica Chimica Acta

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Structural characterization and DFT study of bis{(S)-2-[(2-hydroxybenzyl)amino]-3-(4-hydroxyphenyl)propanoato-κ² N,O}(1,10-phenanthroline-κ² N,N′)cadmium(II) tetrahydrate

Abstract: In the crystal, the CdII atom, located on a twofold rotation axis, is coordinated by three chelating ligands, leading to a distorted octahedral CdN4O2 coordination sphere.

Cited by 3 publications

References 17 publications

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

Equilibria of complexes in the aqueous cobalt(II)–N-(2-hydroxybenzyl)phenylalanine system and their biological activity compared to analogous Schiff base structures

Synthesis, physicochemical properties, and antitumor cytotoxic activity of the Mg(II) coordination complex containing 1,10-phenanthroline and sulfate ligands

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Structural characterization and DFT study of bis{(S)-2-[(2-hydroxybenzyl)amino]-3-(4-hydroxyphenyl)propanoato-κ2 N,O}(1,10-phenanthroline-κ2 N,N′)cadmium(II) tetrahydrate

Abstract: In the crystal, the CdII atom, located on a twofold rotation axis, is coordinated by three chelating ligands, leading to a distorted octa­hedral CdN4O2 coordination sphere.

Cited by 3 publications

References 17 publications

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties

Equilibria of complexes in the aqueous cobalt(II)–N-(2-hydroxybenzyl)phenylalanine system and their biological activity compared to analogous Schiff base structures

Synthesis, physicochemical properties, and antitumor cytotoxic activity of the Mg(II) coordination complex containing 1,10-phenanthroline and sulfate ligands

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Structural characterization and DFT study of bis{(S)-2-[(2-hydroxybenzyl)amino]-3-(4-hydroxyphenyl)propanoato-κ² N,O}(1,10-phenanthroline-κ² N,N′)cadmium(II) tetrahydrate

Abstract: In the crystal, the CdII atom, located on a twofold rotation axis, is coordinated by three chelating ligands, leading to a distorted octahedral CdN4O2 coordination sphere.