Structural and phase analysis of multi-ion doped hydroxyapatite for biomedical applications

Reger, N.; Bhargava, Anil K.; Ratha, Itishree; Kundu, Biswanath; Balla, Vamsi Krishna

doi:10.1016/j.ceramint.2018.09.160

Cited by 43 publications

(22 citation statements)

References 34 publications

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“…The potential reasons for relatively high ion release due to doping would be (a) changes in the crystallinity and crystallite size and (b) lattice strain or distortion that occurs due to replacement of these cations with dopants namely Sr +2 , Zn +2 , and Ag + . The changes in the crystallinity and crystallite size of present compositions have been reported in our earlier study. Further the extent of lattice stain depends on the ionic radii difference between Ca +2 and dopants.…”

Section: Resultssupporting

confidence: 81%

“…Highest density of ~3.1 g/cc (~98%) can be achieved with 5 wt% F doping. The high sintered density along with multi‐ion doping of HA found to increase the hardness of HA from 3.7 GPa to a range between 3.8 and 6.0 GPa . Here again Sr and F doping significantly increased the hardness of sintered HA.…”

Section: Resultsmentioning

confidence: 85%

“…However, studies related to ternary and quaternary doping of HA appears to be extremely rare. In our earlier study we have analyzed the influence of multi‐ion doping (Sr +2 , Zn +2 , Ag + , and F − ) on the crystallinity, crystal size, and hardness of HA and confirmed the doping. In the present work an attempt has been made to assess the in vitro cytotoxicity, bioactivity and ion release of these multi‐ion doped HA.…”

Section: Introductionmentioning

confidence: 75%

“…From cell proliferation point of view also these compositions ensured long‐term cytocompatibility as discussed above. Furthermore, the nominal crystallinity and small crystallite size of these HA compositions also would have contributed to their excellent cell proliferation.…”

Section: Resultsmentioning

confidence: 99%

“…The HA powder with and without dopants was finally calcined at 1250°C in an electrical resistance furnace for 2 hours. The crystallinity, crystal size, and confirmation of ion doping have been done in our earlier study . The HA powder, with and without dopants, was pressed (∅ 12 mm, 2 mm thick) and sintered at 1250°C for 2 hours with heating and cooling rate of 5°C/min.…”

Section: Methodsmentioning

confidence: 99%

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In vitro cytotoxicity and ion release of multi‐ion doped hydroxyapatite

Reger

Kundu

Balla

et al. 2018

Int J Applied Ceramic Tech

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Multi-ion doped hydroxyapatite (HA) is gaining more attention due to its potential in enhancing multifunctional biological, structural, and mechanical properties for orthopedic and dental applications. In this study, HA doped with multiple cations (Sr +2 , Zn +2 , Ag + ) and anion (F − ) was prepared by high-energy ball milling. Sintered HA samples were evaluated for their in vitro cytocompatibility, ion release, and bioactivity. The composition of multi-ion doped HA was optimized usingDesign of experiments (DOE). Our analysis showed that the contribution of each dopant on cell proliferation changes with culture duration. During first 3 days, F − exhibited strongest influence and during 7-day proliferation Sr +2 and Ag + had maximum influence. Binary ion doping found to have strong interaction on cell proliferation, while the ternary and quaternary ion doping did not show any interactions. In general, up to twofold increase in the cell viability was achieved with ternary and quaternary ion doping consisting of Sr +2 , Zn +2 , Ag + and F − .Although large number of compositions has been identified to exhibit better in vitro cell viability than pure HA, for enhanced long-term cytocompatibility the compositions of multi-ion doped HA would be 2.5Sr-2.5Zn-2.5Ag, 2.5Sr-5Zn-2.5Ag, and 5Sr-2.5Zn-2.5Ag with up to 5 wt% F. K E Y W O R D Sbioactivity, doped HA, in vitro, ion release, multi-ion

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 75%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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In vitro cytotoxicity and ion release of multi‐ion doped hydroxyapatite

Reger

Kundu

Balla

et al. 2018

Int J Applied Ceramic Tech

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Multi‐ion‐doped nano‐hydroxyapatite‐coated titanium intramedullary pins for long bone fracture repair in dogs—Clinical evaluation

et al. 2021

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Plasma spray nano-hydroxyapatite-coated titanium intramedullary implants doped either with 5% zinc, 2.5% strontium, and 2.5% fluorine ions or with 5% zinc, 5% strontium, and 2.5% silver ions were evaluated compared with plasma spray nano-hydroxyapatite-coated titanium intramedullary implant and uncoated titanium intramedullary implants for open reduction and internal immobilization in 24 clinical cases of long bone fracture repair in dogs. Fracture-healing limb outcome was evaluated clinically, that is, radiographically. Biochemical estimation of serum calcium, serum phosphorus, alkaline phosphatase (ALP), and bone markers (bone ALP [BALP] and C-telopeptide of type 1 collagen [CTX]) was carried out on 0th day, 3rd week, 6th, and 9th week postoperatively. Multi-ion-doped plasma spray nano-hydroxyapatite-coated titanium intramedullary implants were found to be superior to plasma spray nano-hydroxyapatite-coated titanium intramedullary implants and uncoated titanium intramedullary implants in terms of all the parameters studied. Using plasma spray nano-hydroxyapatite-coated titanium implants doped with multi ions, that is, 5% zinc, 5% strontium, and 2.5% silver gave the best results in fracture repair followed by the implants doped with 5% zinc, 2.5% strontium, and 2.5% fluorine ions. Earliest and excellent limb usage with no postoperative complications was the hallmark of the use of these multi-ion-doped implants with higher serum calcium, serum phosphorus, ALP, BALP, and CTX values up to 3rd postoperative week and no lameness on the 21st day. K E Y W O R D S coated titanium intramedullary pins, dogs, long bone fracture repair, multi-ion-doped, nanohydroxyapatite 1 | INTRODUCTION Fracture of long bones is a common orthopedic condition in dogs. The intramedullary pinning is a simple and economic method of immobilization of the diaphyseal fractures. 1 The materials used for orthopedic implants should possess excellent biocompatibility without cytotoxicity, superior corrosion resistance in the body environment, excellent combination of high strength and low modulus, high fatigue and wear resistance, and high ductility. Stainless steel, cobalt, chromium alloys, and titanium-based alloys are currently used for orthopedic implants, and these materials exhibit a tendency to fail after long-term use due to various reasons such as high modulus compared to that of bone, low wear, corrosive resistance, and lack of biocompatibility necessitating the development of appropriate materials with high longevity and excellent biocompatibility. 2 Titanium and its alloys are preferred for load-bearing orthopedic implants due to the superior corrosion resistance as well as fatigue

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La³⁺and F⁻dual‐doped multifunctional hydroxyapatite nanoparticles: Synthesis and characterization

Erdem

Turkoz

2021

Microscopy Res & Technique

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Hydroxyapatite (HA) co-doped with La 3+ and F À ions were synthesized by the precipitation method and sintered at 1,100 C for 1 hr. Samples were characterized by the standard experimental methods including the density, X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM) to investigate their microstructure, phase formation, and bonding characteristics in detail. Moreover, the materials produced were identified using the microhardness tests. It was observed that in the most of materials, the hydroxyapatite was found to be the main phase with a minor amount of β-tricalcium phosphate (β-TCP).Furthermore, the presence of fluoride and small amount of β-TCP was verified with all the characteristic FTIR bands of hydroxyapatite for the majority of samples studied. The result in SEM evaluation is that the produced HA powders have less deformed, uniformly distributed, and regularly shaped particles. Here, the material density has changed towards a less dense state with the increasing rate of La doping, but statistically significant difference was not obtained (p, .1942 > .05) with increase

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Structural and phase analysis of multi-ion doped hydroxyapatite for biomedical applications

Cited by 43 publications

References 34 publications

In vitro cytotoxicity and ion release of multi‐ion doped hydroxyapatite

In vitro cytotoxicity and ion release of multi‐ion doped hydroxyapatite

Multi‐ion‐doped nano‐hydroxyapatite‐coated titanium intramedullary pins for long bone fracture repair in dogs—Clinical evaluation

La³⁺and F⁻dual‐doped multifunctional hydroxyapatite nanoparticles: Synthesis and characterization

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Structural and phase analysis of multi-ion doped hydroxyapatite for biomedical applications

Cited by 43 publications

References 34 publications

In vitro cytotoxicity and ion release of multi‐ion doped hydroxyapatite

In vitro cytotoxicity and ion release of multi‐ion doped hydroxyapatite

Multi‐ion‐doped nano‐hydroxyapatite‐coated titanium intramedullary pins for long bone fracture repair in dogs—Clinical evaluation

La3+and F−dual‐doped multifunctional hydroxyapatite nanoparticles: Synthesis and characterization

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La³⁺and F⁻dual‐doped multifunctional hydroxyapatite nanoparticles: Synthesis and characterization