Structural and Dynamic Response of Neutral and Intelligent Networks in Biomedical Environments

Lowman, Anthony M.; Dziubla, Thomas D.; Bureš, Petr; Peppas, Nicholas A.

doi:10.1016/s0065-2377(03)29004-9

Cited by 29 publications

(24 citation statements)

References 223 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to mechanical properties such as the Young’s modulus ( E ), storage modulus ( G ′), and loss modulus ( G ″) [3], the hydrogel structure can be quantitatively modeled using several parameters: v 2, s is the polymer volume fraction in the swollen state, which describes the hydrogel’s hydration level;

\bar{M_{C}}

is the average molecular weight between crosslinks, which describes the overall density of crosslinks in the hydrogel; and ξ is the mesh size of the hydrogel, which reflects the porosity of the gel (and is dependent on the hydration level and the crosslinking density). These parameters can be used to model the behavior of both nonionic [4] and ionic [5] hydrogels through equilibrium swelling theory and rubber elasticity theory [6]. …”

Section: General Hydrogel Theorymentioning

confidence: 99%

Stimulus-responsive hydrogels: Theory, modern advances, and applications

Koetting

Peters

Steichen

et al. 2015

Materials Science and Engineering: R: Reports

Self Cite

897

688

View full text Add to dashboard Cite

Over the past century, hydrogels have emerged as effective materials for an immense variety of applications. The unique network structure of hydrogels enables very high levels of hydrophilicity and biocompatibility, while at the same time exhibiting the soft physical properties associated with living tissue, making them ideal biomaterials. Stimulus-responsive hydrogels have been especially impactful, allowing for unprecedented levels of control over material properties in response to external cues. This enhanced control has enabled groundbreaking advances in healthcare, allowing for more effective treatment of a vast array of diseases and improved approaches for tissue engineering and wound healing. In this extensive review, we identify and discuss the multitude of response modalities that have been developed, including temperature, pH, chemical, light, electro, and shear-sensitive hydrogels. We discuss the theoretical analysis of hydrogel properties and the mechanisms used to create these responses, highlighting both the pioneering and most recent work in all of these fields. Finally, we review the many current and proposed applications of these hydrogels in medicine and industry.

show abstract

\bar{M_{C}}

Section: General Hydrogel Theorymentioning

confidence: 99%

Stimulus-responsive hydrogels: Theory, modern advances, and applications

Koetting

Peters

Steichen

et al. 2015

Materials Science and Engineering: R: Reports

Self Cite

897

688

View full text Add to dashboard Cite

show abstract

“…Recently, a few approaches have focused on engineering bioactive hydrogels by combining nHAp with hydrophilic polymers such as poly(ethylene glycol) (PEG), polyacrylamide (PAAm), poly(vinyl alcohol) (PVA), alginate, carrageenan, gelatin, and collagen . This variety of polymers has expanded the use of nHAp in nanocomposite hydrogels, allowing for tailored functionality . However, most of these nanocomposite scaffolds are designed for use as scaffolds and very few studies focus on engineering nanocomposite hydrogels that can be easily injected.…”

Section: Introductionmentioning

confidence: 99%

Photocrosslinkable and elastomeric hydrogels for bone regeneration

Thakur

Xavier

Cross

et al. 2016

J Biomedical Materials Res

View full text Add to dashboard Cite

Nanocomposite biomaterials are extensively investigated for cell and tissue engineering applications due their unique physical, chemical and biological characteristics. Here, we investigated the mechanical, rheological, and degradation properties of photocrosslinkable and elastomeric nanocomposite hydrogels from nanohydroxyapatite (nHAp) and gelatin methacryloyl (GelMA). The addition of nHAp resulted in a significant increase in mechanical stiffness and physiological stability. Cells readily adhere and proliferate on the nanocomposite surfaces. Cyclic stretching of cells on the elastomeric nanocomposites revealed that nHAp elicited a stronger alignment response in the direction of strain. In vitro studies highlight enhanced bioactivity of nanocomposites as determined by alkaline phosphate (ALP) activity. Overall, the elastomeric and photocrosslinkable nanocomposite hydrogels can be used for minimally invasive therapy for bone regeneration.

show abstract

“…Over the last 25 years, hydrogels have become popular carriers for drug delivery applications due to their biocompatibility and resemblance to biological tissues [1][2][3][4][5][6]. From a structural point of view, hydrogels are three-dimensional hydrophilic polymer networks that swell in water or biological fluids without dissolving as a result of chemical or physical crosslinks [7].…”

Section: Introductionmentioning

confidence: 99%