Structural and functional reorganization of contralateral hippocampus after temporal lobe epilepsy surgery

Li, Wei; Jiang, Yuchao; Qin, Yingjie; Zhou, Baiwan; Lei, Du; Zhang, Heng; Lei, Ding; Yao, Dezhong; Luo, Cheng; Gong, Qiyong; Zhou, Dong; An, Dongmei

doi:10.1016/j.nicl.2021.102714

Cited by 6 publications

(8 citation statements)

References 48 publications

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“…All participants were native Chinese speakers and right‐handed assessed by the Edinburgh Inventory handedness test. All participants were the same as our previous study 22 exploring structural and functional reorganization of contralateral hippocampus after TLE surgery.…”

Section: Resultsmentioning

confidence: 99%

“…SPM12 (http://www.fil.ion.ucl.ac.uk/spm/) was applied for preprocessing. We flipped T1 images of right‐sided mTLE patients (9/28) and according matched HC to obtain the ipsilateral and contralateral datasets, similar to our previous study 22 . There was evidence that gray matter structural compromise equally distributed in left and right TLE 25 .…”

Section: Methodsmentioning

confidence: 99%

“…We flipped T1 images of right-sided mTLE patients (9/28) and according matched HC to obtain the ipsilateral and contralateral datasets, similar to our previous study. 22 There was evidence that gray matter structural compromise equally distributed in left and right TLE. 25 Preoperative images were co-registered to a symmetric Montreal Neurological Institute (MNI) template using a nonlinear transformation function.…”

Section: Image Processingmentioning

confidence: 99%

“…All participants were the same as our previous study 22 exploring structural and functional reorganization of contralateral hippocampus after TLE surgery.…”

Section: Clinical Datamentioning

confidence: 99%

“…We previously studied dynamic changes of white matter diffusion, gray matter volume, and intrinsic brain activity in mTLE patients who achieved seizure freedom after ATL at five serial timepoints: before surgery, 3, 6, 12 and 24 months after surgery. 21,22 In the current study, we aimed to explore dynamic cortical thickness alterations after successful TLE surgery and to confirm postoperative cortical remodeling. Age-and gender-matched healthy controls (HC) were also recruited.…”

Section: Introductionmentioning

confidence: 99%

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Cortical remodeling before and after successful temporal lobe epilepsy surgery

Jiang

Qin

et al. 2022

Acta Neuro Scandinavica

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Objectives To explore dynamic alterations of cortical thickness before and after successful anterior temporal lobectomy (ATL) in patients with unilateral mesial temporal lobe epilepsy (mTLE). Materials and Methods High‐resolution T1‐weighted MRI was obtained in 28 mTLE patients who achieved seizure freedom for at least 24 months after ATL and 29 healthy controls. Patients were scanned at five timepoints, including before surgery, 3, 6, 12 and 24 months after surgery. Preoperative cortical thickness of mTLE patients were compared with healthy controls. Dynamic alterations of cortical thickness before and after surgery were compared among five scans using linear mixed models. Results Patients with mTLE showed cortical thinning pre‐surgically in ipsilateral entorhinal cortex, parahippocampal gyrus, inferior parietal cortex, lateral occipital cortex; contralateral pericalcarine cortex (PCC); and bilateral caudal middle frontal gyrus (cMFG), paracentral lobule, precentral gyrus (PCG), superior parietal cortex. Cortical thickening was observed in contralateral rostral anterior cingulate cortex (rACC). Patients showed postsurgical cortical thinning in ipsilateral temporal lobe, fusiform gyrus, caudal anterior cingulate cortex, lingual gyrus, and insula. Ipsilateral cMFG, PCC, and contralateral PCG showed significant cortical thickening after surgery. In addition, contralateral rACC showed cortical thickening at 3 months follow‐up, however, with obvious cortical thinning at 24 months follow‐up. Conclusions Mesial temporal lobe epilepsy patients showed widespread cortical thinning before and after anterior temporal lobectomy. Progressive cortical thinning mainly existed in neighboring regions of resection. Postoperative cortical thickening may indicate cortical remodeling after successful surgery.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Image Processingmentioning

confidence: 99%

“…All participants were the same as our previous study 22 exploring structural and functional reorganization of contralateral hippocampus after TLE surgery.…”

Section: Clinical Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cortical remodeling before and after successful temporal lobe epilepsy surgery

Jiang

Qin

et al. 2022

Acta Neuro Scandinavica

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Longitudinal hippocampal diffusion‐weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy

et al. 2022

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High-resolution (1 mm isotropic) diffusion tensor imaging (DTI) of the hippocampus in temporal lobe epilepsy (TLE) patients has shown patterns of hippocampal subfield diffusion abnormalities, which were consistent with hippocampal sclerosis (HS) subtype on surgical histology. The objectives of this longitudinal imaging study were to determine the stability of focal hippocampus diffusion changes over time in TLE patients, compare diffusion and quantitative T2 abnormalities of the sclerotic hippocampus, and correlate presurgical mean diffusivity (MD) and T2 maps with postsurgical histology. Methods: Nineteen TLE patients and 19 controls underwent two high-resolution(1 mm isotropic) DTI and 1.1 × 1.1 × 1 mm 3 T2 relaxometry scans (in a subset of 16 TLE patients and 9 controls) of the hippocampus at 3T, with a 2.6 ± 0.8 year inter-scan interval. Within-participant hippocampal volume, MD and T2 were compared between the scans. Contralateral hippocampal changes 2.3 ± 1.0 years after surgery and ipsilateral preoperative MD maps versus postoperative subfield histopathology were evaluated in eight patients who underwent surgical resection of the hippocampus.Results: Reduced volume and elevated MD and T2 of sclerotic hippocampi remained unchanged between longitudinal scans. Focal regions of elevated MD and T2 in bilateral hippocampi of HS TLE were detected consistently at both scans. Regions of high MD and T2 correlated and remained consistent over time.Volume, MD, and T2 remained unchanged in postoperative contralateral hippocampus. Regional elevations of MD identified subfield neuron loss on postsurgical histology with 88% sensitivity and 88% specificity. Focal T2 elevations identified subfield neuron loss with 75% sensitivity and 88% specificity.

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