Structural alterations in <i>Candida albicans</i> by caffeine and caffeine salts

Mittag, H.

doi:10.1111/myc.1994.37.9-10.337

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Such giant forms of Candida may occur after antifungal therapy or, in vitro after exposure of Candida to subinhibitory concentrations of caffeine. 26,27 However, none of these fungi are reported to show the characteristic pilot's wheel appearance of Paracoccidioides.…”

Section: Discussionmentioning

confidence: 98%

Paracoccidioides brasiliensis in a liquid‐based Papanicolaou test from a pregnant woman: Report of a case

Alsharif

Martin

Shelton

et al. 2008

Diagnostic Cytopathology

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With the exception of Candida species, fungal organisms are rarely encountered in the Papanicolaou test and, when encountered, usually represent contaminants rather then infections. We present the case of a healthy 29-year-old pregnant female, gravida 1, para 0, who presented for her first prenatal visit at 12-week gestation and had many large fungal-like elements with a distinct budding pattern of multiple narrow-based buds resembling a "ship's-wheel" identified in her routine liquid-based Papanicolaou test. Based on its characteristic appearance in the Papanicolaou test and the hematoxylin and eosin, periodic acid Schiff and Gomori's methenamine silver stains performed on the cell block made from the residual sample, the fungus was diagnosed as "consistent with Paracoccidioides." This is the second reported case of Paracoccidioides presenting in a Papanicolaou test and shows that this organism may rarely involve the uterine cervix in the absence of clinical systemic disease.

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Section: Discussionmentioning

confidence: 98%

Paracoccidioides brasiliensis in a liquid‐based Papanicolaou test from a pregnant woman: Report of a case

Alsharif

Martin

Shelton

et al. 2008

Diagnostic Cytopathology

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“…In one study, caffeine enhanced the antifungal activity of chloroquine through induction of the cell wall perturbation [ 33 ]. Caffeine and its salts caused alterations in the structure of C. albicans in the Mittag study [ 34 ]. Sabie and Gadd reported that caffeine and other phosphodiesterase inhibitors might induce yeast–mycelium transition of C. albicans [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Antifungal and Antibiofilm Activities of Caffeine against Candida albicans on Polymethyl Methacrylate Denture Base Material

et al. 2022

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Background: In this study, the effect of pure caffeine was established against Candida albicans (C. albicans) using different microbiological techniques. Methods: Broth microdilution and colony forming units (CFUs) assays were used to detect the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC). The Live/Dead fluorescent dyes were implemented to determine the yeast viability. Polymethyl methacrylate acrylic resin (PMMA) discs were prepared to evaluate caffeine’s effects against adherent C. albicans using microplate reader, CFUs, and scanning electron microscope (SEM). Results: caffeine’s MIC was detected around 30 mg/mL, while the MFC was considered at 60 mg/mL. In an agar-well diffusion test, the inhibition zones were wider in caffeine groups. The Live/Dead viability test verified caffeine’s antifungal effects. The optical density of the adherent C. albicans on PMMA discs were lower at 620 nm or 410 nm in caffeine groups. CFU count was also reduced by caffeine treatments. SEM revealed the lower adherent C. albicans count in caffeine groups. The effect of caffeine was dose-dependent at which the 60 mg/mL dose demonstrated the most prominent effect. Conclusion: The study reinforced caffeine’s antifungal and antibiofilm properties and suggested it as an additive, or even an alternative, disinfectant solution for fungal biofilms on denture surfaces.

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“…Also, Mittag (1994) observed partial inhibition of the growth and structural changes in Cand~a albicans with caffeine concentrations lower than 5 mg/ml (0.5%). YE induced PL similarly to caffeine, though MDW and PL activity were approximately twice as high when equivalent concentrations of YE and caffeine were compared ( Figure IB Tea extract (TE), at concentrations of 0 to 0.25%, with 0.4% sucrose, increased PL activity while the growth of 1).…”

Section: A)mentioning

confidence: 99%

Pectin lyase production by Penicillium griseoroseum: Effect of tea extract, caffeine, yeast extract, and pectin

et al. 1996

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Mycelial growth and production of extracellular pectin lyase by Penicillium griseoroseum at different concentrations of inducers were investigated. The fungus was cultured in mineral medium using sucrose as a carbon source and caffeine, yeast extract, tea extract or pectin as inducers. Caffeine, yeast extract and tea extract in the presence of sucrose, and tea extract alone were capable of inducing pectin lyase in P. griseoroseum, even at low concentrations.

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Structural alterations in Candida albicans by caffeine and caffeine salts

Cited by 7 publications

References 15 publications

Paracoccidioides brasiliensis in a liquid‐based Papanicolaou test from a pregnant woman: Report of a case

Paracoccidioides brasiliensis in a liquid‐based Papanicolaou test from a pregnant woman: Report of a case

The Antifungal and Antibiofilm Activities of Caffeine against Candida albicans on Polymethyl Methacrylate Denture Base Material

Pectin lyase production by Penicillium griseoroseum: Effect of tea extract, caffeine, yeast extract, and pectin

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