Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect

Grynpas, Marc D.; Hamilton, Emma; Cheung, R.; Tsouderos, Y; Deloffre, P.; Hott, M.; Marie, Pierre J.

doi:10.1016/8756-3282(95)00484-x

Cited by 198 publications

(142 citation statements)

References 22 publications

Supporting

Mentioning

121

Contrasting

Unclassified

Order By: Relevance

“…We also observed slight release of Sr ions from the experimental adhesive used in group 2. It has been confirmed that Sr ions are effective in inducing calcification during bone formation [33][34][35][36] . In addition, Ammann reported that Sr ions also promoted differentiation from pre-osteoblasts into osteoblasts and controlled the action of osteoclasts, thus promoting bone formation 37) .…”

Section: Discussionmentioning

confidence: 75%

“…Si and F ions, in particular, are known as strong inducers of remineralization of the dentin matrix [29][30][31][32] . It is also well known that B and Sr have osteogenic potential [33][34][35][36][37][38] . Sr promotes differentiation of pre-osteoblasts into osteoblasts [33][34][35][36][37] , and it inhibits osteoclast differentiation and activity 37) .…”

Section: Introductionmentioning

confidence: 99%

“…It is also well known that B and Sr have osteogenic potential [33][34][35][36][37][38] . Sr promotes differentiation of pre-osteoblasts into osteoblasts [33][34][35][36][37] , and it inhibits osteoclast differentiation and activity 37) . B is a trace element found in the human body that plays an important role in many life processes, including bone growth and maintenance 38) .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of an experimental adhesive resin containing multi-ion releasing fillers on direct pulp-capping

2016

View full text Add to dashboard Cite

The purpose of this study was to evaluate pulpal healing and reparative dentin formation after 14 and 28 days in exposed rat pulp directly capped with an experimentally developed all-in-one adhesive containing surface reaction-type pre-reacted glass-ionomer (S-PRG) filler. The four experimental groups and the control group were compared using the Kruskal-Wallis test, followed by the Steel-Dwass post-hoc test to compare the histopathological score. The Mann-Whitney U test was used to compare the histopathological score at 14 and 28 days for each observation item. All experimental adhesives containing S-PRG fillers developed for direct pulp capping showed no pulpal inflammation. After 14 days, the experimental adhesives containing S-PRG fillers and the control group formed tertiary dentin around the exposed pulp. After 28 days, the experimental adhesives containing 13 and 27 wt% of S-PRG fillers formed dentin bridge equal to the control.

show abstract

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of an experimental adhesive resin containing multi-ion releasing fillers on direct pulp-capping

2016

View full text Add to dashboard Cite

show abstract

“…811) Sr 2+ doping was also expected to have the similar effect of decreased osteoclast activity and increased osteoblasts activity. 3) In addition to the biological effect of doped metal ions, it is also likely that the doped ions significantly affect crystallization and growth of HAp crystals in vivo and in vitro. Fuierer 14) It is considered that protein adsorption as well as HAp growth is an important step for bone formation.…”

Section: Introductionmentioning

confidence: 99%

Theoretical Calculations of Segregation Behavior of Zinc and Magnesium at Hydroxyapatite Surface in Contact with Water

et al. 2013

View full text Add to dashboard Cite

“…Lower doses of F, on the other hand, can be used to increase bone mass in a regular fashion without any noticeable formation of mineralization defects 19,21) . The effects of F on bone cells in monolayer culture are well known: fluoride has a dose-dependent effect on cell proliferation, extracellular matrix production, and alkaline phosphate activity 1,3) .…”

Section: Introductionmentioning

confidence: 99%

Effect of Magnesium, Strontium or Fluoride Ions on in vitro Activities of Odontoblast-like Cells (MDPC-23)

Inoue

LeGeros

Inoue

et al. 2005

J. Hard Tissue Biology.

View full text Add to dashboard Cite

Magnesium (Mg), strontium (Sr) or fluoride (F) ions have been shown to affect in vitro activities of bone cells and in vivo mineralization. The purpose of this study was to investigate the effect of Mg, Sr and F ions on the activities of odontoblast-like cells (MDPC-23) using an in vitro cell culture model. Mg, Sr or F ions were added to the medium in the following concentrations: Mg -1, 5, 10 mM; Sr -0.05, 0.1, 0.3, 1 mM; F-0.005, 0.01, 0.05, 0.1 mM. Results were observed after 1, 7 and 14 days using Von Kossa staining, scanning and transmission electron microscopy. Preliminary results showed the following: Mg ions demonstrated a positive effect at low concentrations and a negative effect at high concentrations; Sr ions demonstrated a positive dose dependent effect up to a concentration of 0.1 mM and a negative effect at higher concentrations; and F ions demonstrated a positive dose-dependent effect up to a concentration of 0.005 mM and inhibitory effects at higher concentrations. This preliminary study showed that the positive or negative effects of Mg, Sr or F ions on odontoblastic activities (proliferation and mineralization) depend on their concentration levels in the environment.

show abstract

Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect

Cited by 198 publications

References 22 publications

Effect of an experimental adhesive resin containing multi-ion releasing fillers on direct pulp-capping

Effect of an experimental adhesive resin containing multi-ion releasing fillers on direct pulp-capping

Theoretical Calculations of Segregation Behavior of Zinc and Magnesium at Hydroxyapatite Surface in Contact with Water

Effect of Magnesium, Strontium or Fluoride Ions on in vitro Activities of Odontoblast-like Cells (MDPC-23)

Contact Info

Product

Resources

About