Structural, biocomplexation and gene delivery properties of hydroxyethylated gemini surfactants with varied spacer length

Zakharova, L. Ya.; Gabdrakhmanov, Dinar R.; Ibragimova, A. R.; Vasilieva, Elmira A.; Nizameev, Irek R.; Kadirov, Marsil K.; Ермакова, Елена; Gogoleva, Natalia; Faizullin, Dzhigangir A.; Pokrovsky, Andrey G.; Korobeynikov, Vladislav A.; Чересиз, С. В.; Zuev, Yu. F.

doi:10.1016/j.colsurfb.2015.12.045

Cited by 31 publications

(26 citation statements)

References 79 publications

(89 reference statements)

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“…Some gemini surfactants with sugar substituent, peptide moiety [225,226] or cholesterol-based diquaternary ammonium gemini surfactant [227] were tested as a gene transfection vectors. It was recently shown that hydroxyethylated gemini surfactants [228], fluorinated bispyridinium gemini surfactants [229] and geminis derived from cysteine [230,231] can be also used for this application.…”

Section: Gene Therapy and Bioimagingmentioning

confidence: 99%

Multifunctional Gemini Surfactants: Structure, Synthesis, Properties and Applications

Brycki¹,

Kowalczyk²,

Szulc³

et al. 2017

Application and Characterization of Surfactants

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Gemini cationic surfactants are compounds which are composed of two hydrophilic head groups and two hydrophobic tails linked by a spacer at the head groups or closed to them. The spacer can be either hydrophobic or hydrophilic. It can be rigid or flexible. The neutral charge of the molecule is retained by the presence of organic or inorganic counterions. Critical micelle concentrations (CMCs), surface tension (γ) and minimal inhibitory concentration (MIC) are dozen times lower than corresponding parameters of monomeric surfactants. The unique properties of gemini surfactants with a wide range of hydrophiliclipophilic balance (HLB) make them a very useful, innovative material in detergents, cosmetics, personal care products, additives for paints and coatings, biocides, material science, organic synthesis, pharmacy, textiles, enhanced oil recovery, nanotechnology, petroleum and many other branches of life. A large number of papers concerning gemini surfactants have been published so far. This review presents a synthetic look at current work devoted to structure, synthesis and applications of gemini surfactants.

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Section: Gene Therapy and Bioimagingmentioning

confidence: 99%

Multifunctional Gemini Surfactants: Structure, Synthesis, Properties and Applications

Brycki¹,

Kowalczyk²,

Szulc³

et al. 2017

Application and Characterization of Surfactants

View full text Add to dashboard Cite

show abstract

“…Giron-Gonzalez et al [ 7 ] showed that complexes containing polyethyleneimine (PEI) and citric acid (CA) transfected the several cell lines with higher efficiency than Lipofectamine or PEI and also promoted in vivo transfection in mouse with an enhanced efficiency compared to PEI. Zakharova et al [ 8 ] tested hydroxyethylated gemini surfactants with varied spacer length/pGFP (plasmid DNA encoding for green fluorescent protein) complexes and showed that transfection of eukaryotic cells with use of some of the formulations resulted in considerably high transfection efficiency (about 50–75% of GFP-positive cells). Parvizi et al [ 9 ] showed that lipoplex formulations based on cationic pyridinium-based lipids co-formulated with the cationic lipid 1,2-dimyristoyl-sn-glycero-3-ethylphosphocholine (EPC) and cholesterol transfected cells with efficiency similar to obtained with use of Lipofectamine2000.…”

Section: Introductionmentioning

confidence: 99%

Prenyl Ammonium Salts – New Carriers for Gene Delivery: A B16-F10 Mouse Melanoma Model

et al. 2016

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PurposePrenyl ammonium iodides (Amino-Prenols, APs), semi-synthetic polyprenol derivatives were studied as prospective novel gene transfer agents.MethodsAP-7, -8, -11 and -15 (aminoprenols composed of 7, 8, 11 or 15 isoprene units, respectively) were examined for their capacity to form complexes with pDNA, for cytotoxicity and ability to transfect genes to cells.ResultsAll the carriers were able to complex DNA. The highest, comparable to commercial reagents, transfection efficiency was observed for AP-15. Simultaneously, AP-15 exhibited the lowest negative impact on cell viability and proliferation—considerably lower than that of commercial agents. AP-15/DOPE complexes were also efficient to introduce pDNA to cells, without much effect on cell viability. Transfection with AP-15/DOPE complexes influenced the expression of a very few among 44 tested genes involved in cellular lipid metabolism. Furthermore, complexes containing AP-15 and therapeutic plasmid, encoding the TIMP metallopeptidase inhibitor 2 (TIMP2), introduced the TIMP2 gene with high efficiency to B16-F10 melanoma cells but not to B16-F10 melanoma tumors in C57BL/6 mice, as confirmed by TIMP2 protein level determination.ConclusionObtained results indicate that APs have a potential as non-viral vectors for cell transfection.

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“…Due to their excellent properties, gemini surfactants can have many potential industrial applications such as cleaning agents and detergents, biocides, preservatives and solubilisation agents in textile dying [7,[9][10][11][12][13][14]. They can be also applied in nanotechnology as gene delivery agents and supramolecular solvents [15][16][17]. Recently, greater attention has been paid to the use of gemini surfactants as corrosion inhibitors (CIs) for metals, especially in acidic environments [18][19][20][21][22][23][24].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Efficiency of cationic gemini surfactants with 3-azamethylpentamethylene spacer as corrosion inhibitors for stainless steel in hydrochloric acid

Kaczerewska

Leiva-García

Akid

et al. 2017

Journal of Molecular Liquids

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Structural, biocomplexation and gene delivery properties of hydroxyethylated gemini surfactants with varied spacer length

Cited by 31 publications

References 79 publications

Multifunctional Gemini Surfactants: Structure, Synthesis, Properties and Applications

Multifunctional Gemini Surfactants: Structure, Synthesis, Properties and Applications

Prenyl Ammonium Salts – New Carriers for Gene Delivery: A B16-F10 Mouse Melanoma Model

Efficiency of cationic gemini surfactants with 3-azamethylpentamethylene spacer as corrosion inhibitors for stainless steel in hydrochloric acid

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