Strontium, cerium co-substituted hydroxyapatite nanoparticles: Synthesis, characterization, antibacterial activity towards prokaryotic strains and in vitro studies

Gopi, D.; Ramya, S.; Rajeswari, D.; Kumaravel, P.; Kavitha, L.

doi:10.1016/j.colsurfa.2014.03.035

Cited by 117 publications

(90 citation statements)

References 51 publications

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“…The produced systems include the co-substitution of zinc/silver [209], silver/strontium [211], carbonate/strontium [492], carbonate/magnesium [454,493], carbonate/sodium [494], carbonate/silicate [495], yttrium/silicon [496], zinc/silicate [497], zinc/copper [498], strontium/cerium [499], magnesium/ strontium [500], magnesium/silver [501], and carbonate/silicate/magnesium [454]. However, the co-substitution of multiple (more than two) ions has not deeply and systematically attempted and investigated, and thus, it can be considered as a promising research field to be still and further explored and expanded [502,480].…”

Section: Discussionmentioning

confidence: 99%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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Section: Discussionmentioning

confidence: 99%

Cationic and Anionic Substitutions in Hydroxyapatite

Cacciotti¹

2016

Handbook of Bioceramics and Biocomposites

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“…However, the successful application of HAP has several disadvantages which also involve the lack of antibacterial activity that impacts its long-term stability and gives rise to implant failures [6]. This induces the increased risk of bacterial adherence and colonization of the metallic implants coated with HAP [7].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

et al. 2014

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This work elucidated the antibacterial efficacy, corrosion resistance, and cytotoxicity of electroplated copper-substituted hydroxyapatite (CuHAP) coating on titanium (Ti). The fabricated CuHAP coatings were characterized by scanning electron microscopy, energydispersive X-ray analysis spectroscopy, Fourier transform infrared spectroscopy, and X-ray diffraction studies. The CuHAP coating had needle-like apatite crystals, the doping of Cu 2? into HAP reduced porosity, and the coating became denser. The CuHAP crystals were carbonated with a few of Cu 2? incorporation (about 0.80 wt%). The Cu 2? ions were homogenously deposited into HAP films. Potentiodynamic polarisation test revealed that the CuHAP coating provided good barrier characteristics and achieved superior corrosion protection for Ti substrates. The in vitro antibacterial activity of asprepared CuHAP coating was evaluated against Escherichia coli and was found to be effectively high against bacterial colonization. Bioactivity test conducted by soaking the coatings in simulated body fluid demonstrated that CuHAP coating can quickly induce bone-like apatite nucleation and growth. In vitro biocompatibility tests, MTT, were employed to assess the cytotoxicity of Cu-HAP coating with osteoblast-like MC3T3-E1 cells. The obtained HAP coating doped with a low content of Cu 2? exhibited good cytocompatibility and had no toxicity toward MC3T3-E1.

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“…Various metal ions, such as: Ag + , Cu 2+ , Zn 2+ , Ce 3+ , Eu 3+ , Sr 2+ , Ga 3+ , Ti 4+ and Co 2+ ; have been used to doped hydroxyapatite biomaterials with in order to get antibacterial activity [11][12][13][23][24][25]. In vitro studies have showed that silver doped hydroxyapatite materials have no significant cytotoxic activity [13,26,27].…”

Section: Introductionmentioning

confidence: 99%