Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings

Iconaru, Simona Liliana; Продан, А. М.; Buton, Nicolas; Predoi, Daniela

doi:10.3390/molecules22040604

Cited by 56 publications

(46 citation statements)

References 35 publications

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“…The value of the average electrophoretic mobility was −0.00034 cm 2 V −1 s −1 ( Figure 2C). The value obtained for the ζ-potential in the ZnHAp gel was much higher than which has been reported so far [19,31]. This difference may be due to increasing the zinc concentration, and, on the other hand, to the synthesis parameters.…”

Section: Characterization Of Suspensioncontrasting

confidence: 58%

Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure

et al. 2019

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In this study, ZnHAp layers deposited on a Si substrate were obtained by a sol–gel spin-coating procedure. The ZnHAp solutions used to obtain the ZnHAp coatings were investigated by dynamic light scattering (DLS) analysis, ζ-potential, ultrasound measurements, and flame atomic absorption spectrometry (AAS). The average measured hydrodynamic diameter from the DLS analysis, ζ-potential, and ultrasound measurements were analyzed so as to characterize and estimate the stability of the ZnHAp nanoparticles. The AAS results confirmed the presence of zinc in the gels used in the preparation of the ZnHAp layers. The layers were investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The XRD results revealed the diffraction peaks of the hexagonal hydroxyapatite in all of the investigated samples. The morphology of the ZnHAp coatings annealed at 500 °C (ZnHAp-500) and 700 °C (ZnHAp-700), which evidenced that no fissures or cracks formed on the surface of the coatings. The biocompatibility assays indicated that the ZnHAp coatings did not present any toxicity towards the HeLa cells. Furthermore, the study regarding the cytotoxicity of the ZnHAp layers against microorganisms emphasized that ZnHAp coatings exhibited an inhibitory effect towards S. aureus bacterial cells and also towards C. albicans fungal cells.

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Section: Characterization Of Suspensioncontrasting

confidence: 58%

Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure

et al. 2019

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“…A Duncan’s test confirmed that the influence of nano-ZnO on antimicrobial properties of (K) PE films ( p < 0.001) or PE films covered with MHPC ( p < 0.001) was significant. It was shown [ 21 ] that zinc is effective in inhibiting the growth of C . albicans .…”

Section: Resultsmentioning

confidence: 99%

The Influence of Accelerated UV-A and Q-SUN Irradiation on the Antimicrobial Properties of Coatings Containing ZnO Nanoparticles

et al. 2017

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The influence of accelerated UV-A and Q-SUN irradiation on the antimicrobial properties of coatings containing ZnO nanoparticles was investigated using a polyethylene (PE) film covering. The results of the study showed that Methyl Hydroxypropyl Celluloses (MHPC) coatings did not influence the growth of S. aureus, B. cereus, E. coli, P. aeruginosa or C. albicans cells. MHPC coatings containing ZnO nanoparticles inhibited the growth of bacterial strains and reduced the number of C. albicans strains. Accelerated Q-SUN and UV-A irradiation had no influence on the antimicrobial effect of nano ZnO coatings against S. aureus, B. cereus and E. coli. Q-SUN irradiation decreased the activity of MHPC coatings containing nanoparticles against P. aeruginosa and C. albicans. An FT-IR analysis clearly showed that ZnO nanoparticles shielded the MHPC coating during Q-SUN irradiation.

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“…The coating process was carried out at a speed of 2000 rpm by centrifugation for 60 s. Next, the pure Ti disks coated with a composite layers (Ag:HAp-S1 and Ag:HAp-S2 ) were dried for 60 min at 100 • C. Spin-coating and dried procedures were repeated 3 times. Finally, the Ag:HAp-S1 and Ag:HAp-S2 composite layers were thermally treated for 12 h at 300 • C (with heating rate of 1 • C/min) in order to obtain films with a crystalline structure and to remove the solvents [58]. On the other hand, the resulted sol-gel solutions, S1 (mixture stirred a week at 40 • C) and S2 (mixture stirred a week at 80 • C) used to prepare the Ag:HAp-S1 and Ag:HAp-S2 composite layers by spin-coating technique were analyzed for the first time by ultrasonic measurements in order to highlight the stability of these solutions.…”

Section: Layers Of Silver Doped Hydroxyapatite Preparationmentioning

confidence: 99%

Bioceramic Layers with Antifungal Properties

2018

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The sol-gel method was used to synthesize the silver doped hydroxyapatite (Ag:HAp) gels in order to produce the antifungal composite layers. The pure Ti disks were used as the substrate for the composite layers. Important information about suspensions used to make Ag:HAp composite layers were obtained from an ultrasonic technique. The identification of the phase composition of the Ag:HAp composite layers was accomplished X-ray diffraction (XRD). The morphology and the thickness of the layers was evaluated using scanning electron microscopy (SEM). The uniform distribution of the constituent elements (Ag, Ca, P, and O) in both analyzed samples was observed. The antifungal activity of the samples against Candida albicans ATCC 10231 microbial strain were investigated immediately after their preparation and six months later. SEM and confocal laser scanning microscopy (CLSM) images showed that the composite layers at the two time intervals exhibited a strong antifungal activity against Candida albicans ATCC 10231 and completely inhibited the biofilm formation.

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Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings

Cited by 56 publications

References 35 publications

Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure

Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure

The Influence of Accelerated UV-A and Q-SUN Irradiation on the Antimicrobial Properties of Coatings Containing ZnO Nanoparticles

Bioceramic Layers with Antifungal Properties

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