Stimulus-responsive hydrogels: Theory, modern advances, and applications

Koetting, Michael C.; Peters, Jonathan T.; Steichen, Stephanie D.; Peppas, Nicholas A.

doi:10.1016/j.mser.2015.04.001

Cited by 894 publications

(711 citation statements)

References 496 publications

(638 reference statements)

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“…Well-studied hydrogel chemistries include synthetics such as acrylamide, PEG and PVA, and biopolymers such as cellulose [102] and gelatin [103]. A general review of the theory used to understand stimuli-responsive hydrogels, and the multitude of work on the subject, can be found in Koetting [104].…”

Section: Plant Tissues-volume-changementioning

confidence: 99%

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

2016

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Shape-changing materials open an entirely new solution space for a wide range of disciplines: from architecture that responds to the environment and medical devices that unpack inside the body, to passive sensors and novel robotic actuators. While synthetic shape-changing materials are still in their infancy, studies of biological morphing materials have revealed key paradigms and features which underlie efficient natural shape-change. Here, we review some of these insights and how they have been, or may be, translated to artificial solutions. We focus on soft matter due to its prevalence in nature, compatibility with users and potential for novel design. Initially, we review examples of natural shape-changing materials-skeletal muscle, tendons and plant tissues-and compare with synthetic examples with similar methods of operation. Stimuli to motion are outlined in general principle, with examples of their use and potential in manufactured systems. Anisotropy is identified as a crucial element in directing shape-change to fulfil designed tasks, and some manufacturing routes to its achievement are highlighted. We conclude with potential directions for future work, including the simultaneous development of materials and manufacturing techniques and the hierarchical combination of effects at multiple length scales.

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Section: Plant Tissues-volume-changementioning

confidence: 99%

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

2016

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“…Stimulus-responsive hydrogels have been a topic of extensive research in the past few decades [1]. Their ability to modify their internal structure based on external stimuli allows for dynamic control over flows in biological [2,3] * khjensen@fysik.dtu.dk or man-made systems [1,4] (Fig.…”

Section: Flows In Active Porous Mediamentioning

confidence: 99%

Transient flows in active porous media

Kosmidis

Jensen

2017

Phys. Rev. E

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Stimuli-responsive materials that modify their shape in response to changes in environmental conditions-such as solute concentration, temperature, pH, and stress-are widespread in nature and technology. Applications include micro-and nanoporous materials used in filtration and flow control. The physiochemical mechanisms that induce internal volume modifications have been widely studied. The coupling between induced volume changes and solute transport through porous materials, however, is not well understood. Here, we consider advective and diffusive transport through a small channel linking two large reservoirs. A section of stimulus-responsive material regulates the channel permeability, which is a function of the local solute concentration. We derive an exact solution to the coupled transport problem and demonstrate the existence of a flow regime in which the steady state is reached via a damped oscillation around the equilibrium concentration value. Finally, the feasibility of an experimental observation of the phenomena is discussed.

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“…Smart hydrogels exhibit significant physical and chemical changes in response to slight changes in their environment [5]. These also belong to the group of hydrogels which are sensitive to external stimuli [6]. These materials can synthesize in response to a number of physiological stimuli present in organism, such as pH, ionic strength and temperature [2].…”

Section: Introductionmentioning

confidence: 99%

“…By varying these, the material properties such as a degree of swelling, porosity, a physical structure, etc. can be affected [6]. The arising changes are reversible.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

Urošević¹,

Nikolić²,

Ilić‐Stojanović³

et al. 2018

Adv Techol

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Hydrogels are three-dimensional polymer networks which have the capacity to retain a large quantity of water or biological fluids in the swollen state. Thermosensitive hydrogels have received special attention of reserachers since they represent a parameter which frequently changes in chemical, biological and physiological systems. Thermosensitive hydrogels have the critical solution temperature, i.e. they exhibit a substantial change in volume with the temperature change. Homopolymers poly(N-isopropylmethacrylamide) (poly(NIPMAM)) and poly(N-isopropylacrylamide) (poly(NIPAM)) are thermosensitive materials which have lately become the subject of intensive study. Monomer N-isopropylmethacrylamide, NIPMAM, enters into copolymerization with monomer N-isopropylacrylamide, NIPAM, in order to create a system with a phase transition temperature approximate to the human body temperature. In literature data there is available information on the synthesis and characterization of microgels, nanogels and copolymers based on NIPMAM and NIPAM. These thermosensitive polymer materials are used in controlled drug delivery and protein immobilization.

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Stimulus-responsive hydrogels: Theory, modern advances, and applications

Cited by 894 publications

References 496 publications

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

Morphing in nature and beyond: a review of natural and synthetic shape-changing materials and mechanisms

Transient flows in active porous media

Hydrogels based on N-isopropylmethacrylamide and N-isopropylacrylamide

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