Strontium‐modified titanium substrate promotes osteogenic differentiation of MSCs and implant osseointegration via upregulating CDH2

Abstract

Objectives: Our previous studies showed that strontium (Sr)-modified sand-blasted, large grit, acid etched titanium surface (Sr-SLA) is beneficial for osseointegration; however, the supporting mechanisms have not been explored in detail.

A Multifunctional Metal–Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation

“…Numerous studies demonstrate the influence of Sr 2+ on accelerating osteogenesis and augmenting osseointegration, the mechanisms involved in the activation of Wnt/β‐catenin, CaSR/PI3K/AKT, and NFATc/Maf pathways, which contribute to the bone anabolism in the initial stage. [ 32 , 74 , 75 , 76 ] On the other hand, TA can selectively inhibit osteoclast proliferation and differentiation probably via suppressing the RANK/RNAKL/OPG pathway. [ 77 ] To sum up, due to the synergistic effects between TA and Sr 2+ of alleviating oxidative damage, smoothly switching macrophages from M1 to M2, and facilitating osteoblast activity, TA‐Sr showed great potential in regulating the osteoimmune environment to a much more favorable condition so as to enhance osseointegration.…”

Convergence of Calcium Channel Regulation and Mechanotransduction in Skeletal Regenerative Biomaterial Design

“…[ 90 ] The Cad‐functionalized biomaterial surface was demonstrated to promote activation of the Wnt/β‐catenin pathway across seeded hMSCs, and correspondingly drive osteogenic differentiation, in situ bone formation, and integration at the bone–implant interface both in vitro and in vivo. Other biomaterial approaches to direct osteogenic differentiation and bone regeneration by modulating or mimicking cadherin/catenin have included micro/nanotopographies, [ 91 ] matrix dimensionality, [ 92 ] Sr 2+ ‐modified surfaces, [ 93 ] and polyelectrolyte‐based matrices. [ 94 ]…”

Effect of the Sr–Fe layered double hydroxide coating based on the microenvironment response on implant osseointegration in osteoporotic rats

“…Sr 2+ is a known biologically active ion that, at appropriate concentrations, [21][22][23] increases pro-osteoblast activity and inhibits osteoclast overactivity, thereby regulating bone metabolism and promoting osseointegration. [24][25][26][27][28] Layered double hydroxide (LDH), a biomaterial composed of a body laminate of divalent and trivalent cations and a guest laminate of anions, has been investigated extensively in the field of bone repair. 29,30 The formula for this substance is [M 1Àx 2+ N x 3+ (OH) 2 ] x+ [An x/n nÀ ] xÀ ÁmH 2 O. LDH's chemical composition is modifiable, and various biological effects can be conferred on LDH by introducing different bioactive elements.…”

“…Sr 2+ is a known biologically active ion that, at appropriate concentrations, 21–23 increases pro-osteoblast activity and inhibits osteoclast overactivity, thereby regulating bone metabolism and promoting osseointegration. 24–28…”