Structural and morphologic differences in human oocytes after in vitro maturation compared with standard in vitro fertilization

Walls, Melanie; Hart, Roger; Keelan, Jeffrey A.; Ryan, John P.

doi:10.1016/j.fertnstert.2016.08.014

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…By observing embryos dynamically using time-lapse videos, it was confirmed that oocytes matured in vivo or in vitro showed no significant differences in terms of the morphological dynamics observed during the early development of embryos derived from these oocytes [40]. Another study has also shown that the oocytes matured in vitro and in vivo are different in terms of their organelle function, distribution, and gene expression [41]. The different experimental conclusions mentioned above may be caused by different sources and quality of oocytes used in these studies.…”

Section: Clinical Application and Safety Of Ivmmentioning

confidence: 85%

Clinical Application of In Vitro Maturation of Oocytes

La¹,

Zhao²,

Wang³

2019

Embryology - Theory and Practice

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In vitro maturation (IVM) is a technique used to induce immature oocytes collected in different periods of embryonic growth. The rates vary for immature oocytes collected from different clinical sources to potentially develop into embryos and achieve live birth. As an effective treatment method, IVM can be used to treat patients with polycystic ovary syndrome (PCOS), ovarian hyperresponsiveness, and hyporesponsiveness, as well as to preserve the fertility of cancer patients. This technology has been used worldwide for the birth of thousands of healthy babies. The improvement in clinical IVM technology mainly focuses on the IVM medium and the optimization of the culture environment and operation process. At present, with the improvement in the in vitro fertilization (IVF) efficiency and culture systems, a natural cycle or mild stimulation may be more suitable for women receiving IVF treatments. A new treatment option was proposed to combine natural cycle/ mild stimulation IVF with IVM. In particular, the combination of mild stimulation IVF and IVM is not only expected to become a viable alternative to current standard treatments but may also become a potential option of first-line treatment.

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Section: Clinical Application and Safety Of Ivmmentioning

confidence: 85%

Clinical Application of In Vitro Maturation of Oocytes

La¹,

Zhao²,

Wang³

2019

Embryology - Theory and Practice

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“…31,35,36 As is often the case with newly emerging IVF technologies, safety data are limited, but early reports on both the obstetric outcomes of pregnancies following IVM and the resulting health of the children are promising. [37][38][39][40]…”

Section: In Vitro Maturationmentioning

confidence: 99%

“…With improved IVM protocols and optimisation of IVM culture systems, success rates have improved, with reported meiotic maturation rates per cumulus‐oocyte complex (COC) of up to 70% and clinical pregnancy rates per embryo transfer of 35–43% . As is often the case with newly emerging IVF technologies, safety data are limited, but early reports on both the obstetric outcomes of pregnancies following IVM and the resulting health of the children are promising …”

Section: Introductionmentioning

confidence: 99%

In vitro fertilisation/intracytoplasmic sperm injection beyond 2020

Crawford

Ledger

2018

BJOG

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Over 8 million babies have been born following IVF (in vitro fertilisation) and other artificial reproductive technology (ART) procedures since Louise Brown's birth 40 years ago. New innovations have added much complexity to both clinical and laboratory procedures over the last four decades. Translation of novel approaches from basic science into clinical practice continues unabated, widening the applicability of ART to new groups of people and helping improve both chances of healthy live birth and patient acceptability. However, the impact of ART on the health of both patients and their offspring continues to cause concern, and many ethical challenges created by new scientific developments in this field attract widely differing opinions. What is undeniable is that there will be a sustained global growth in utilisation of ART and that reproductive tourism will allow many people to access the treatment they desire notwithstanding national regulations that may forbid some approaches. The greatest challenge is to expand access to ART to those living in the less wealthy nations who are equally deserving of its benefits.

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“…With respect to embryonic development, our group have reported an increase in early embryo arrest in women with PCOS after IVM as compared to women with PCOS undergoing standard ICSI using time-lapse analysis, although no difference was recorded in the morphokinetic development of the useable embryos between the groups [ 19 ]. We have also noted that PCOS-IVM oocytes were significantly larger as compared to the oocytes of women from PCOS-ICSI and control-ICSI groups [ 61 ]. These differences had been attributed to the in vitro maturation process with inadequate completion through the stages of cytoplasmic maturation.…”

Section: Safety Of Ivmmentioning

confidence: 99%

The Place of In Vitro Maturation in PCO/PCOS

Julania

Walls²,

Hart³

2018

International Journal of Endocrinology

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In vitro maturation (IVM) of human oocytes is an emerging treatment option for women with polycystic ovary/polycystic ovary syndrome (PCO/PCOS) in addition to the standard in vitro fertilization (IVF) treatment. There has been significant improvements in pregnancy rates with IVM over the last two decades. This article reviews the place of IVM for women with PCO/PCOS, placing an emphasis on the predictors of successful pregnancy, optimization of culture media, IVM protocols, pregnancy rates, and neonatal outcomes following IVM treatment.

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Structural and morphologic differences in human oocytes after in vitro maturation compared with standard in vitro fertilization

Abstract: This study suggests that oocyte size and texture differ in the early stages of the first cell cycle.

Cited by 17 publications

References 26 publications

Clinical Application of In Vitro Maturation of Oocytes

Clinical Application of In Vitro Maturation of Oocytes

In vitro fertilisation/intracytoplasmic sperm injection beyond 2020

The Place of In Vitro Maturation in PCO/PCOS

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