Structural and biological evaluation of novel vanadium/Yttrium co-doped hydroxyapatite for bone tissue engineering applications

Megha, M.; Joy, Anjumol; Unnikrishnan, Gayathri; Jayan, Manoj; Haris, M.; Thomas, Jibu; Kolanthai, Elayaraja; Muthuswamy, Senthilkumar

doi:10.1016/j.jallcom.2023.171697

Cited by 5 publications

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is the primary mineral component found in the bones and dental tissues and therefore portrays excellent biocompatibility. Also, the nanocrystalline as well as carbonated HAp nanoparticles are regarded as biological apatite, due to the presence of OH and calcium groups [ 4 , 5 ]. Aside from the dental or bone implant applications, the HAp nanoparticles are recently being utilized as drug carriers with enhanced adsorption over the biological boundaries, for controlled and targeted delivery of drugs [ 147 – 149 ].…”

Section: Inorganic and Organic Nanoparticlesmentioning

confidence: 99%

“…The substantial amount of effort taken in the synthesis and modification of nanomaterials has resulted in the advancement of the utilization of nanoparticles for various biomedical applications such as gene/drug delivery, orthopedic implants, tissue engineering [ 4 , 5 ], bone regeneration, magnetic resonance imaging (MRI), and cancer treatment [ 6 , 7 ]. Nanoparticle-based drug delivery systems have arisen as an assuring methodology for the improvement of the efficiency of prevailing drugs and also to enable the advancement of new therapies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

Self Cite

View full text Add to dashboard Cite

The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstract

show abstract