Strontium combined with bioceramics for osteoporotic bone repair: Oral intake or as a dopant?

Chen, Siyu; Zhao, Rui; Xing, Zhengyi; Shang, Tieliang; Yang, Xiao; Zhu, Xiangdong; Zhang, Xingdong

doi:10.1016/j.apmt.2020.100927

Cited by 17 publications

(18 citation statements)

References 51 publications

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“…Compared to wHA, a significantly higher b H value observed in the nwHA2 group was in accordance with a higher calcium/phosphate ratio characterized by SEM/EDS analysis, indicating a more mature bone matrix with higher mineral content [ 32 , 56 ]. Aligned with our previous findings, the retrieved bioceramic implants with poor osteointegration ability, such as wHA here, possessed an abnormally higher m E and m H than the host bone due to the undegraded material brittleness and phase composition [ 31 , 57 ]. However, bioceramic implants that could integrate well with host bone, such as nwHA2, often presented a force-indentation depth curve similar to that of newly formed bone, revealing a higher degree of ossification and homogenization [ 22 ].…”

Section: Discussionsupporting

confidence: 88%

Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles

Zhao

Shang

Yuan

et al. 2022

Bioactive Materials

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Section: Discussionsupporting

confidence: 88%

Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles

Zhao

Shang

Yuan

et al. 2022

Bioactive Materials

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“…Treatment of cells directly with BcHA allowed greater cell junctions to be formed and induced a higher number of cells to form lamellopodia. As reported elsewhere, cells may migrate and proliferate in interconnected clusters as a result of supportive mechanobiological influence of surface topography, bioactive ions, or coculture systems. , Here, BcHA-treated hFOBs were found to exhibit similar spatial control over morphology of cells in terms of forming less spindle-like but more round and spread morphology compared to cells on cHA or Ctrl (Figure D–G). Hence, it can be said that the abovementioned findings corroborated the positive influence of BcHA on both direct and indirect contact with human osteoblasts.…”

Section: Discussionsupporting

confidence: 77%

Versatile-in-All-Trades: Multifunctional Boron-Doped Calcium-Deficient Hydroxyapatite Directs Immunomodulation and Regeneration

Pazarçeviren

Akbaba

Evis

et al. 2022

ACS Biomater. Sci. Eng.

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Osseointegration of implants depends on several intertwined factors: osteogenesis, angiogenesis, and immunomodulation. Lately, novel reinforcements allowing faster bonding with osseous tissue have been explored intensively. In this study, we hypothesized the use of boron as a major multifunctional ion to confer versatility to calcium-deficient hydroxyapatite (cHA) synthesized by a wet precipitation/microwave reflux method. By synthesis of boron-doped calcium-deficient hydroxyapatite (BcHA), we expected to obtain an osteoimmunomodulatory and regenerative nanoreinforcement. BcHA was found to possess a pure HA phase, a greater surface area (66.41 m 2 /g, p = 0.028), and cumulative concentrations of Ca (207.87 ± 6.90 mg/mL, p < 0.001) and B (112.70 ± 11.79 mg/mL, p < 0.001) released in comparison to cHA. Osteogenic potential of BcHA was analyzed using human fetal osteoblasts. BcHA resulted in a drastic increase in the ALP activity (1.11 ± 0.11 mmol/gDNA·min, p < 0.001), biomineralization rate, and osteogenic gene expressions compared to cHA. BcHA angiogenic potential was investigated using human umbilical cord vein endothelial cells. Significantly, the highest VEGF-A release (1111.14 ± 87.82 in 4 h, p = 0.009) and angiogenic gene expressions were obtained for BcHA-treated samples. These samples were also observed to induce a more prominent and highly branched tube network. Finally, inflammatory and inflammasome responses toward BcHA were elucidated using human monocyte-derived macrophages differentiated from THP-1s. BcHA exhibited lower CAS-1 release (50.18 ± 5.52 μg/g DNA μg/gDNA) and higher IL-10 release (126.97 ± 15.05 μg/g DNA ) than cHA. In addition, BcHA treatment led to increased expression of regenerative genes such as VEGF-A, RANKL, and BMP-2. In vitro results demonstrated that BcHA has tremendous osteogenic, angiogenic, and immunomodulatory potential to be employed as a “versatile-in-all-trades” modality in various bone tissue engineering applications.

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“…Chen et al described the effectiveness of taking SrRan orally with the implantation of materials modified with Sr ions [ 72 ]. The study proved that such a combination has a great influence on the improvement of osseointegration ability and positively influences the angiogenesis process.…”

Section: Strontium In the Treatment Of Osteoporosismentioning

confidence: 99%

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

Kołodziejska

Stępień

Kolmas

2021

IJMS

151

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Osteoporosis is a chronic disease characterized by low bone mass caused by increased bone turnover and impaired bone microarchitecture. In treatment, we use antiresorptive or anabolic drugs, which usually have a unidirectional effect, i.e., they inhibit the activity of osteoclasts or stimulate the effect of osteoblasts. Strontium ranelate is an anti-osteoporosis drug with a unique mechanism of action (used primarily in postmenopausal women). Unlike other medicines, it has a multidirectional effect on bone tissue, intensifying osteoblastogenesis while inhibiting osteoclastogenesis. It turns out that this effect is demonstrated by strontium ions, an element showing physical and chemical similarity to calcium, the basic element that builds the mineral fraction of bone. As a result, strontium acts through the calcium-sensing receptor (CaSR) receptor in bone tissue cells. In recent years, there has been a significant increase in interest in the introduction of strontium ions in place of calcium ions in ceramics used as bone replacement materials for the treatment of bone fractures and defects caused by osteoporosis. The aim of this study was to summarize current knowledge about the role of strontium in the treatment of osteoporosis, its effects (in various forms), and the ways in which it is administered.

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Strontium combined with bioceramics for osteoporotic bone repair: Oral intake or as a dopant?

Cited by 17 publications

References 51 publications

Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles

Osteoporotic bone recovery by a bamboo-structured bioceramic with controlled release of hydroxyapatite nanoparticles

Versatile-in-All-Trades: Multifunctional Boron-Doped Calcium-Deficient Hydroxyapatite Directs Immunomodulation and Regeneration

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment

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