Structural and biochemical characterization of TRAF5 from Notothenia coriiceps and its implications in fish immune cell signaling

Kim, Chang Min; Jang, Hyun-Seok; Ha, Hyekyung; Kim, Gi Eob; Park, Hyun Ho

doi:10.1016/j.fsi.2020.04.016

Cited by 4 publications

(3 citation statements)

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“…Traf proteins are important signal adaptors and are found widely in various animals and plants, such as humans (Zhu et al ., 2018), Notothenia coriiceps (Kim et al ., 2020), Hyriopsis cumingii (Huang et al ., 2018) and Arabidopsis thaliana (Qi et al ., 2017). Previous studies have also confirmed that they are closely related to congenital immunity (Chen et al ., 2016; Gil et al ., 2004; Ha et al ., 2009; Shi & Sun, 2018 Walsh et al ., 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Different coloured boxes indicate the 14 putative motifs. Traf, tumour necrosis factor (TNF) receptor-associated factor 4.1 | Identification and evolution of traf genesTraf proteins are important signal adaptors and are found widely in various animals and plants, such as humans(Zhu et al, 2018), Notothenia coriiceps(Kim et al, 2020), Hyriopsis cumingii(Huang et al, 2018)…”

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confidence: 99%

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Genome‐wide identification of the traf gene family in yellow catfish (Pelteobagrus fulvidraco) and analysis of their expression in response to bacterial challenge

Nie

Wang

Zhang

et al. 2022

Journal of Fish Biology

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Tumour necrosis factor (TNF) receptor‐associated factor (TRAF) is a receptor protein that has important functions in the immune system. Nonetheless, there have been few reports of traf genes in teleost fishes. The present study aimed to identify the traf genes from the genomic information of yellow catfish (Pelteobagrus fulvidraco). Eight traf genes were identified and named, which are distributed on different chromosomes but have similar conserved protein domains. Phylogenetic and syntenic analyses demonstrated conservation of traf genes during evolution. In addition, yellow catfish has the relatively rare traf1 and traf5 genes. Gene structure and motif analysis revealed the homology and distribution diversity of the traf genes. Quantitative real‐time reverse transcription PCR was used to study the expression patterns of traf genes in healthy fish tissues and after infection by Aeromonas hydrophila. The results demonstrated significant changes in traf gene expression, indicating a potential role in innate immunity.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Genome‐wide identification of the traf gene family in yellow catfish (Pelteobagrus fulvidraco) and analysis of their expression in response to bacterial challenge

Nie

Wang

Zhang

et al. 2022

Journal of Fish Biology

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“…TRAF5 is much less studied than TRAF3, although TRAF5 shares the highest sequence with TRAF3 in the TRAF family (Foight and Keating, 2016;Kim et al, 2020). Similarly, TRAF5 contains an N-terminal RING domain, five zinc fingers at the middle of its sequence, a coiled-coil domain, and a MATH domain included in the C-terminal TRAF domain (Xu et al, 2020).…”

Section: Traf5mentioning

confidence: 99%

Roles of TRAFs in Ischemia-Reperfusion Injury

Wei

Lin

Zhong

et al. 2020

Front. Cell Dev. Biol.

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Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. These TRAFdependent signaling pathways and physiological functions have been involved in the occurrence and progression of ischemia-reperfusion injury (IRI), which is a common pathophysiological process that occurs in a wide variety of clinical events, including ischemic shock, organ transplantation, and thrombolytic therapy, resulting in a poor prognosis and high mortality. IRI occurs in multiple organs, including liver, kidney, heart, lung, brain, intestine, and retina. In recent years, mounting compelling evidence has confirmed that the genetic alterations of TRAFs can cause subversive phenotype changes during IRI of those organs. In this review, based on current knowledge, we summarized and analyzed the regulatory effect of TRAFs on the IRI of various organs, providing clear direction and a firm theoretical basis for the development of treatment strategies to manipulate TRAF proteins or TRAF-dependent signaling pathways in IRI-related diseases.

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TRAF5 splicing variants associate with TRAF3 and RIP1 in NF-κB and type I IFN signaling in large yellow croaker Larimichthys crocea

Tang¹,

Liu²,

Wang³

et al. 2022

Fish & Shellfish Immunology

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Structural and biochemical characterization of TRAF5 from Notothenia coriiceps and its implications in fish immune cell signaling

Cited by 4 publications

References 39 publications

Genome‐wide identification of the traf gene family in yellow catfish (Pelteobagrus fulvidraco) and analysis of their expression in response to bacterial challenge

Genome‐wide identification of the traf gene family in yellow catfish (Pelteobagrus fulvidraco) and analysis of their expression in response to bacterial challenge

Roles of TRAFs in Ischemia-Reperfusion Injury

TRAF5 splicing variants associate with TRAF3 and RIP1 in NF-κB and type I IFN signaling in large yellow croaker Larimichthys crocea

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