Strontium‐incorporated titanium implant surface treated by hydrothermal reactions promotes early bone osseointegration in osteoporotic rabbits

Abstract

Objectives The aim of the present study was to investigate the effects of strontium‐modified implant surfaces on promoting early bone osseointegration in osteoporotic rabbits. Materials and methods The surface topographies, chemical elements, contact angles and ionic releases of the SLA and SLA‐Sr samples were analysed by special instruments separately. Sixteen ovariectomized New Zealand rabbits received glucocorticoid administration, and sixteen SHAM rabbits were used as controls. After generating a successful osteoporosis‐induced model, SLA and SLA‐Sr implants were randomly inserted into the tibia and femur metaphysis of each animal. The rabbits were sacrificed after 3 and 6 weeks of bone healing, and then, removal torque values (RTVs), percentage of bone area (BA%) and percentage of bone‐to‐implant contact (BIC%) were analysed for the SLA‐Sr and SLA implants. Results Multiple nanostructures were found on the Sr‐incorporated titanium surface, and appropriate amounts of strontium ions from the SLA‐Sr surface were released into the surrounding tissue within 21 days. In vivo, SLA‐Sr implants displayed much more new bone around their surfaces than the SLA implants. Significantly higher RTVs and BIC% were observed for the SLA‐Sr implants than for the SLA implants in both osteoporotic (p < 0.01) and healthy animals (p < 0.01) at 3 and 6 weeks. The SLA‐Sr implants exhibited higher BA% in cortical bone (p < 0.01) and in cancellous bone (p < 0.05) than the SLA implants in osteoporotic rabbits at 3 weeks. Conclusions It is suggested that Sr‐incorporated surfaces treated through hydrothermal reactions have positive effects on promoting early osseointegration in both osteoporotic and non‐osteoporotic rabbits.

Osteoimmunomodulatory Effects of Enamel Matrix Derivate and Strontium Coating Layers: A Short- and Long-Term In Vivo Study

“… 57 The observed short-term bone healing effects of strontium were also in agreement with the Lin et al 50 study, which demonstrated that strontium-modified surfaces induce early osseointegration in rabbits. 50 …”

Strontium‐incorporated titanium implant surfaces treated by hydrothermal treatment enhance rapid osseointegration in diabetes: A preclinical vivo experimental study

“…in the previous animal experiment in rabbits (Lin et al, 2019). At 8 weeks after implantation, SLA-Sr implant surfaces also displayed better osseointegration in diabetic rats, but there was no difference between two surfaces in the normal group.…”

Impact of exogenous metal ions on peri-implant bone metabolism: a review

“…Hydrothermal treatment 18,19 Chemical reactions that take place in a liquid phase at high temperature Simple; economical, effective; environmentally friendly; uniform thickness of the deposited layer Some substances are heat-sensitive PIII 20,21 A material engineering process by which ions are accelerated in an electrical eld and impacted onto the surface of a substrate to change the surface chemistry Suitable for processing implants with complex shapes Technical complexity; high costs; high dissolution rate Micro-arc oxidation 22,23 Arc discharge is used to enhance and activate the reaction on the anode, which produces a thick and relatively stable oxide lm on the surface of the metal and its alloy Multi-microporous structure can achieve long-term stable release of metal ions; corrosion-resistant…”

“…17 The performances of different surface modication techniques used for the incorporation of metallic ions are summarized in Table 2. [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] In this paper, we review the adverse effects of metal ions on osseointegration and highlight the emerging applications for metal elements in improving the performance of dental implants.…”