Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors

Stevia rebaudiana Bertoni: health promoting properties and therapeutic applications

“…In healthy individuals, the activity of monocytes is improved. Mizushina et al (2005) showed that isosteviol, as product by acid hydrolysis of the steviol glycoside, strongly inhibits DNA polymerase and topoisomerase II, in this way delaying the growth of three types of cancer cells. Yingkun et al (2013) conducted experiments on male BALB/c mice, which were administered stevioside or dexamethasone 1 h before nasal instillation of lipopolysaccharide, causing acute lung injury.…”

4-Hydroxyderricin from Angelica keiskei Roots Induces Caspase-dependent Apoptotic Cell Death in HL60 Human Leukemia Cells

“…2.8 DNA Topoisomerase inhibition assay DNA Topo I and II inhibition assays were performed according to the previous method 19,20 .…”

Stevioside and rebaudioside A - predominant ent-kaurene diterpene glycosides of therapeutic potential: a review

“…On the other hand, the lack of toxicity was also observed in subchronic studies after giving the maximum dose of 600 mg/kg BW/day (Xili et al 1992). The stevioside hydrolysed product isosteviol inhibits the human cancer cell growth in vitro (with LD 50 values of 84 to 167 μmol) and DNA replication (Mizushina et al 2005).…”

“…Besides sweetness, various medicinal activities of stevioside and rebaudioside A have been identified which include antihyperglycaemic ( Jeppesen et al 2002;Gregersen et al 2004), antineoplastic (Mizushina et al 2005), anticariogenic (Das et al 1992), antihypertensive (Chan et al 2000), antiinflammatory (Yasukawa 2002), and antioxidant activity (Žlabur et al 2015). Currently, numerous reviews have been published concerning the valuable and abundant potential of steviol glycosides as a sweetener in beverages and variety of food products including soy sauce, sea foods, pickled vegetables, and confectionary or bakery products.…”