Structural/audiometric correlations in a human inner ear with noise-induced hearing loss

Rask‐Andersen, Helge; Ekvall, Lars; Scholtz, Arne W.; Schrott‐Fischer, Anneliese

doi:10.1016/s0378-5955(99)00216-6

Cited by 34 publications

(18 citation statements)

References 23 publications

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“…These sounds can be measured in the ear canal with a low-noise microphone. OAEs are thought to be generated by the outer hair cells ͑OHCs͒, which are susceptible to noise damage ͑e.g., Liberman et al, 1986;Nordmann et al, 2000;Rask-Andersen et al, 2000͒. Diminished OAE amplitudes may be an early warning sign of incipient noiseinduced hearing loss ͑NIHL͒, and therefore they may have a role to play in hearing-conservation programs.…”

Section: Introductionmentioning

confidence: 99%

Low-level otoacoustic emissions may predict susceptibility to noise-induced hearing loss

Miller

Marshall

Heller

et al. 2006

The Journal of the Acoustical Society of America

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In a longitudinal study with 338 volunteers, audiometric thresholds and otoacoustic emissions were measured before and after 6 months of noise exposure on an aircraft carrier. While the average amplitudes of the otoacoustic emissions decreased significantly, the average audiometric thresholds did not change. Furthermore, there were no significant correlations between changes in audiometric thresholds and changes in otoacoustic emissions. Changes in transient-evoked otoacoustic emissions and distortion-product otoacoustic emissions were moderately correlated. Eighteen ears acquired permanent audiometric threshold shifts. Only one-third of those ears showed significant otoacoustic emission shifts that mirrored their permanent threshold shifts. A Bayesian analysis indicated that permanent threshold shift status following a deployment was predicted by baseline low-level or absent otoacoustic emissions. The best predictor was transient-evoked otoacoustic emission amplitude in the 4-kHz half-octave frequency band, with risk increasing more than sixfold from approximately 3% to 20% as the emission amplitude decreased. It is possible that the otoacoustic emissions indicated noise-induced changes in the inner ear, undetected by audiometric tests. Otoacoustic emissions may therefore be a diagnostic predictor for noise-induced-hearing-loss risk.

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Section: Introductionmentioning

confidence: 99%

Low-level otoacoustic emissions may predict susceptibility to noise-induced hearing loss

Miller

Marshall

Heller

et al. 2006

The Journal of the Acoustical Society of America

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“…This adds insights into the surface structure of the modiolar wall and its relation to the spiral ganglion. We previously published results from transmission electron microscopy (TEM) studies of the human spiral ganglion using surgically obtained tissue , 2000aTylstedt et al, 1997;Tylstedt and RaskAndersen, 2001] and on the organ of Corti using SEM [Glueckert et al, 2005]. This represents the fi rst such study to detail the morphology and characteristics of the human spiral ganglion using SEM and sectioned material.…”

Section: Introductionmentioning

confidence: 99%

The Human Spiral Ganglion: New Insights into Ultrastructure, Survival Rate and Implications for Cochlear Implants

Glueckert¹,

Pfaller

Kinnefors

et al. 2005

Audiol Neurotol

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This study was based on high-resolution SEM assessment of freshly fixed, normal-hearing, human inner ear tissue. In addition, semiquantitative observations were made in long-term deafened temporal bone material, focusing on the spiral ganglia and nerve projections, and a detailed study of the fine bone structure in macerated tissues was performed. Our main findings detail the presence of extensive bony fenestrae surrounding the nerve elements, permitting a relatively free flow of perilymph to modiolar structures. The clustering of the spiral ganglion cells in Rosenthal’s canal and the detailed and intricate course of postganglionic axons are described. The close proximity of fibers to cell soma is demonstrated by impression in cell surfaces, and presence of small microvilli-like structures at the contact regions, anchoring nerve fibers to the cell wall. Extensive fenestrae and the presence of a fragile network of endosteal bony structures at the surfaces guiding nerve fibers are described in detail for the first time. This unique freshly prepared human material offers the opportunity for a detailed ultrastructural study not previously possible on postmortem fixed material and more accurate information to model electrostimulation of the human auditory nerve through a cochlear implant. On the basis of this study, we suggest that the concentration and high density of spiral ganglion cells, and the close physical interaction between neural elements, may explain the slow retrograde degeneration found in humans after loss of peripheral receptors. Moreover, the fragile bony columns connecting the spiral canal with the osseous spiral lamina may be a potential site for trauma in (perimodiolar) electrode positioning.

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“…Nach einer Lärmbelastung von 86 dB über einen Zeitraum von 24 Stunden mit temporärem Hörverlust wurde tierexperimentell als Korrelat ein entsprechender Höhenverlust der Pfeilerzellen beobachtet[20]. In einer im Rahmen eines Schädel-basiseingriffs entfernten Kochlea fand sich bei der Anamnese einer 30-jährigen Lärmbelastung bei einem Patienten ein Kollaps der äußeren Pfeilerzelle[21]. In dem Bemühen um eine Protektion vor lärmbedingten Innenohrschädigungen sind vielfältige Ansätze Gegenstand derzeitiger Forschungsbemühungen.…”

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Temporäre sensorineurale Hörverluste nach Ohroperationen - eine retrospektive Analyse

Schick

Kochannek

et al. 2007

Laryngorhinootologie

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Structural/audiometric correlations in a human inner ear with noise-induced hearing loss

Cited by 34 publications

References 23 publications

Low-level otoacoustic emissions may predict susceptibility to noise-induced hearing loss

Low-level otoacoustic emissions may predict susceptibility to noise-induced hearing loss

The Human Spiral Ganglion: New Insights into Ultrastructure, Survival Rate and Implications for Cochlear Implants

Temporäre sensorineurale Hörverluste nach Ohroperationen - eine retrospektive Analyse

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