Development and application of hydroxyapatite-based scaffolds for bone tissue regeneration: A systematic literature review

Fendi, Fendi; Abdullah, Bualkar; Suryani, Sri; Usman, Andi Nilawati; Tahir, Dahlang

doi:10.1016/j.bone.2024.117075

Cited by 11 publications

(5 citation statements)

References 90 publications

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“…where ρ a (g/cm 3 ) is the apparent density of the sample, W 1 (g) is the dry weight, W 2 (g) is the weight measured in deionized water, W 3 (g) is the saturated weight, and ρ water is the density of water (1 g/cm 3 ). The relative density of the sample was then calculated using the formula…”

Section: Methodsmentioning

confidence: 99%

“…where ρ r (%) is the relative density of the sample, and ρ th (g/cm 3 ) is the theoretical density of the sample. The samples were sequentially ground with #400, #800, #1200, #1500, and #2000 sandpapers, followed by polishing with a 1 µm diamond lapping film.…”

Section: Methodsmentioning

confidence: 99%

“…The global incidence of fractures is 99 cases per 100,000 people annually [1]. Hydroxyapatite (HA) is well regarded for its bioactivity, cell adhesion, cell proliferation [2], and osteoconductivity [3], making it a prominent material in biomedical applications. Due to its ability to form bonds with bone tissue, HA is extensively utilized as a bone replacement and graft material [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Enhancing Bioactivity and Mechanical Properties of Nano-Hydroxyapatite Derived from Oyster Shells through Hydrothermal Synthesis

Wu,

Hsu,

et al. 2024

Nanomaterials

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Nano-hydroxyapatite (nHA) demonstrates favorable biological activity, cell adhesion, cell proliferation, and osteoconductivity, making it highly valuable in biomedicine. It is extensively used as a bone substitute and in bone transplantation within the dental and orthopedic fields. This study employed oyster shells as a calcium source to synthesize nHA at 150 °C with various hydrothermal reaction durations (10 min, 1 h, 6 h, and 12 h). As a control, HA synthesized via a wet precipitation method for 1 h at room temperature was utilized. Subsequent material analyses, including XRD, FE-SEM, FTIR, and ICP-MS, were conducted, followed by comprehensive evaluations of the bioactivity, cell attachment, cell proliferation, and sintering properties of the synthesized nHA. The results indicated that nHA synthesized through the hydrothermal reaction produced nanoscale crystals, with the aspect ratio of nHA particles increasing with the duration of hydrothermal treatment. Notably, rod-like nHA particles became prominent with hydrothermal durations exceeding 6 h. nHA particles derived from oyster shells contained carbonate and trace elements (Na, Mg, K, and Sr), similar to constituents found in human hard tissue such as bone and teeth. The immersion of nHA synthesized at 150 °C for 1 h (HT2) in simulated body fluid (SBF) for 28 d led to the formation of a bone-like apatite layer on the surface, indicating the excellent bioactivity of the synthesized nHA. The cell culture results revealed superior cell attachment and proliferation for nHA (HT2). Following the sequential formation and sintering at 1200 °C for 4 h, HT2 ceramics exhibited enhanced microhardness (5.65 GPa) and fracture toughness (1.23 MPa·m0.5), surpassing those of human tooth enamel.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhancing Bioactivity and Mechanical Properties of Nano-Hydroxyapatite Derived from Oyster Shells through Hydrothermal Synthesis

Wu,

Hsu,

et al. 2024

Nanomaterials

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“…Bone scaffolds possess a porous microstructure which imitates the extracellular matrix (ECM) and ideally creates an appropriate regenerative microenvironment due to their biocompatibility [4], adequate mechanical properties, and biodegradability [5]. Among numerous biomaterials used for bone scaffolds, calcium phosphate-based ones, such as hydroxyapatite (HAp), are becoming increasingly attractive due to their chemical resemblance to the inorganic components of human bones and teeth [6]. HAp has a wide range of biomedical applications including bone scaffold implantation [7] and coating materials.…”

Section: Introductionmentioning

confidence: 99%

“…While HAp (Ca10(PO4)6(OH)2) is relatively simple to produce and possesses low toxicity, high biocompatibility and bioactivity, its intrinsic mechanical weakness (brittleness and powdery characteristics) often requires combination with other materials. These materials include natural polymers (chitosan, silk fibroin, collagen, hyaluronic acid), synthetic polymers (polylactic acid, polycaprolactone, poly-lactic-co-glycolide acid), [12] and different ions (magnesium, zinc, lithium and others) [6]. Also, it has been recognized that the HAp particle size is an important factor in the regeneration process, and that nanohydroxyapatite (nHAp) with smaller (1-100 nm) particles possesses the most desirable traits, partly due to their huge surface-to-volume ratio and faster resorption followed by new bone formation [13].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Nano-Hydroxyapatite Scaffold Enrichment on Bone Regeneration In Vivo—A Systematic Review

Mitić,

Čarkić,

Jaćimović

et al. 2024

Biomimetics

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Objectives: In order to ensure improved and accelerated bone regeneration, nano-hydroxyapatite scaffolds are often enriched with different bioactive components to further accelerate and improve bone healing. In this review, we critically examined whether the enrichment of nHAp/polymer scaffolds with growth factors, hormones, polypeptides, microRNAs and exosomes improved new bone formation in vivo. Materials and Methods: Out of 2989 articles obtained from the literature search, 106 papers were read in full, and only 12 articles met the inclusion criteria for this review. Results: Several bioactive components were reported to stimulate accelerated bone regeneration in a variety of bone defect models, showing better results than bone grafting with nHAp scaffolds alone. Conclusions: The results indicated that composite materials based on nHAp are excellent candidates as bone substitutes, while nHAp scaffold enrichment further accelerates bone regeneration. The standardization of animal models should be provided in order to clearly define the most significant parameters of in vivo studies. Only in this way can the adequate comparison of findings from different in vivo studies be possible, further advancing our knowledge on bone regeneration and enabling its translation to clinical settings.

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Hydroxyapatite Extracted from Rabbitfish (Siganus sp.) Bones and Its Potential for Bone Tissue Engineering Applications

Fendi,

Abdullah,

Suryani

et al. 2024

JOM

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Development and application of hydroxyapatite-based scaffolds for bone tissue regeneration: A systematic literature review

Cited by 11 publications

References 90 publications

Enhancing Bioactivity and Mechanical Properties of Nano-Hydroxyapatite Derived from Oyster Shells through Hydrothermal Synthesis

Enhancing Bioactivity and Mechanical Properties of Nano-Hydroxyapatite Derived from Oyster Shells through Hydrothermal Synthesis

The Impact of Nano-Hydroxyapatite Scaffold Enrichment on Bone Regeneration In Vivo—A Systematic Review

Hydroxyapatite Extracted from Rabbitfish (Siganus sp.) Bones and Its Potential for Bone Tissue Engineering Applications

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