Strongly enhanced IL-10 production using stable galectin-1 homodimers

The AP1-dependent secretion of galectin-1 by Reed–Sternberg cells fosters immune privilege in classical Hodgkin lymphoma

“…In these studies, the administration of Gal1 dramatically suppressed Th1-dependent responses and skewed toward Th2 cytokine profiles (17)(18)(19)(20)29). A careful examination of the mechanisms involved in Gal1-mediated Th2 skewing recently revealed that Th1 cells express the repertoire of cell surface glycans required for Gal1 binding and subsequent cell death, whereas Th2 cells are protected from Gal1 by differential sialylation of their cell surface glycoproteins (30).…”

Functions of cell surface galectin-glycoprotein lattices

“…Compelling evidence indicates that galectin-1 treatment suppresses chronic inflammation, modulates T-cell survival and skews the balance towards a Th2 cytokine profile in vitro [42] and in vivo in animal models, including experimental autoimmune uveitis [43] and autoimmune diabetes [44]. Furthermore, selective blockade of galectin-1 in tumor tissue results in increased Th1-mediated anti-tumor responses, suggesting potential involvement of this protein in tumorimmune escape [45].…”

Roles of galectins in inflammatory bowel disease

“…Administration of human recombinant galectin-1 contributes to the reduction of Th1 cytokine (TNF-α, IL-1β, IL-12 and IFN-γ) release and the suppression of this intestinal inflammation by specifically inducing the apoptosis of effector T cells responsible for production of IFN-γ [17] . In addition, a recent study has demonstrated that administration of recombinant galectin-1 also contributes to increase IL-10 production in CD4+ and CD8+ T cells [46] . These data clearly address the therapeutic potential of galectin-1 to skew the balance from a Th1-toward a Th2-polarized immune response that induces a remission state in the evolution of the ongoing inflammatory disorders.…”